Effect of Physical Therapy Modalities on Quality of Life of Head and Neck Cancer Survivors: A Systematic Review with Meta-Analysis

The objective was to describe the effectiveness of different physical therapy modalities to improve Quality of Life (QoL) in Head and Neck Cancer (HNC) survivors. PubMed, Scopus, Web of Science, CINAHL and Cochrane Library were searched for randomized clinical controlled trials published until 30 April 2020. Risk of bias assessment and meta-analysis were conducted using the Cochrane tools. A total of 251 records were retrieved, and 10 met the inclusion criteria. Interventions whose parameters focus on a 12-week exercise programs of aerobic activity (walking) or Progressive Resistance Training (PRT) for the whole body are effective and safe modalities improving QoL in HNC survivors. Electrophysical agents did not show significant results between groups. As for the assessment of methodological quality, 4 of the 10 articles included had a high risk of overall bias. Only five articles provided sufficient information to conduct a meta-analysis for exercise program intervention on QoL, showing a tendency in favor of intervention group, even when the global results did not show statistically significant improvements (pooled Cohen’s d 0.15; 95% CI: −0.25 to 0.54; I2 45.87%; p heterogeneity = 0.10). The present review and meta-analysis identified meaningful benefits of exercise on QoL of HNC survivors; this has been confirmed in a meta-analysis. This review adds evidence supporting exercise interventions on Head and Neck Cancer population whose opportunities for successful recovery after medical treatment are more limited.

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The effect of psychological interventions on quality of life in patients with head and neck cancer: A systematic review and meta-analysis

European Journal of Cancer Care ◽

10.1111/ecc.12789 ◽

2017 ◽

Vol 27 (1) ◽

pp. e12789 ◽

Cited By ~ 6

Author(s):

L. Calver ◽

A. Tickle ◽

N. Moghaddam ◽

S. Biswas

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Meta Analysis ◽

Psychological Interventions

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Effects of a Physical Therapy Program on Quality of Life, and Neck and Shoulder Disability in Patients With Head and Neck Cancer

Physical Therapy Korea ◽

10.12674/ptk.2013.20.1.036 ◽

2013 ◽

Vol 20 (1) ◽

pp. 36-46 ◽

Cited By ~ 1

Author(s):

Jung-Hwa Do ◽

You-Hoi Jung ◽

Eun-Ji Song ◽

Soon-Yong Jung ◽

Young-Ki Cho

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Physical Therapy ◽

Head And Neck ◽

Neck Cancer ◽

Therapy Program ◽

Physical Therapy Program ◽

Shoulder Disability

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Neuromuscular function and fatigability in people diagnosed with head and neck cancer before versus after treatment

10.31236/osf.io/6y4m5 ◽

2019 ◽

Author(s):

Colin Lavigne ◽

Harold Lau ◽

George Francis ◽

S. Nicole Culos-Reed ◽

Guillaume Y. Millet ◽

...

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Whole Body ◽

Health Related Quality ◽

Patient Reported ◽

Related Quality ◽

Health Related

Purpose: Treatment for head and neck cancer is associated with multiple side-effects, including loss of body mass, impaired physical function, and reduced health-related quality of life. This study aimed to investigate the impact of treatment (radiation therapy ± concurrent chemotherapy) on (i) muscle strength, muscle cross-sectional area and patient-reported outcomes, and (ii) central and peripheral alterations during a whole-body exercise task.Methods: Ten people with head and neck cancer (4 female; 50±9 years) completed a lab visit before and after (56±30 days) completion of treatment. Participants performed a neuromuscular assessment (involving maximal isometric voluntary contractions in the knee extensors and electrical stimulation of the femoral nerve) before and during intermittent cycling to volitional exhaustion. Anthropometrics and patient-reported outcomes were also assessed.Results: From before to after treatment, maximal isometric muscle strength was reduced (P=0.002, d=0.73), as was potentiated twitch force (P<0.001, d=0.62), and muscle cross-sectional area (e.g. vastus lateralis: P=0.010, d=0.64). Exercise time was reduced (P = 0.008, d = 0.62) and peripheral processes contributed to a reduction in maximal force due to cycling. After treatment, the severity of self-reported fatigue increased (P=0.041, r=-0.65) and health-related quality of life decreased (P=0.012, r=-0.79).Conclusion: Neuromuscular function was impaired in patients with head and neck cancer after treatment. Whole-body exercise tolerance was reduced and resulted in predominantly peripheral, rather than central, disturbances to the neuromuscular system. Future research should evaluate strength training after treatment for head and neck cancer, with the overall aim of reducing fatigue and improving health-related quality of life.

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Identity processing styles and quality of life in head and neck cancer.

Canadian Journal of Behavioural Science/Revue canadienne des sciences du comportement ◽

10.1037/cbs0000241 ◽

2020 ◽

Author(s):

Kaleem Khan ◽

Guy Pelletier

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Processing Styles ◽

Identity Processing

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Faculty Opinions recommendation of Late complications and long-term quality of life for survivors (>5 years) with history of head and neck cancer.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717952796.793457670 ◽

2012 ◽

Author(s):

Giulio Cantu ◽

Madia Pompilio ◽

Paolo Formillo

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Late Complications ◽

History Of

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Salivary DNA Methylation as an Epigenetic Biomarker for Head and Neck Cancer. Part I: A Diagnostic Accuracy Meta-Analysis

Journal of Personalized Medicine ◽

10.3390/jpm11060568 ◽

2021 ◽

Vol 11 (6) ◽

pp. 568

Author(s):

Óscar Rapado-González ◽

Cristina Martínez-Reglero ◽

Ángel Salgado-Barreira ◽

Laura Muinelo-Romay ◽

Juan Muinelo-Lorenzo ◽

...

Keyword(s):

Dna Methylation ◽

Head And Neck Cancer ◽

Diagnostic Accuracy ◽

Head And Neck ◽

Likelihood Ratio ◽

Neck Cancer ◽

Meta Analysis ◽

Positive Likelihood Ratio ◽

Epigenetic Mechanism ◽

Cochrane Library

DNA hypermethylation is an important epigenetic mechanism for gene expression inactivation in head and neck cancer (HNC). Saliva has emerged as a novel liquid biopsy representing a potential source of biomarkers. We performed a comprehensive meta-analysis to evaluate the overall diagnostic accuracy of salivary DNA methylation for detecting HNC. PubMed EMBASE, Web of Science, LILACS, and the Cochrane Library were searched. Study quality was assessed by the Quality Assessment for Studies of Diagnostic Accuracy-2, and sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (dOR), and their corresponding 95% confidence intervals (CIs) were calculated using a bivariate random-effect meta-analysis model. Meta-regression and subgroup analyses were performed to assess heterogeneity. Eighty-four study units from 18 articles with 8368 subjects were included. The pooled sensitivity and specificity of salivary DNA methylation were 0.39 and 0.87, respectively, while PLR and NLR were 3.68 and 0.63, respectively. The overall area under the curve (AUC) was 0.81 and the dOR was 8.34. The combination of methylated genes showed higher diagnostic accuracy (AUC, 0.92 and dOR, 36.97) than individual gene analysis (AUC, 0.77 and dOR, 6.02). These findings provide evidence regarding the potential clinical application of salivary DNA methylation for HNC diagnosis.

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