Quality of Life in Adults with Metabolic Dysfunction-Associated Fatty Liver Disease

The aims of this study were as follows: to investigate the association between metabolic dysfunction-associated fatty liver disease (MAFLD) and health-related quality of life (HRQoL), to evaluate whether stress perception and mental health among patients with MAFLD affect HRQoL, and to identify the underrated burden on MAFLD patients. Nationwide data from the 5th Korean National Health and Nutrition Examination Survey (KNHANES V, 2010 to 2012) were used. MAFLD was defined by a fatty liver index (FLI) of ≥60, and the EuroQol-5D (EQ-5D) was used to assess HRQoL. Logistic regression analysis and odds ratios (ORs) were used to determine the associations of MAFLD with stress, mental health, and HRQoL. Previous suicidal impulse was not found to be significantly associated with HRQoL. The risk of MAFLD increased 1.265-fold with an increase in stress levels based on the stress perception rate (confidence index (CI): 1.046–1.530; p < 0.05), while it increased 1.091-fold with a 1-point decrease in the EQ-5D score (CI: 1.019–1.169; p < 0.05). HRQoL impairment and stress levels are associated with MAFLD. It is important to evaluate stress levels among MAFLD patients and implement stress management and HRQoL improvement strategies.

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Mo1546 Health-Related Quality of Life and Health Utilities in Patients With Non-Alcoholic Fatty Liver Disease

Gastroenterology ◽

10.1016/s0016-5085(16)33850-1 ◽

2016 ◽

Vol 150 (4) ◽

pp. S1141

Author(s):

Mehmet Sayiner ◽

Maria Stepanova ◽

Huong Pham ◽

Bashir Noor ◽

Mercedes Walters ◽

...

Keyword(s):

Quality Of Life ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Health Related Quality ◽

Alcoholic Fatty Liver ◽

Related Quality ◽

Health Related ◽

Alcoholic Fatty Liver Disease

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Quality of life of patients with non-alcoholic fatty liver disease with different thyroid status

Medical alphabet ◽

10.33667/2078-5631-2021-35-57-61 ◽

2021 ◽

pp. 57-61

Author(s):

E. V. Chernyadeva ◽

A. E. Shklyaev

Keyword(s):

Quality Of Life ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Primary Hypothyroidism ◽

Alcoholic Fatty Liver ◽

Personal Anxiety ◽

Alcoholic Fatty Liver Disease ◽

Ethylmethylhydroxypyridine Succinate

The aim. To study the quality of life and psychoemotional state of patients with non-alcoholic fatty liver disease against the background of primary hypothyroidism during the use of ethylmethylhydroxypyridine succinate.Materials and methods. 111 patients with non-alcoholic fatty liver were examined, among them 35 were without thyroid dysfunction, 55 with compensated primary hypothyroidism, 21 with decompensated hypothyroidism. The patients underwent general clinical, biochemical, enzyme-linked immunosorbent assays of blood, instrumental studies, testing according to psychological questionnaires.Results. With decompensation of hypothyroidism, a statistically significant increase in indicators of depression, situational and personal anxiety was revealed in comparison with patients without hypothyroidism. The examined patients showed an increase in the level of situational and personal anxiety. The presence of hypothyroidism in the examined patients significantly worsens these indicators, leading to an increase in the degree of anxiety, aggravated by decompensation of hypothyroidism. A positive dynamic was revealed in the correction of the psychoemotional status of patients in the observation group during the complex treatment with ethylmethylhydroxypyridine succinate: the severity of depression, situational and personal anxiety, manifestations of dyspeptic and reflux syndromes decreased.Conclusion. Hypothyroidism affects the quality of life and psycho-emotional state of patients with non-alcoholic fatty liver disease: it worsens the degree of depression, situational and personal anxiety. The addition of ethylmethylhydroxypyridine succinate to standard therapy with sodium levothyroxine in patients with non-alcoholic fatty liver disease in the setting of hypothyroidism improves the quality of life and psycho-emotional state.

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