Faculty Opinions recommendation of Suppression of cathepsin B expression in Schistosoma mansoni by RNA interference.

2003 ◽  
Author(s):  
Michael Cappello
Keyword(s):  
Rna Interference ◽  
Schistosoma Mansoni ◽  
Cathepsin B

Suppression of cathepsin B expression in Schistosoma mansoni by RNA interference

2003 ◽  
Vol 33 (4) ◽  
pp. 363-369 ◽  
Author(s):  
Patrick J Skelly ◽  
Akram Da'dara ◽  
Donald A Harn
Keyword(s):  
Rna Interference ◽  
Schistosoma Mansoni ◽  
Cathepsin B

Immunogenicity of synthetic peptides from the Sm31 antigen (cathepsin B) of the Schistosoma mansoni adult worms

2001 ◽  
Vol 23 (11) ◽  
pp. 567-573 ◽  
Author(s):  
Oscar Noya ◽  
Belkisyolé Alarcón De Noya ◽  
Diana E. Ballen ◽  
Henry Bermúdez ◽  
Daniel Bout ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Cathepsin B ◽  
Synthetic Peptides

The cysteine proteinases of Schistosoma mansoni cercariae

Parasitology ◽  
1997 ◽  
Vol 114 (2) ◽  
pp. 105-112 ◽  
Author(s):  
J. P. DALTON ◽  
K. A. CLOUGH ◽  
M. K. JONES ◽  
P. J. BRINDLEY
Keyword(s):  
Schistosoma Mansoni ◽  
Cathepsin B ◽  
Cathepsin L ◽  
Serine Proteinase ◽  
Skin Penetration ◽  
Scanning Electron Micrographs ◽  
Cysteine Proteinases ◽  
Similar Function ◽  
Substrate Preferences ◽  
Serine Proteinase Activity

Based on substrate preferences, cercariae of Schistosoma mansoni were seen to express both cathepsin L and cathepsin B cysteine proteinases, although the former activity was many -fold greater. Two cathepsin L activities identified in cercarial extracts by zymography co-migrated with activities in extracts of 3 h and 24 h schisotosomula and in extracts of adult worms. Since these enzymes have been implicated in haemoglob in digestion by adult worms, they may perform a similar function in schistosomula. Immunolocalization using scanning electron micrographs showed that cathepsin L and cathepsin B proteinases were present in the cercarial post-acetabular glands. In addition, cercarial serine proteinase activities considered to facilitate skin penetration efficiently cleaved the substrates Z-Gly-Pro-Arg-NHMec and Z-Gly-Pro-Lys-NHMec. Cercariae release most of this serine proteinase activity when induced to secrete the contents of their acetabular glands. In contrast, newly transformed 3 h and 24 h schistosomula did not express this activity.

SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni

2002 ◽  
Vol 121 (1) ◽  
pp. 49-61 ◽  
Author(s):  
Conor R. Caffrey ◽  
Jason P. Salter ◽  
Kimberley D. Lucas ◽  
Dustin Khiem ◽  
Ivy Hsieh ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Cathepsin B

scholarly journals Adjuvanted Schistosoma mansoni-Cathepsin B With Sulfated Lactosyl Archaeol Archaeosomes or AddaVax™ Provides Protection in a Pre-Clinical Schistosomiasis Model

2020 ◽  
Vol 11 ◽  
Author(s):  
Dilhan J. Perera ◽  
Adam S. Hassan ◽  
Yimei Jia ◽  
Alessandra Ricciardi ◽  
Michael J. McCluskie ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Cathepsin B
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