Background:
Inflammation involves a dynamic network that is highly regulated by signals that initiate the inflammation process as well as signals that downregulate it. However, an imbalance between the two leads to tissue damage.
Throughout the world, inflammatory disease becomes common in the aging society. The drugs which are used clinically
suffer serious side effects. Natural products or compounds derived from natural products show diversity in structure and
play an important role in drug discovery and development.
Objective:
Oreganum Vulgare is used in traditional medicine for various ailments including respiratory and rheumatic disorders, severe cold, suppression of tumors. The current study aims to evaluate the anti-inflammatory potential by evaluating
various in-vitro parameters.
Results:
The extracts (OVEE, OVEAF) as well as the isolated compound(OVRA)of Oreganum Vulgare inhibit the proinflammatory cytokines (IL-6 and TNF-α) and NO without affecting cell viability.
Conclusion:
Our study established that the leaf extracts of Oreganum Vulgare exhibits anti-inflammatory activity and thus
confirm its importance in traditional medicine.
Anti-Inflammatory Activity of Natural Products
