Faculty Opinions recommendation of Pregnancy associated hormones modulate the cytokine production but not the phenotype of PBMC-derived human dendritic cells.

Author(s):  
Esther Sternberg
2000 ◽  
Vol 164 (4) ◽  
pp. 2193-2199 ◽  
Author(s):  
C. E. Demeure ◽  
H. Tanaka ◽  
V. Mateo ◽  
M. Rubio ◽  
G. Delespesse ◽  
...  

2010 ◽  
Vol 40 (2) ◽  
pp. 505-515 ◽  
Author(s):  
Christelle Langlet ◽  
Cécile Springael ◽  
Jolyn Johnson ◽  
Séverine Thomas ◽  
Véronique Flamand ◽  
...  

2016 ◽  
Vol 68 (12) ◽  
pp. 1604-1612 ◽  
Author(s):  
Bruno J. Conti ◽  
Karina B. Santiago ◽  
Eliza O. Cardoso ◽  
Paula P. Freire ◽  
Robson F. Carvalho ◽  
...  

Author(s):  
S. Laurent ◽  
P. Carrega ◽  
D. Saverino ◽  
P. Piccioli ◽  
M. Camoriamo ◽  
...  

<p>CTLA-4 is the major nefative regulator of T cell response. We have analyzed the expression of CTLA-4 in human monocytes and monocyte-derived DCs and the effects of its engagement on cytokine production and T cell stimulatory activity by mature DCs (mDCs). We found the CTLA-4 was highly expressed on freshly isolated monocytes, then down-modulated on the immature DCs (iDCs) and upregulated on mDCs. Treatment of mDCS with an agonistic anti-CTLA-4 m Ab enhanced secretion of IL-10 but reduced secretion of IL-8 and IL-12, as well as autologous CD4* T-cell proliferation in response to simulation with PPD recall antigenloaded-DCs. Neutralization of IL-10 with an anti-IL-10 antibody partially restored the ability of anti-CTLA-4-treated mDCs to stimulate T cell proliferation in response to PPD. Our data provide the first evidence that CTLA-4 receptor is expressed by human mDCs and exerts immune modulatory effects in these cells.</p>


2001 ◽  
Vol 166 (3) ◽  
pp. 1499-1506 ◽  
Author(s):  
Ling-Jun Ho ◽  
Jaang-Jiun Wang ◽  
Men-Fang Shaio ◽  
Chuan-Liang Kao ◽  
Deh-Ming Chang ◽  
...  

2008 ◽  
Vol 53 (3) ◽  
pp. 359-367 ◽  
Author(s):  
Narintorn Gaudart ◽  
Pattama Ekpo ◽  
Kovit Pattanapanyasat ◽  
Yvette van Kooyk ◽  
Anneke Engering

2013 ◽  
Vol 4 ◽  
Author(s):  
Conti Bruno ◽  
Santiago Karina ◽  
Cardoso Eliza ◽  
Sforcin Jos�

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