Faculty Opinions recommendation of Diagnostic value of N-methyl-D-aspartate receptor antibodies in women with new-onset epilepsy.

2009 ◽  
Author(s):  
Massimo Pandolfo ◽  
Chantal Depondt
Keyword(s):  
Diagnostic Value ◽  
Aspartate Receptor ◽  
Receptor Antibodies ◽  
New Onset

scholarly journals Diagnostic Value of N-methyl-D-aspartate Receptor Antibodies in Women With New-Onset Epilepsy

2009 ◽  
Vol 66 (4) ◽  
Author(s):  
Pitt Niehusmann ◽  
Josep Dalmau ◽  
Christian Rudlowski ◽  
Angela Vincent ◽  
Christian E. Elger ◽  
...  
Keyword(s):  
Diagnostic Value ◽  
Aspartate Receptor ◽  
Receptor Antibodies ◽  
New Onset

Psychosis Associated with Anti-N-methyl-d-aspartate Receptor Antibodies

CNS Spectrums ◽  
2008 ◽  
Vol 13 (8) ◽  
pp. 699-703 ◽  
Author(s):  
Kevin M. Nasky ◽  
Douglas R. Knittel ◽  
Gail H. Manos
Keyword(s):  
Clinical Response ◽  
Mental Status ◽  
Intravenous Immunoglobulins ◽  
Subsequent Treatment ◽  
Psychotic Symptoms ◽  
Prodromal Phase ◽  
Aspartate Receptor ◽  
Receptor Antibodies ◽  
New Onset

ABSTRACTWe describe the eighth case study of a female diagnosed with anti-N-methyl-d-aspartate receptor encephalitis without an identified tumor who presented with floridly psychotic symptoms following a 2-week prodromal phase with new-onset headaches and presyncopal episodes. While hospitalized, the patient had seizures, autonomic dysfunction, involuntary movements, and a decline in mental status. A subsequent assay was positive for anti-N-methyl-d-aspartate receptor antibodies. In contrast to most reported cases, an initial trial with corticosteroids was therapeutically unsuccessful. Subsequent treatment with intravenous immunoglobulins, however, resulted in a prompt, robust clinical response and enabled the patient to be rapidly discharged from the hospital, with minimal neuropsychiatrie sequelae.

Pure ataxia associated with N-methyl-d-aspartate receptor antibodies

2014 ◽  
Vol 20 (5) ◽  
pp. 568-569 ◽  
Author(s):  
Diana Aguiar de Sousa ◽  
Patrícia Pita Lobo ◽  
Ana Castro Caldas ◽  
Miguel Coelho ◽  
Luísa Albuquerque
Keyword(s):  
Aspartate Receptor ◽  
Receptor Antibodies

Anti-N-Methyl-D-Aspartate Receptor Encephalitis in a 3-Year-Old Toddler with the Involvement of Severe Autonomic Dysfunctions in Gastrointestinal System: A Case Report

2018 ◽  
Vol 17 (01) ◽  
pp. 041-044 ◽  
Author(s):  
Li-Ying Liu ◽  
Yang-Yang Wang ◽  
Ling-Yu Pang ◽  
Gui-Xia Zhang ◽  
Li-Ping Zou
Keyword(s):  
Gastrointestinal System ◽  
Immunomodulatory Treatment ◽  
Gastrointestinal Dysmotility ◽  
System A ◽  
Aspartate Receptor ◽  
Nmdar Encephalitis ◽  
Rare Manifestation ◽  
Autonomic Dysfunctions ◽  
First Onset ◽  
Receptor Antibodies

AbstractAnti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is under-recognized in children and adults. It is characterized by prominent neurologic and psychiatric features at first onset. Autonomic manifestations are rarer in children than in adults. We report a 3-year-old male patient with rare manifestation of severe autonomic dysfunctions of the gastrointestinal system and atypical prodromal symptoms. The serum and CSF of the patient were positive for anti-NMDA receptor antibodies, and his electroencephalogram results showed an “extreme delta brush” pattern. The patient had completely recovered by the sixth-month assessment after receiving first-line immunomodulatory treatment. Thus, anti-NMDAR encephalitis should be considered in the differential diagnosis of children with mental status changes and widespread autonomic dysfunction, particularly if symptoms are accompanied by gastrointestinal dysmotility and anhidrosis.

scholarly journals Is the History of Erectile Dysfunction a Reliable Risk Factor for New Onset Acute Myocardial Infarction? A Systematic Review and Meta-Analysis

2020 ◽  
Vol 14 (3) ◽  
pp. 122-129
Author(s):  
Ahmed Adam ◽  
Jared McDowall ◽  
Sunday Joseph Aigbodion ◽  
Callistus Enyuma ◽  
Sean Buchanan ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Systematic Review ◽  
Acute Myocardial Infarction ◽  
Risk Factor ◽  
Erectile Dysfunction ◽  
Meta Analysis ◽  
Diagnostic Value ◽  
True Negative ◽  
History Of ◽  
New Onset

Acute myocardial infarction (AMI) occurs as a manifestation of coronary atherosclerotic disease. The occurrence of erectile dysfunction (ED) following AMI is well documented and this association and pathophysiology is often interrelated. Few studies have objectively assessed the diagnostic value of ED as a risk factor for AMI, in general. In this review, we aimed to better outline the diagnostic predictability of ED as a precursor for ‘first/new onset' AMI. This review was performed using selective search terms, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. The Cochrane, Embase, PubMed, Scopus and Web of Science databases were searched (September 2018). Selected studies were further assessed for relevance and quality (Critical Appraisal Skills Program tool-Oxford). Four studies [573 participants; mean 143 (SD ± 76.3604) and median 141 participants] were eligible for analysis. Meta-analysis of the studies resulted in a pooled sensitivity of 51.36% (95% CI: 47.37-55.33%). For the single study which reported true negative and false positive cases, a specificity of 76.53% (95% CI: 68.57-83.00%) was calculated. The results of this systematic review and meta-analysis suggest that a history of ED should be used as a risk factor for new onset AMI.

THUR 154 NMDAR-AB encephalitis: frequency of diagnosis and outcomes

2018 ◽  
Vol 89 (10) ◽  
pp. A18.3-A18
Author(s):  
Lim H ◽  
Whittam D ◽  
Jackson E ◽  
Williams N ◽  
O’Connell D ◽  
...  
Keyword(s):  
Oligoclonal Bands ◽  
Symptom Duration ◽  
Onset Age ◽  
Significant Delay ◽  
Mri Brain ◽  
Aspartate Receptor ◽  
Csf Pleocytosis ◽  
Intrathecal Oligoclonal Bands ◽  
Receptor Antibodies

BackgroundThe association of N-methyl d-aspartate receptor-antibodies (NMDAR-Abs) and encephalitis is now well recognised. MethodsRetrospective review of frequency of diagnosis and outcomes in encephalitis with NMDAR-Abs identified at the Walton Centre between 2012–2017.ResultsNMDAR-Abs were detected in 29/1131 (3%) of sera and/or CSF samples. Of 20 (69%) patients with encephalitis, 50% were identified in the last two years. Median onset age was 34(17–75) years and 60% (12/20) were female. Median symptom duration before diagnosis was 24(2–720) weeks between 2012–2015, improving to 14(1–96) weeks between 2015–2016. Five patients (25%) had an infectious prodrome (one prior HSV-1 encephalitis). Psychiatric/cognitive symptoms, seizures, and movement disorders were present in 80% (16/20), 70% (14/20), and 55% (11/20) of patients respectively. Three patients had ovarian teratomas.Electroencephalograms were abnormal in 65% (15/23) and MRI brain in 37% (7/19) patients. Unmatched intrathecal oligoclonal bands and CSF pleocytosis were present in 31% (5/16) and 60% (15/25) of samples respectively. Immunotherapy was beneficial in 73% (11/15) of patients. Two patients died (sepsis and multi-organ failure) and two improved spontaneously. At a median follow-up of 9 (5–180) months, 69% (11/16) of patients had an mRS ≤2. ConclusionAlthough the recognition of NMDAR-Ab encephalitis has improved, there is still a significant delay to diagnosis. The majority of patients have good outcomes.

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