Copper-Catalyzed Synthesis of Axially Chiral Biaryls with Diaryliodonium Salts as Arylation Reagents
Keyword(s):
NOBIN and BINAM derivatives harboring biaryl frameworks are recognized as a class of important atropisomers with versatile applications. Here, we present an efficient synthetic route to access such compounds through copper-catalyzed domino arylation of N-arylhydroxylamines or N-arylhydrazines with diaryliodonium salts and [3,3]-sigmatropic rearrangement. This reaction features mild conditions, good substrate compatibility, and excellent efficiency. The practicality of this protocol was further extended by the synthesis of biaryl amino alcohols.
2004 ◽
Vol 77
(6)
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pp. 1217-1227
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2012 ◽
Vol 10
(15)
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pp. 3071
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2010 ◽
Vol 75
(20)
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pp. 7010-7013
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2003 ◽
Vol 68
(16)
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pp. 6329-6337
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