Faculty Opinions recommendation of Characteristics of repair tissue in second-look and third-look biopsies from patients treated with engineered cartilage: relationship to symptomatology and time after implantation.

Background Considerable debate exists over the use of radiofrequency-based chondroplasty to treat partial-thickness chondral defects of the knee. This study used second-look arthroscopy to evaluate cartilage defects previously treated with bipolar radiofrequency—based chondroplasty. Hypothesis Partial-thickness articular cartilage lesions treated with bipolar radiofrequency—based chondroplasty will show no progressive deterioration. Study Design Case series; Level of evidence, 4. Methods One hundred ninety-three consecutive patients underwent bipolar radiofrequency—based chondroplasty over 38 months; 15 (25 defects treated with bipolar radiofrequency—based chondroplasty) underwent repeat arthroscopy for recurrent or new injuries. Time from the initial to repeat arthroscopy ranged from 0.7 to 32.7 months. At both procedures, the location, size, grade, and stability of lesions were evaluated, recorded, and photographed arthroscopically. Results At the initial procedure, 25 lesions treated using bipolar radiofrequency—based chondroplasty ranged from 9 to 625 mm2 (mean, 170.2 ± 131.2 mm2; median, 120 mm2); at second look, lesion size was 9 to 300 mm2 (mean, 107.7 ± 106.7 mm2; median, 100 mm2). At second look, 3 (12%) demonstrated unstable borders with damage in the surrounding cartilage that appeared to be progressive. Eight (32%) lesions were unchanged in size. Eight (32%) demonstrated partial filling with stable repair tissue, and 6 (24%) demonstrated complete filling with stable repair tissue. Lesions in the tibiofemoral compartments showed better response to radiofrequency chondroplasty than did those within the patellofemoral joint (P < .05). Conclusion Only 3 of 25 lesions demonstrated progression. More than 50% showed partial or complete filling of the defect. Bipolar radiofrequency chondroplasty is an effective way to treat partial-thickness cartilage lesions; however, long-term effects of this treatment on cartilage remain unknown.

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Morphological MRI and T2 mapping of cartilage repair tissue after mosaicplasty with tissue-engineered cartilage in a pig model

Journal of Biomedical Research ◽

10.7555/jbr.28.20120119 ◽

2014 ◽

Vol 28 (4) ◽

pp. 309-319 ◽

Cited By ~ 8

Author(s):

Qichun Chen

Keyword(s):

Cartilage Repair ◽

T2 Mapping ◽

Pig Model ◽

Repair Tissue ◽

Engineered Cartilage

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Influence of Interleukin Treatment on Engineered and Native Articular Cartilage

ASME 2007 Summer Bioengineering Conference ◽

10.1115/sbc2007-176220 ◽

2007 ◽

Author(s):

Eric G. Lima ◽

Liming Bian ◽

Francis B. Gonzales ◽

Gerard A. Ateshian ◽

Clark T. Hung

Keyword(s):

Articular Cartilage ◽

Cartilage Repair ◽

Biochemical Properties ◽

Inflammatory Factors ◽

Stages Of Development ◽

Repair Tissue ◽

Native Cartilage ◽

Diarthrodial Joint ◽

Inflammatory Molecules ◽

Engineered Cartilage

Injury to the diarthrodial joint is often associated with elevated levels of cytokines and other inflammatory molecules. While the influence of interleukin on articular cartilage has been well-studied, its effects on engineered cartilage are not. The presence of inflammatory factors in the injured joint would be expected to affect the performance of implanted engineered cartilage repair tissue [1] and this effect may be especially pronounced in underdeveloped tissues [2]. The current study addresses this issue by examining the influence of interleukin (IL-1α and IL-1β) on engineered cartilage mechanical and biochemical properties at sequential stages of development. Furthermore, dexamethasone, an anti-inflammatory steroid that has been shown in some cases to suppress interleukin-induced degradation of native cartilage [3], was examined in the context of engineered constructs.

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