scholarly journals Phorbaketal A, Isolated from the Marine Sponge Phorbas sp., Exerts Its Anti-Inflammatory Effects via NF-κB Inhibition and Heme Oxygenase-1 Activation in Lipopolysaccharide-Stimulated Macrophages

Marine Drugs ◽  
2015 ◽  
Vol 13 (11) ◽  
pp. 7005-7019 ◽  
Author(s):  
Yun-Ji Seo ◽  
Kyung-Tae Lee ◽  
Jung-Rae Rho ◽  
Jung-Hye Choi
2006 ◽  
Vol 106 (3) ◽  
pp. 364-371 ◽  
Author(s):  
Byung-Chul Kim ◽  
Joung-Woo Choi ◽  
Hye-Young Hong ◽  
Sin-Ae Lee ◽  
Suntaek Hong ◽  
...  

2004 ◽  
Vol 142 (7) ◽  
pp. 1191-1199 ◽  
Author(s):  
María José Alcaraz ◽  
Ana María Vicente ◽  
Amparo Araico ◽  
José N Dominguez ◽  
María Carmen Terencio ◽  
...  

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Jinming Peng ◽  
Tianyong Hu ◽  
Jin Li ◽  
Jing Du ◽  
Kerui Zhu ◽  
...  

Shepherd’s purse (Capsella bursa-pastoris (L.) Medik.), a wild herb as a traditional herbal medicine, has been proved with multiple healthy benefits. In this study, the chemical constituents of shepherd’s purse were identified by UPLC-QTOF-MS/MS. The antioxidative and anti-inflammatory potential of shepherd’s purse extract (SPE) were also investigated applying lipopolysaccharide- (LPS-) induced inflammation in RAW 264.7 macrophages and a carrageenan-induced mice paw edema model. Twenty-four chemical compounds were identified mainly including phenolic acids and flavonoids. The data also indicated SPE inhibited the productions of NO, PGE2, TNF-α, and IL-6 stimulated with LPS. In addition, SPE inhibited the increase of reactive oxygen species (ROS) and upregulated the expression of heme oxygenase-1 (HO-1). We further found that SPE inhibited the phosphorylation of P38 MAPK and activation of NF-κB. In vivo mice model also indicated that SPE showed strong antioxidative and anti-inflammatory activity.


2009 ◽  
Vol 58 (5) ◽  
pp. 257-262 ◽  
Author(s):  
S. H. Lee ◽  
J. Y. Kim ◽  
G. S. Seo ◽  
Y.-C. Kim ◽  
D. H. Sohn

2015 ◽  
Vol 241 (4) ◽  
pp. 396-408 ◽  
Author(s):  
Xue Meng ◽  
Inhye Kim ◽  
Yong Joon Jeong ◽  
Young Mi Cho ◽  
Se Chan Kang

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