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2022 ◽  
Vol 11 (1) ◽  
pp. 33-49
Muhammad Fahmi ◽  
Sharul Effendy ◽  
Mahaliza Mansor ◽  
Djalal Fuadi ◽  
Harsono Harsono ◽  

<p style="text-align: justify;">Measuring accounting teachers’ professional identity is significant to do as an alternative to measure the professionalism of accounting teachers in Indonesia based on their professional identity. This research was conducted in two stages of exploratory factor analysis involving 150 accounting teachers as sample in each stage. The data were collected in collaboration with an accounting teacher organization, comprising the Accounting Subject Teacher Deliberation (MGMP) in Central Java through a questionnaire. Data analysis was divided into several steps including face validity and content validity, inter-item correlation matrix, and exploratory factor analysis. The results showed that 23 question items encompassed five components of accounting teacher professional identity; Cultural Knowledge (pedagogical cultural identity), Blending (accommodating students' purposes for school in the learning objectives), Identity Experiencing (by the experience of working life in the past, present, and individual expectations in the future in accounting work setting), Inter-Personal Skill, and Active in Professional Communities. The scale development requires continuous development tailing various new findings in the teacher professional identity and accountant professional identity.</p>

Ömer Üstündağ ◽  
Nasim Bakir ◽  
Sergej Gook ◽  
Andrey Gumenyuk ◽  
Michael Rethmeier

AbstractIt is already known that the laser beam welding (LBW) or hybrid laser-arc welding (HLAW) processes are sensitive to manufacturing tolerances such as gaps and misalignment of the edges, especially at welding of thick-walled steels due to its narrow beam diameter. Therefore, the joining parts preferably have to be milled. The study deals with the influence of the edge quality, the gap and the misalignment of edges on the weld seam quality of hybrid laser-arc welded 20-mm-thick structural steel plates which were prepared by laser and plasma cutting. Single-pass welds were conducted in butt joint configuration. An AC magnet was used as a contactless backing. It was positioned under the workpiece during the welding process to prevent sagging. The profile of the edges and the gap between the workpieces were measured before welding by a profile scanner or a digital camera, respectively. With a laser beam power of just 13.7 kW, the single-pass welds could be performed. A gap bridgeability up to 1 mm at laser-cut and 2 mm at plasma-cut samples could be reached respectively. Furthermore, a misalignment of the edges up to 2 mm could be welded in a single pass. The new findings may eliminate the need for cost and time-consuming preparation of the edges.

Information ◽  
2022 ◽  
Vol 13 (1) ◽  
pp. 40
Nemury Silega ◽  
Eliani Varén ◽  
Alfredo Varén ◽  
Yury I. Rogozov ◽  
Vyacheslav S. Lapshin ◽  

The COVID-19 pandemic has caused the deaths of millions of people around the world. The scientific community faces a tough struggle to reduce the effects of this pandemic. Several investigations dealing with different perspectives have been carried out. However, it is not easy to find studies focused on COVID-19 contagion chains. A deep analysis of contagion chains may contribute new findings that can be used to reduce the effects of COVID-19. For example, some interesting chains with specific behaviors could be identified and more in-depth analyses could be performed to investigate the reasons for such behaviors. To represent, validate and analyze the information of contagion chains, we adopted an ontological approach. Ontologies are artificial intelligence techniques that have become widely accepted solutions for the representation of knowledge and corresponding analyses. The semantic representation of information by means of ontologies enables the consistency of the information to be checked, as well as automatic reasoning to infer new knowledge. The ontology was implemented in Ontology Web Language (OWL), which is a formal language based on description logics. This approach could have a special impact on smart cities, which are characterized as using information to enhance the quality of basic services for citizens. In particular, health services could take advantage of this approach to reduce the effects of COVID-19.

2022 ◽  
Vol 23 (2) ◽  
pp. 861
Rui Wu ◽  
Zhixin Liu ◽  
Jiajing Wang ◽  
Chenxi Guo ◽  
Yaping Zhou ◽  

There are numerous exchanges of signals and materials between leaves and roots, including nitrogen, which is one of the essential nutrients for plant growth and development. In this study we identified and characterized the Chlorophyll A/B-Binding Protein (CAB) (named coe2 for CAB overexpression 2) mutant, which is defective in the development of chloroplasts and roots under normal growth conditions. The phenotype of coe2 is caused by a mutation in the Nitric Oxide Associated (NOA1) gene that is implicated in a wide range of chloroplast functions including the regulation of metabolism and signaling of nitric oxide (NO). A transcriptome analysis reveals that expression of genes involved in metabolism and lateral root development are strongly altered in coe2 seedlings compared with WT. COE2 is expressed in hypocotyls, roots, root hairs, and root caps. Both the accumulation of NO and the growth of lateral roots are enhanced in WT but not in coe2 under nitrogen limitation. These new findings suggest that COE2-dependent signaling not only coordinates gene expression but also promotes chloroplast development and function by modulating root development and absorption of nitrogen compounds.

Cells ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 222
Chunmei Fu ◽  
Li Zhou ◽  
Qing-Sheng Mi ◽  
Aimin Jiang

Despite largely disappointing clinical trials of dendritic cell (DC)-based vaccines, recent studies have shown that DC-mediated cross-priming plays a critical role in generating anti-tumor CD8 T cell immunity and regulating anti-tumor efficacy of immunotherapies. These new findings thus support further development and refinement of DC-based vaccines as mono-immunotherapy or combinational immunotherapies. One exciting development is recent clinical studies with naturally circulating DCs including plasmacytoid DCs (pDCs). pDC vaccines were particularly intriguing, as pDCs are generally presumed to play a negative role in regulating T cell responses in tumors. Similarly, DC-derived exosomes (DCexos) have been heralded as cell-free therapeutic cancer vaccines that are potentially superior to DC vaccines in overcoming tumor-mediated immunosuppression, although DCexo clinical trials have not led to expected clinical outcomes. Using a pDC-targeted vaccine model, we have recently reported that pDCs required type 1 conventional DCs (cDC1s) for optimal cross-priming by transferring antigens through pDC-derived exosomes (pDCexos), which also cross-prime CD8 T cells in a bystander cDC-dependent manner. Thus, pDCexos could combine the advantages of both cDC1s and pDCs as cancer vaccines to achieve better anti-tumor efficacy. In this review, we will focus on the pDC-based cancer vaccines and discuss potential clinical application of pDCexos in cancer immunotherapy.

Yongyu He ◽  
Wenqing Xie ◽  
Hengzhen Li ◽  
Hongfu Jin ◽  
Yi Zhang ◽  

Aging promotes most degenerative pathologies in mammals, which are characterized by progressive decline of function at molecular, cellular, tissue, and organismal levels and account for a host of health care expenditures in both developing and developed nations. Sarcopenia is a prominent age-related disorder in musculoskeletal system. Defined as gradual and generalized chronic skeletal muscle disorder, sarcopenia involves accelerated loss of muscle mass, strength and function, which is associated with increased adverse functional outcomes and evolutionally refers to muscle wasting accompanied by other geriatric syndromes. More efforts have been made to clarify mechanisms underlying sarcopenia and new findings suggest that it may be feasible to delay age-related sarcopenia by modulating fundamental mechanisms such as cellular senescence. Cellular senescence refers to the essentially irreversible growth arrest mainly regulated by p53/p21CIP1 and p16INK4a/pRB pathways as organism ages, possibly detrimentally contributing to sarcopenia via muscle stem cells (MuSCs) dysfunction and the senescence-associated secretory phenotype (SASP) while cellular senescence may have beneficial functions in counteracting cancer progression, tissue regeneration and wound healing. By now diverse studies in mice and humans have established that targeting cellular senescence is a powerful strategy to alleviating sarcopenia. However, the mechanisms through which senescent cells contribute to sarcopenia progression need to be further researched. We review the possible mechanisms involved in muscle stem cells (MuSCs) dysfunction and the SASP resulting from cellular senescence, their associations with sarcopenia, current emerging therapeutic opportunities based on targeting cellular senescence relevant to sarcopenia, and potential paths to developing clinical interventions genetically or pharmacologically.

2022 ◽  
Vol 12 (1) ◽  
Daniel Bursák ◽  
Alžběta Danielisová ◽  
Tomáš Magna ◽  
Petr Pajdla ◽  
Jitka Míková ◽  

AbstractAncient brass (aurichalcum) was a valued commodity in the Antiquity, notably because of its gold-like appearance. After mastering brass fabrication using the cementation procedure in the first century BC in the Mediterranean, this material became widely used by the Romans for coins, jewellery and other artefacts. Because of its visual qualities, it is believed that since this period, brass played an important role in diplomatic and economic contacts with indigenous communities, notably Celtic and Germanic tribes north of Danube and west of Rhine. To test this hypothesis, we performed for the first time the advanced statistical multivariate analysis based on chemical composition and lead isotope systematics, coupled with informed typo-chronological categorisation, of a suite of late Iron Age and Early Roman period (first century BC – first century AD) brass and other copper-alloy artefacts from the territory of Bohemia. In order to to discuss their provenance, the results were compared to known contemporary sources of material. The new results for brass artefacts from this early phase of the massive occurrence of Roman aurichalcum in the Barbarian territories point to the ore deposits in the western Mediterranean or the Massif Central area in Gaul, consistent with historical events. These new findings underscore the great economic and political importance of the new and rich mineral resources in the Transalpine Gaul acquired due to Caesar's military campaigns.

2022 ◽  
Saliha Bozkurt ◽  
Berna Toprak ◽  
Hasan Çağrı Yıldırım ◽  
Şafak Parlak ◽  
Deniz Can Güven ◽  

Abstract Introduction: Stroke-like migraine attacks after radiation therapy (SMART) syndrome, is a late complication of brain radiotherapy. (1) Symptoms are commonly subacute in onset and involve migraine type of headache, seizures, focal neurologic deficits.(2) . MRI findings are usually unilateral and posterior predominant cortical-subcortical hyperintensity, swelling and prominent gyriform (cortical and leptomeningeal) gadolinum enhancement in the areas of brain that underwent irradiation with or without diffusion restriction.(1) There is no standard treatment protocol of SMART syndrome. Antiepileptics and corticosteroids are commonly used drugs.Case Report: A 65 years old woman diagnosed with breast cancer with brain metastases and treated with more than 50 Gy brain radiotherapy. A couple of months later patient presented with acute right sided weakness and numbness, episodic myoclonic jerking of the right arm and leg and gait instability. MRI and magnetic resonance angiography of the brain with gadolinium revealed left parietooccipital cortical diffusion restriction and accompanying dilatation of the left posterior cerebral artery as new findings. Computed tomography perfusion revealed increased perfussion in the affected area. The patient was diagnosed with SMART syndrome.Management & Outcome: The patient was treated with dexamethasone (16 mg/day) and anticonvulsant therapy. Myoclonic seizures had almost completely remitted. However, her cognitive impairment persisted, then the patient arrested because of aspiration a month later.Discussion: Besides confirming SMART syndrome, diagnostic investigations is also important to exclude other etiologies. Posterior reversible encephalopathy syndrome, post-ictal changes, meningoencephalitis and cerebrovascular diseases are radiological differential diagnosis which should be considered.(3) Proper and early diagnosis of SMART syndrome is significant to refrain unneccessary aggressive approaches and for appropriate treatment to prevent sequela lesions.

2022 ◽  
Vol 20 (1) ◽  
Chengcheng Xu ◽  
Meng Bao ◽  
Xiaorong Fan ◽  
Jin Huang ◽  
Changhong Zhu ◽  

Abstract Background Intrauterine adhesion (IUA) is one of the leading causes of infertility and the main clinical challenge is the high recurrence rate. The key to solving this dilemma lies in elucidating the mechanisms of endometrial fibrosis. The aim of our team is to study the mechanism underlying intrauterine adhesion fibrosis and the origin of fibroblasts in the repair of endometrial fibrosis. Methods Our experimental study involving an animal model of intrauterine adhesion and detection of fibrosis-related molecules. The levels of molecular factors related to the endothelial-to-mesenchymal transition (EndMT) were examined in a rat model of intrauterine adhesion using immunofluorescence, immunohistochemistry, qPCR and Western blot analyses. Main outcome measures are levels of the endothelial marker CD31 and the mesenchymal markers alpha-smooth muscle actin (α-SMA) and vimentin. Results Immunofluorescence co-localization of CD31 and a-SMA showed that 14 days after moulding, double positive cells for CD31 and a-SMA could be clearly observed in the endometrium. Decreased CD31 levels and increased α-SMA and vimentin levels indicate that EndMT is involved in intrauterine adhesion fibrosis. Conclusions Endothelial cells promote the emergence of fibroblasts via the EndMT during the endometrial fibrosis of intrauterine adhesions.

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