This chapter provides a summary of the landmark study known as the EDEN trial. In patients with acute lung injury (ALI) and without malnutrition does trophic enteral feeding during the first 6 days of critical illness increase ventilator-free days (VFDs) and decrease gastrointestinal intolerance compared with full enteral feeding? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter then briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.
Initial Trophic vs Full Enteral Feeding in Patients With Acute Lung Injury: The EDEN Randomized Trial