Faculty Opinions recommendation of Subcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression.

2012 ◽  
Author(s):  
Thomas E Schlaepfer
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Bipolar Depression ◽  
Treatment Resistant ◽  
Deep Brain

Deep brain stimulation for bipolar disorder—review and outlook

CNS Spectrums ◽  
2016 ◽  
Vol 22 (3) ◽  
pp. 254-257 ◽  
Author(s):  
Sabrina M. Gippert ◽  
Christina Switala ◽  
Bettina H. Bewernick ◽  
Sarah Kayser ◽  
Alena Bräuer ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Depressive Symptomatology ◽  
Bipolar Depression ◽  
Single Case ◽  
Treatment Resistant ◽  
Stimulation Parameters ◽  
Antidepressant Efficacy ◽  
Deep Brain

Research on deep brain stimulation (DBS) for treatment-resistant psychiatric disorders has established preliminary efficacy signals for treatment-resistant depression. There are only few studies on DBS that included patients suffering from bipolar disorder. This article gives an overview of these studies concerning DBS targets, antidepressant efficacy, and the occurrence of manic/hypomanic symptoms under stimulation. First, promising results show that all patients experienced significant improvement in depressive symptomatology. In a single case, hypomanic symptoms occurred, but they could be resolved by adjusting stimulation parameters. Furthermore, this article highlights important clinical differences between unipolar and bipolar depression that have to be considered throughout the course of treatment.

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