Faculty Opinions recommendation of Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic.

2004 ◽  
Author(s):  
John Kendrick-Jones
Keyword(s):  
Membrane Traffic ◽  
Chemical Genetic ◽  
Myosin Vb

scholarly journals Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic

2004 ◽  
Vol 101 (7) ◽  
pp. 1868-1873 ◽  
Author(s):  
D. William Provance ◽  
Christopher R. Gourley ◽  
Colleen M. Silan ◽  
L. C. Cameron ◽  
Kevan M. Shokat ◽  
...  
Keyword(s):  
Membrane Traffic ◽  
Chemical Genetic ◽  
Myosin Vb

scholarly journals Chemical Genetic Screening Identifies Sulfonamides That Raise Organellar pH and Interfere with Membrane Traffic

Traffic ◽  
2004 ◽  
Vol 5 (7) ◽  
pp. 478-492 ◽  
Author(s):  
Thomas J. F. Nieland ◽  
Yan Feng ◽  
Jing Xu Brown ◽  
Tuan Daniel Chuang ◽  
Peter D. Buckett ◽  
...  
Keyword(s):  
Genetic Screening ◽  
Membrane Traffic ◽  
Chemical Genetic

scholarly journals Glucocorticoids and myosin5b loss of function induce heightened PKA signaling in addition to membrane traffic defects

2019 ◽  
Vol 30 (26) ◽  
pp. 3076-3089 ◽  
Author(s):  
Radia Forteza ◽  
M. Kaimul Ahsan ◽  
Fernando Cartón-García ◽  
Diego Arango ◽  
Nadia A. Ameen ◽  
...  
Keyword(s):  
Apical Membrane ◽  
Membrane Traffic ◽  
Loss Of Function ◽  
Myosin Vb

Loss-of-function mutations in myosin Vb lead to defects in apical membrane traffic in enterocytes in microvillus inclusion disease. This work shows that decreased numbers of apical CFTR molecules are more active for Cl− secretion resulting in profuse diarrhea because of PKA activation in the presence of physiological glucocorticoid concentrations.

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