scholarly journals Tumor Heterogenity in Gastro-Entero-Pancreatic Neuroendocrine Neoplasia

Endocrines ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 28-36
Author(s):  
Ludovica Magi ◽  
Maria Rinzivillo ◽  
Francesco Panzuto

Owing to the rarity and the biological and clinical heterogeneity of gastroenteropancreatic neuroendocrine neoplasia (GEP NEN), the management of these patients may be challenging for physicians. This review highlights the specific features of GEP NEN with particular attention on the role of Ki67 heterogeneity, the potential prognostic role of novel radiological techniques, and the clinical usefulness of functional imaging, including 68Ga-DOTA-SST PET/CT and 18F-FDG PET/CT. Understanding these specific features may help to plan proper and tailored follow-up programs and therapeutic approaches.

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 519.2-519
Author(s):  
G. Pazzola ◽  
M. Casali ◽  
F. Muratore ◽  
N. Pipitone ◽  
L. Boiardi ◽  
...  

2018 ◽  
Vol 32 (8) ◽  
pp. 532-541 ◽  
Author(s):  
Domenico Albano ◽  
Mattia Bertoli ◽  
Marco Battistotti ◽  
Carlo Rodella ◽  
Massimo Statuto ◽  
...  

2017 ◽  
Vol 59 (9) ◽  
pp. 1082-1090 ◽  
Author(s):  
Dongyong Zhu ◽  
Yanfang Wang ◽  
Lisha Wang ◽  
Jie Chen ◽  
Sama Byanju ◽  
...  

Background 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) has been widely used in clinical practice. However, the prognostic value of the pre-treatment standardized uptake value (SUV) for patients with small-cell lung cancer (SCLC) remains controversial. Purpose To investigate the prognostic role of pre-treatment 18F-FDG PET on SCLC patients by meta-analysis. Material and Methods Extensive literature searches of the PubMed, EMBASE, Web of Science, and Cochrane Library databases were conducted to identify literature published until 5 May 2017. Comparative analyses of the pooled hazard ratios (HRs) for event-free survival (EFS) and overall survival (OS) were performed to assess their correlations with the pre-treatment maximum SUV (SUVmax). Either the fixed- or the random-effects model was adopted, depending on the heterogeneity observed across the studies. Subgroup analyses were performed to assess the robustness of the results. Results Twelve studies with 1062 patients were included. The pooled HR for OS of 11 studies was 1.13 (95% confidence interval [CI] = 1.05–1.22; P = 0.001; I2 = 0%) and the pooled HR for EFS of nine studies was 1.09 (95% CI = 1.02–1.17; P = 0.014; I2 = 0%), indicating that patients with high SUVs may have poorer prognoses. Begg’s test detected no significant publication bias. The prognostic role of the SUVmax remained similar in the subgroup analyses. Conclusion Our meta-analysis indicated that the pre-treatment SUVmax of primary lesions can be an important prognostic factor for OS and EFS in patients with SCLC. A high SUVmax may indicate poorer prognosis.


2020 ◽  
Vol 28 (2) ◽  
pp. 119
Author(s):  
Renata Milardovic ◽  
Nermina Beslic ◽  
Amera Sadija ◽  
Sejla Ceric ◽  
Melika Bukvic ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Pet Ct ◽  
18F Fdg ◽  

2016 ◽  
Vol 41 (7) ◽  
pp. e313-e322 ◽  
Author(s):  
Ana María García Vicente ◽  
Mariano Amo-Salas ◽  
Fernanda Relea Calatayud ◽  
María del Mar Muñoz Sánchez ◽  
Francisco José Pena Pardo ◽  
...  

2011 ◽  
Vol 9 (1) ◽  
pp. 75 ◽  
Author(s):  
Elgin Ozkan ◽  
Mine Araz ◽  
Cigdem Soydal ◽  
Ozlem N Kucuk

2018 ◽  
Vol 46 (1) ◽  
pp. 87-96 ◽  
Author(s):  
Domenico Albano ◽  
Giovanni Bosio ◽  
Chiara Pagani ◽  
Alessandro Re ◽  
Alessandra Tucci ◽  
...  

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