Faculty Opinions recommendation of Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53.

The incidence of thyroid cancer has almost doubled in recent years and over 60,000 people will be diagnosed in the US in 2015. While the prognosis for most such patients is excellent, a significant proportion die of thyroid cancer from local tumor progression and above all from metastases. Here we review the different types of thyroid cancers and their molecular changes with a special emphasis on the currently known susceptibility and precipitating factors. With the recent clinical introduction of tyrosine kinase inhibitors for the treatment of metastatic thyroid cancer it is clear that a simple cure is not at hand and further understanding of the molecular mechanisms of these tumors is urgently needed.

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Cancer risks in thyroid cancer patients

British Journal of Cancer ◽

10.1038/bjc.1991.261 ◽

1991 ◽

Vol 64 (1) ◽

pp. 159-163 ◽

Cited By ~ 70

Author(s):

P Hall ◽

L-E Holm ◽

G Lundell ◽

G Bjelkengren ◽

L-G Larsson ◽

...

Keyword(s):

Thyroid Cancer ◽

Cancer Patients ◽

Cancer Risks

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Assessment of Lifetime Attributable Risk for Public Health Sustainability from the Fukushima Accident

Science and Technology of Nuclear Installations ◽

10.1155/2020/8873031 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Faith Rukundo ◽

Juyoul Kim

Keyword(s):

Risk Assessment ◽

Thyroid Cancer ◽

Nuclear Power ◽

Assessment Tool ◽

Radiation Risk ◽

World Health ◽

Cancer Risks ◽

Fukushima Accident ◽

Males And Females ◽

Health Organization

The study aimed at reassessing the radiological risk from exposure to ionizing radiation from Fukushima Daiichi nuclear power plant accident. The estimated risks from the study were compared with World Health Organization (WHO) risk assessment estimates for validity and verification. A Radiation Risk Assessment Tool (RadRAT) was used to estimate Lifetime Attributable Risks (LAR) of cancer upon exposure. All solid cancers, leukemia, and thyroid cancer risks for ages of 1, 10, and 20 years (infants, children, and adults) in 100,000 persons at exposure were estimated. For solid cancers, LAR (10−2) was estimated in a range of 0.223∼0.668 and 0.345∼1.24 for males and females, respectively, whereas the LAR (10−2) for leukemia was estimated at 0.0155∼0.055 and 0.0118∼0.0375 for males and females, respectively. LAR (10−2) for thyroid cancer ranged from 0.0722∼0.545 and 0.0369∼0.265, respectively.

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