This paper analyzes the logistics distribution system, logistics and distribution of agricultural products and agricultural products logistics enterprise status,Demand for agricultural products logistics companies point clustering analysis, Determine the economic and non-economic rational and reasonable point point,To TSP problem-based, Application of improved genetic algorithm to determine its distribution route, Use natural number coding chromosome structure represents feasible route, greedy crossover, mutation and reverse the 2-opt other methods, With VC + + and MATLAB programming of the algorithm, And empirical analysis proves the validity of the algorithm.