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Retos ◽  
2022 ◽  
Vol 44 ◽  
pp. 789-795
Elisa Fiore ◽  
Camilo Corbellini ◽  
Lara Acucella ◽  
Stefano Gargano ◽  
Eleuterio Sánchez Romero ◽  

  Objective: This review aimed to provide an update on the characterization and impact of musculoskeletal pain in COVID-19 survivors. Methods: It is considered articles on subjects who had been recovered from COVID-19 infection after hospitalization (COVID-19 survivors) with secondary musculoskeletal pain. Results: Six articles (one editorial, one consensus statement, one letter to the editor, one case-control study, one cohort study and one review) showed the polyhedral effects of the SARS-CoV-2 on musculoskeletal pain. This short review was not able to clearly identify what the pathogenesis of musculoskeletal pain was in COVID-19 survivors. Conclusion: Preliminary data showed that widespread pain similar to the pattern compatible with pain of musculoskeletal origin could characterize symptoms after SARS-CoV-2 infection.  Resumen. Objetivo: Esta revisión tuvo como objetivo proporcionar una actualización sobre la caracterización y el impacto del dolor musculoesquelético en los supervivientes de COVID-19. Métodos: Se consideraron artículos sobre sujetos que se recuperaron de la infección por COVID-19 tras la hospitalización (supervivientes de COVID-19) con dolor musculoesquelético secundario. Resultados: Seis artículos (un editorial, una declaración de consenso, una carta al editor, un estudio de casos y controles, un estudio de cohortes y una revisión) mostraron los efectos poliédricos del SARS-CoV-2 sobre el dolor musculoesquelético.  Esta breve revisión no pudo identificar claramente cuál era la patogénesis del dolor musculoesquelético en los supervivientes del COVID-19. Conclusión: Los datos preliminares mostraron que el dolor generalizado similar al patrón compatible con el dolor de origen musculoesquelético podría caracterizar los síntomas después de la infección por SARS-CoV-2.

2022 ◽  
Vol 54 (4) ◽  
pp. 292-299
Imran Hameed

For cardiac evaluation echocardiography is of immense importance. Easy availability, low cost, and portability lands it in the hands of novices at times. It has a learning curve and expertise must be obtained to keep the standard of reports high and reliable. The referring physician must be fully conversant with the indications of echocardiography. The echocardiographic machine should deliver images of high resolution and fully equipped with all the basic modalities. Availability of 3D (3-dimensional) imaging, tissue synchronization imaging and strain analysis are added advantages. Preliminary data of patient must be collected and the study should be recorded for off-line analysis. Finally, the findings should be narrated on a proforma in the form of a standardized report showing all the relevant features, especially directed to the query of referring physician, thus completing the loop.

Biomolecules ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 87
Gennaro Lettieri ◽  
Nadia Carusone ◽  
Rosaria Notariale ◽  
Marina Prisco ◽  
Alessia Ambrosino ◽  

Mercury is one of the most dangerous environmental pollutants. In this work, we analysed the effects of exposure of Mytilus galloprovincialis to 1, 10 and 100 pM HgCl2 for 24 h on the gonadal morphology and on the expression level of three stress genes: mt10, hsp70 and πgst. In this tissue we also evaluated the level of steroidogenic enzymes 3β-HSD and 17β-HSD and the expression of PL protein genes. Finally, we determined difference in sperm chromatin accessibility to micrococcal nuclease. We found alterations in gonadal morphology especially after exposure to 10 and 100 pM HgCl2 and hypo-expression of the three stress genes, particularly for hsp70. Furthermore, decreased labelling with both 3β-HSD and 17β-HSD antibodies was observed following exposure to 1 and 10 pM HgCl2 and complete absence at 100 pM HgCl2 exposure. Gonads of mussels exposed to all HgCl2 doses showed decreased expression of PL protein genes especially for PLIII. Finally, micrococcal nuclease digestions showed that all doses of HgCl2 exposure resulted in increased sperm chromatin accessibility to this enzyme, indicative of improper sperm chromatin structure. All of these changes provide preliminary data of the potential toxicity of mercury on the reproductive health of this mussel.

2022 ◽  
Athanasios MANOURAS ◽  

V. Krylov ◽  
E. Izvekov ◽  
V. Pavlova ◽  
N. Pankova ◽  
E. Osipova

The locomotor activity of zebrafish (Danio rerio) has a pronounced, well-studied circadian rhythm. Under constant illumination, the period of free-running locomotor activity in this species usually becomes less than 24 hours. To evaluate the entraining capabilities of slow magnetic variations, zebrafish locomotor activity was evaluated at constant illumination and fluctuating magnetic field with a period of 26.8 hours. Lomb-Scargle periodogram revealed significant free-running rhythms of locomotor activity and related behavioral endpoints with a period close to 27 hours. Obtained results reveal the potential of slow magnetic fluctuations for entrainment of the circadian rhythms in zebrafish. The putative mechanisms responsible for the entrainment are discussed, including the possible role of cryptochromes.

Hira Fitriani Aisyah

Latar Belakang. Wilayah Jakarta Timur menduduki posisi lokasi fokus stunting, salah satunya di Kelurahan Tengah. Berdasarkan pengolahan data awal, diketahui prevalensi stunting pada enam posyandu di dua RW terpilih mencapai angka 25,9%.Tujuan. Mengetahui perbandingan pola asuh balita stunting dan tidak stunting di Kelurahan Tengah, Kecamatan Kramat Jati Metode. Penelitian kualitatif dengan pendekatan studi kasus melalui wawancara mendalam secara daring. Sampel dipilih secara purposive sampling sesuai kriteria inklusi dan eksklusi dengan 12 informan utama yang memiliki balita stunting dan tidak stunting usia 24-59 bulan, serta informan kunci terdiri dari, Tenaga Pelaksana Gizi dan kader posyandu.Hasil. Hasil penelitian terhadap informan utama dengan balita stunting menunjukkan bahwa sebagian besar ibu tidak memberikan ASI Eksklusif kepada anaknya, memberikan makan dengan frekuensi yang kurang, variasi makanan tidak beragam karena anak banyak diberikan jajanan. Selain itu, ibu dengan anak stunting juga mendapatkan dukungan psikososial yang rendah serta rendahnya partisipasi ke Posyandu.Kesimpulan. Terdapat perbedaan antara pola asuh ibu dengan balita stunting dan ibu dengan balita tidak stunting. ABSTRACTBackground. East Jakarta region has become the primary location of stunting, one of which is Tengah Village. Based on the weighing and preliminary data, the prevalence of stunting in 6 Posyandu in the two selected RWs reached 25.9%. Objective to find out the comparison of parenting patterns of stunting toddlers and non-stunting toddlers in Tengah Urban-Village, Kramat Jati Sub-District Method. This research is qualitative, with a case-study approach and collected through in-depth online interviews. The sample was selected by purposive sampling, based on the inclusion and exclusion criteria which 12 main informants had stunting and not stunting toddlers aged 24-59 months and key informants consisting of Nutrition Workers in the Puskesmas Tengah and Posyandu cadres. Results. The research results on key informants with stunting toddlers show that most mothers didn’t give exclusive breastfeeding to their children, provide food with less frequency, food variations are not varied because children are given a lot of snacks. Mothers with stunting toddlers also experienced low psychosocial support and low participation in Posyandu.Conclusion. There is a difference between mothers with stunting toddlers' parenting patterns and mothers with non-stunting toddlers.  

2021 ◽  
Vol 12 (1) ◽  
pp. 8
Paolo Alfieri ◽  
Francesco Scibelli ◽  
Laura Casula ◽  
Simone Piga ◽  
Eleonora Napoli ◽  

Children with fragile X syndrome and William Beuren syndrome share several socio-communicative deficits. In both populations, around 30/35% of individuals meets criteria for autism spectrum disorder on gold standard instruments. Notwithstanding, few studies have explored feasibility and validity of therapy for socio-communicative deficits in individuals with these genetic conditions. In this study, we present preliminary data on a pilot RCT aimed to verify the effectiveness of cooperative parent-mediated therapy for socio-communicative deficits in a transdiagnostic perspective in a small sample of 12 participants. Our preliminary data showed that the experimental group had significant improvement in one socio-communicative skill (responsivity) and in clinical global impression, while the control group in an adaptive measure of socialization and word production. Implications of these results are then discussed.

2021 ◽  
Vol 12 ◽  
Élise Marsollier ◽  
Denis Hauw ◽  
Fabienne Crettaz von Roten

Facing the important methodological limitations of the instruments used for assessing the prevalence of interpersonal violence faced by young athletes, the aim of the present study was to propose and describe the use of a research instrument adapted to young and French-speaking athletes. In addition, by collecting preliminary data with a Swiss sample, we aimed to measure the different forms of interpersonal violence young athletes have experienced at least once during their sport practice. Our questionnaire was based on three existing questionnaires and adapted for a young audience. Regarding prevalence, results showed that among the 210 respondents, 75% declared psychological violence, 53% physical violence, 28% sexual violence and 21% reported no violence. The other results showed that this instrument appears to be well-structured to measure interpersonal violence and understandable for young athletes. Based on the strengths and limits of our instrument, the methodological need of standardization of research instruments is discussed in line with a need of more studies to fully understand the phenomenon.

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