Faculty Opinions recommendation of Positive effect of abdominal breathing exercise on gastroesophageal reflux disease: a randomized, controlled study.

2012 ◽  
Author(s):  
Jonathan Markowitz
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Breathing Exercise ◽  
Randomized Controlled ◽  
Abdominal Breathing ◽  
Positive Effect

scholarly journals Omeprazole-Domperidone Fixed Dose Combination vs Omeprazole Monotherapy: A Phase 4, Open-Label, Comparative, Parallel Randomized Controlled Study in Mild to Moderate Gastroesophageal Reflux Disease

2017 ◽  
Vol 10 ◽  
pp. 117955221770945 ◽  
Author(s):  
KY Marakhouski ◽  
GA Karaseva ◽  
DN Ulasivich ◽  
Y Kh Marakhouski
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Combined Therapy ◽  
Fixed Dose ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Reflux Symptoms ◽  
Group 2 ◽  
Group 1

Aim: To compare the efficacy and safety of omeprazole-domperidone combination vs omeprazole monotherapy in gastroesophageal reflux disease (GERD). Methods: In a comparative, randomized controlled, phase 4 study, outpatients with GERD were randomly allocated to either group 1 (omeprazole 20 mg + domperidone 30 mg) or group 2 (omeprazole 20 mg) in an equal ratio; 2 capsules daily in the morning were administered for 8 weeks. Results: Sixty patients were enrolled. Esophagitis reversal was observed in 92% patients in group 1 vs 65.2% in group 2. Approximately, 83.3% patients in group 1 vs 43.3% patients in group 2 demonstrated full cupping of reflux symptoms at 8 weeks. Combined therapy resulted in significantly longer period of heartburn-free days (23 vs 12 days on omeprazole). There were no safety concerns. Conclusions: Omeprazole-domperidone combination was more effective than omeprazole alone in providing complete cupping of reflux symptoms and healing of esophagitis in patients with GERD. Both the treatments were well tolerated with few reports of adverse events. Trial registration: This trial is registered with http://clinicaltrials.gov , number NCT02140073.

Sign in / Sign up

Export Citation Format

Share Document