Faculty Opinions recommendation of Structural basis of long-term potentiation in single dendritic spines.

2004 ◽  
Author(s):  
Kevan A Martin
Keyword(s):  
Dendritic Spines ◽  
Long Term Potentiation ◽  
Structural Basis ◽  
Term Potentiation

scholarly journals Structural basis of long-term potentiation in single dendritic spines

Nature ◽  
2004 ◽  
Vol 429 (6993) ◽  
pp. 761-766 ◽  
Author(s):  
Masanori Matsuzaki ◽  
Naoki Honkura ◽  
Graham C. R. Ellis-Davies ◽  
Haruo Kasai
Keyword(s):  
Dendritic Spines ◽  
Long Term Potentiation ◽  
Structural Basis ◽  
Term Potentiation

scholarly journals Structural changes at dendritic spine synapses during long-term potentiation

2003 ◽  
Vol 358 (1432) ◽  
pp. 745-748 ◽  
Author(s):  
Kristen M. Harris ◽  
John C. Fiala ◽  
Linnaea Ostroff
Keyword(s):  
Dendritic Spines ◽  
Dendritic Spine ◽  
Structural Changes ◽  
Hippocampal Slices ◽  
Long Term Potentiation ◽  
Structural Basis ◽  
Immature Rat ◽  
Term Potentiation ◽  
New Findings

Two key hypotheses about the structural basis of long-term potentiation (LTP) are evaluated in light of new findings from immature rat hippocampal slices. First, it is shown why dendritic spines do not split during LTP. Instead a small number of spine-like dendritic protrusions may emerge to enhance connectivity with potentiated axons. These ‘same dendrite multiple synapse boutons’ provide less than a 3% increase in connectivity and do not account for all of LTP or memory, as they do not accumulate during maturation. Second, polyribosomes in dendritic spines served to identify which of the existing synapses enlarged to sustain more than a 30% increase in synaptic strength. Thus, both enhanced connectivity and enlarged synapses result during LTP, with synapse enlargement being the greater effect.

scholarly journals Long-Term Potentiation in Isolated Dendritic Spines

PLoS ONE ◽  
2009 ◽  
Vol 4 (6) ◽  
pp. e6021 ◽  
Author(s):  
Amadou T. Corera ◽  
Guy Doucet ◽  
Edward A. Fon
Keyword(s):  
Dendritic Spines ◽  
Long Term Potentiation ◽  
Term Potentiation

scholarly journals Chemical LTD, but not LTP, induces transient accumulation of gelsolin in dendritic spines

2019 ◽  
Vol 400 (9) ◽  
pp. 1129-1139 ◽  
Author(s):  
Iryna Hlushchenko ◽  
Pirta Hotulainen
Keyword(s):  
Synaptic Plasticity ◽  
Dendritic Spines ◽  
Hippocampal Neurons ◽  
Long Term Potentiation ◽  
Excitatory Synapses ◽  
Signal Molecule ◽  
Brain Functions ◽  
Dendritic Shaft ◽  
Term Potentiation

Abstract Synaptic plasticity underlies central brain functions, such as learning. Ca2+ signaling is involved in both strengthening and weakening of synapses, but it is still unclear how one signal molecule can induce two opposite outcomes. By identifying molecules, which can distinguish between signaling leading to weakening or strengthening, we can improve our understanding of how synaptic plasticity is regulated. Here, we tested gelsolin’s response to the induction of chemical long-term potentiation (cLTP) or long-term depression (cLTD) in cultured rat hippocampal neurons. We show that gelsolin relocates from the dendritic shaft to dendritic spines upon cLTD induction while it did not show any relocalization upon cLTP induction. Dendritic spines are small actin-rich protrusions on dendrites, where LTD/LTP-responsive excitatory synapses are located. We propose that the LTD-induced modest – but relatively long-lasting – elevation of Ca2+ concentration increases the affinity of gelsolin to F-actin. As F-actin is enriched in dendritic spines, it is probable that increased affinity to F-actin induces the relocalization of gelsolin.

scholarly journals Large and Small Dendritic Spines Serve Different Interacting Functions in Hippocampal Synaptic Plasticity and Homeostasis

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Joshua J. W. Paulin ◽  
Peter Haslehurst ◽  
Alexander D. Fellows ◽  
Wenfei Liu ◽  
Joshua D. Jackson ◽  
...  
Keyword(s):  
Dendritic Spines ◽  
Fluorescent Protein ◽  
Long Term Potentiation ◽  
Functional Differentiation ◽  
Strong Stimulus ◽  
Term Potentiation ◽  
Original Size ◽  
Green Fluorescent ◽  
Homeostatic Response

The laying down of memory requires strong stimulation resulting in specific changes in synaptic strength and corresponding changes in size of dendritic spines. Strong stimuli can also be pathological, causing a homeostatic response, depressing and shrinking the synapse to prevent damage from too much Ca2+influx. But do all types of dendritic spines serve both of these apparently opposite functions? Using confocal microscopy in organotypic slices from mice expressing green fluorescent protein in hippocampal neurones, the size of individual spines along sections of dendrite has been tracked in response to application of tetraethylammonium. This strong stimulus would be expected to cause both a protective homeostatic response and long-term potentiation. We report separation of these functions, with spines of different sizes reacting differently to the same strong stimulus. The immediate shrinkage of large spines suggests a homeostatic protective response during the period of potential danger. In CA1, long-lasting growth of small spines subsequently occurs consolidating long-term potentiation but only after the large spines return to their original size. In contrast, small spines do not change in dentate gyrus where potentiation does not occur. The separation in time of these changes allows clear functional differentiation of spines of different sizes.

scholarly journals Myosin II ATPase Activity Mediates the Long-Term Potentiation-Induced Exodus of Stable F-Actin Bound by Drebrin A from Dendritic Spines

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85367 ◽  
Author(s):  
Toshiyuki Mizui ◽  
Yuko Sekino ◽  
Hiroyuki Yamazaki ◽  
Yuta Ishizuka ◽  
Hideto Takahashi ◽  
...  
Keyword(s):  
Atpase Activity ◽  
Dendritic Spines ◽  
Myosin Ii ◽  
Long Term Potentiation ◽  
Term Potentiation
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