Faculty Opinions recommendation of Polytheonamides A and B, highly cytotoxic, linear polypeptides with unprecedented structural features, from the marine sponge, Theonella swinhoei.

2005 ◽  
Author(s):  
Tadeusz Molinski
Keyword(s):  
Marine Sponge ◽  
Structural Features ◽  
Theonella Swinhoei

scholarly journals Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella sp.

Marine Drugs ◽  
2021 ◽  
Vol 19 (4) ◽  
pp. 206
Author(s):  
Kuei-Hung Lai ◽  
Zheng-Hao Huang ◽  
Mohamed El-Shazly ◽  
Bo-Rong Peng ◽  
Wen-Chi Wei ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Structural Features ◽  
Chemical Diversity ◽  
Leukemic Cells ◽  
Lead Discovery ◽  
Proliferative Assay

The marine sponge of the genus Geodia, Jaspis, Rhabdastrella, and Stelletta are characterized chemically by a variety of isomalabaricane triterpenes. This class of compounds drew spotlights in marine lead discovery due to their profound anti-proliferative properties. Further research on exploring its chemical diversity led to the identifications of two new isomalabaricane-type triterpenes rhabdastin H (1) and rhabdastin I (2). Their structures were unraveled using a series of spectroscopic approaches. These isolates were found to exhibit unique structural features with the only reported tetrahydrofuran functionality among all marine-derived isomalabaricanes. Both compounds 1 and 2 showed activities against K562 (IC50 11.7 and 9.8 μM) and Molt4 (IC50 16.5 and 11.0 μM) leukemic cells in MTT cell proliferative assay.

scholarly journals Preliminary Structure-Activity Relationship on Theonellasterol, a New Chemotype of FXR Antagonist, from the Marine Sponge Theonella swinhoei

Marine Drugs ◽  
2012 ◽  
Vol 10 (12) ◽  
pp. 2448-2466 ◽  
Author(s):  
Valentina Sepe ◽  
Raffaella Ummarino ◽  
Maria D'Auria ◽  
Orazio Taglialatela-Scafati ◽  
Simona Marino ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Theonella Swinhoei ◽  
Structure Activity

scholarly journals NMR structure of polyiheoamide B from the marine sponge Theonella swinhoei

2003 ◽  
Vol 43 (supplement) ◽  
pp. S40
Author(s):  
M. Fujiwara ◽  
T. Hamada ◽  
K. Fujita ◽  
S. Matsunaga ◽  
N. Fusetani
Keyword(s):  
Marine Sponge ◽  
Nmr Structure ◽  
Theonella Swinhoei

Polytheonamides, unprecedented highly cytotoxic polypeptides, from the marine sponge theonella swinhoei

1994 ◽  
Vol 35 (5) ◽  
pp. 719-720 ◽  
Author(s):  
Toshiyuki Hamada ◽  
Takeo Sugawara ◽  
Shigeki Matsunaga ◽  
Nobuhiro Fusetani
Keyword(s):  
Marine Sponge ◽  
Theonella Swinhoei

Polytheonamides, unprecedented highly cytotoxic polypeptides from the marine sponge Theonella swinhoei 2. Structure elucidation

1994 ◽  
Vol 35 (4) ◽  
pp. 609-612 ◽  
Author(s):  
Toshiyuki Hamada ◽  
Takeo Sugawara ◽  
Shigeki Matsunaga ◽  
Nobuhiro Fusetani
Keyword(s):  
Marine Sponge ◽  
Structure Elucidation ◽  
Theonella Swinhoei

Structures of nine oxygenated 4-methylene sterols from Hachijo marine sponge Theonella swinhoei

Steroids ◽  
1995 ◽  
Vol 60 (11) ◽  
pp. 738-742 ◽  
Author(s):  
Yumi Sugo ◽  
Yoshinobu Inouye ◽  
Noboru Nakayama
Keyword(s):  
Marine Sponge ◽  
Theonella Swinhoei

Nazumazoles A–C, Cyclic Pentapeptides Dimerized through a Disulfide Bond from the Marine Sponge Theonella swinhoei

2015 ◽  
Vol 17 (11) ◽  
pp. 2646-2648 ◽  
Author(s):  
Kazuya Fukuhara ◽  
Kentaro Takada ◽  
Shigeru Okada ◽  
Shigeki Matsunaga
Keyword(s):  
Disulfide Bond ◽  
Marine Sponge ◽  
Theonella Swinhoei

scholarly journals Theonellamide G, a Potent Antifungal and Cytotoxic Bicyclic Glycopeptide from the Red Sea Marine Sponge Theonella swinhoei

Marine Drugs ◽  
2014 ◽  
Vol 12 (4) ◽  
pp. 1911-1923 ◽  
Author(s):  
Diaa Youssef ◽  
Lamiaa Shaala ◽  
Gamal Mohamed ◽  
Jihan Badr ◽  
Faida Bamanie ◽  
...  
Keyword(s):  
Red Sea ◽  
Marine Sponge ◽  
Theonella Swinhoei
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