Faculty Opinions recommendation of The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment.

Author(s):  
Diego Kyburz
2015 ◽  
Vol 35 (4) ◽  
pp. 291-299 ◽  
Author(s):  
Elnaz Vaghef-Mehrabany ◽  
Aziz Homayouni-Rad ◽  
Beitullah Alipour ◽  
Sakineh-Khatoun Sharif ◽  
Leila Vaghef-Mehrabany ◽  
...  

1975 ◽  
Vol 3 (3) ◽  
pp. 158-171 ◽  
Author(s):  
G L Royer ◽  
T E Moxley ◽  
M S Hearron ◽  
A Miyara ◽  
B M Shenker

Two-hundred and eighteen individuals with rheumatoid arthritis were randomly assigned to six months treatment with ibuprofen (900-1800 mg/day) or indomethacin (75-150 mg/day). The drugs were equally effective in the treatment of rheumatoid arthritis while the incidence of indomethacin side-effects was 1·5 times greater than the incidence of ibuprofen side-effects.


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