Faculty Opinions recommendation of Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands.

2004 ◽  
Author(s):  
Wolfgang Junge
Keyword(s):  
Potassium Channels ◽  
Dynamic Properties ◽  
Ion Selectivity ◽  
Carbonyl Ligands

Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands

Nature ◽  
2004 ◽  
Vol 431 (7010) ◽  
pp. 830-834 ◽  
Author(s):  
Sergei Yu. Noskov ◽  
Simon Bernèche ◽  
Benoît Roux
Keyword(s):  
Potassium Channels ◽  
Dynamic Properties ◽  
Ion Selectivity ◽  
Carbonyl Ligands

Incidence of partial charges on ion selectivity in potassium channels

2006 ◽  
Vol 124 (4) ◽  
pp. 044703 ◽  
Author(s):  
Philippe Huetz ◽  
Céline Boiteux ◽  
Mylène Compoint ◽  
Christophe Ramseyer ◽  
Claude Girardet
Keyword(s):  
Potassium Channels ◽  
Ion Selectivity ◽  
Partial Charges

Ion selectivity in potassium channels

2006 ◽  
Vol 124 (3) ◽  
pp. 279-291 ◽  
Author(s):  
Sergei Yu. Noskov ◽  
Benoît Roux
Keyword(s):  
Potassium Channels ◽  
Ion Selectivity

Foldamer-Based Potassium Channels with High Ion Selectivity and Transport Activity

2021 ◽  
Author(s):  
Shuaiwei Qi ◽  
Chenyang Zhang ◽  
Hao Yu ◽  
Jing Zhang ◽  
Tengfei Yan ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Ion Selectivity ◽  
Transport Activity

scholarly journals How Does the W434F Mutation Block Current in Shaker Potassium Channels?

1997 ◽  
Vol 109 (6) ◽  
pp. 779-789 ◽  
Author(s):  
Youshan Yang ◽  
Yangyang Yan ◽  
Fred J. Sigworth
Keyword(s):  
Potassium Channels ◽  
Potassium Current ◽  
Xenopus Oocytes ◽  
Single Channel ◽  
Ion Selectivity ◽  
Independent Component ◽  
Single Channel Recordings ◽  
Shaker Channels ◽  
Rapid Inactivation ◽  
Shaker Potassium Channels

The mutation W434F produces an apparently complete block of potassium current in Shaker channels expressed in Xenopus oocytes. Tandem tetrameric constructs containing one or two subunits with this mutation showed rapid inactivation, although the NH2-terminal inactivation domain was absent from these constructs. The inactivation showed a selective dependence on external cations and was slowed by external TEA; these properties are characteristic of C-type inactivation. Inactivation was, however, incompletely relieved by hyperpolarization, suggesting the presence of a voltage-independent component. The hybrid channels had near-normal conductance and ion selectivity. Single-channel recordings from patches containing many W434F channels showed occasional channel openings, consistent with open probabilities of 10−5 or less. We conclude that the W434F mutation produces a channel that is predominantly found in an inactivated state.

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