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2021 ◽  
Vol 22 (20) ◽  
pp. 10996
Author(s):  
Maria Giovanna Francipane ◽  
Bruno Douradinha ◽  
Cinzia Maria Chinnici ◽  
Giovanna Russelli ◽  
Pier Giulio Conaldi ◽  
...  

Glioblastoma (GBM) is the most aggressive among the neurological tumors. At present, no chemotherapy or radiotherapy regimen is associated with a positive long-term outcome. In the majority of cases, the tumor recurs within 32–36 weeks of initial treatment. The recent discovery that Zika virus (ZIKV) has an oncolytic action against GBM has brought hope for the development of new therapeutic approaches. ZIKV is an arbovirus of the Flaviviridae family, and its infection during development has been associated with central nervous system (CNS) malformations, including microcephaly, through the targeting of neural stem/progenitor cells (NSCs/NPCs). This finding has led various groups to evaluate ZIKV’s effects against glioblastoma stem cells (GSCs), supposedly responsible for GBM onset, progression, and therapy resistance. While preliminary data support ZIKV tropism toward GSCs, a more accurate study of ZIKV mechanisms of action is fundamental in order to launch ZIKV-based clinical trials for GBM patients.


2021 ◽  
Vol 24 (1) ◽  
Author(s):  
Jessica Lange ◽  
Sarah Severson

The dominance of commercial publishers (Larivière, Haustein, and Mongeon 2015) has led to a discussion in Canada focusing on alternative models for supporting independent, non-commercial, scholarly journals. Although small in number, these journals represent an important contribution to Canadian and global scholarship. They also act as a counterbalance to the increasingly for-profit nature of scholarly publishing. Despite their importance, there exists no definitive list of journals of this nature in Canada, making analysis and understanding of their characteristics difficult.In order to address this gap, the researchers undertook an analysis of the websites of 485 Canadian, independent, scholarly journals. Independent was defined as journals which are not affiliated with a commercial publisher. The researchers gathered data for each journal on their access type (e.g., closed, open access), subject area, size and composition of the editorial team, and any affiliation(s). This data was then analyzed to create a portrait of these journals with these themes. The researchers found that most of these journals were affiliated with at least one organization, with over half being associated with two or more. They also discovered that affiliations varied depending on the discipline and that the size of the editorial team was correlated to the access type. Journals were predominantly in the humanities and social sciences, and the majority were open access (OA) without article processing charges (APCs).While the focus of this study is on Canadian journals, this article provides a framework for other researchers to examine non-commercial, independent publishing in their own countries. Its results also provide preliminary data which may inspire future avenues of research, particularly into models for non-APC, open access journals as well as the editorial board structure and size for independent journals.


2021 ◽  
Vol 13 (4) ◽  
pp. 15
Author(s):  
Nawal Hamid Mohammed Hamid

This research aimed to investigate the level of test anxiety and the relationship between test anxiety and self-esteem among the students of the faculty of Science and Arts in Rafha campus, Northern Border University, KSA during the COVID-19 pandemic. In addition, it intended to identify the differences in test anxiety among the students according to gender variable. The researcher applied the descriptive method, prepared a preliminary data form, and used the Westside Test Anxiety Scale by Driscoll (2007) and the Self-esteem Scale by El Sayed (2019). The data were collected online, and the sample size was (336) students. The results showed that the level of test anxiety among the students of the faculty of Science and Arts during the COVID-19 pandemic was high. The correlation coefficient between the impairment subscale and self-esteem was negative but statistically insignificant. Moreover, the correlation coefficients between both the worry subscale and the test anxiety total scores with the self-esteem resulted in a negative sign and statistically significant. There were significant differences in test anxiety among the students in the impairment subscale, the P-value was (0.005), which indicates that the difference between the two means is statistically significant, and the males’ mean is greater. While the P-value for the worry subscale was (0.226), which indicates that the difference was insignificant, the P-value of the test anxiety total scores was (0.029), which reveals that the difference between the two means is statistically significant, and the males’ mean is greater.


2021 ◽  
Vol 16 (1) ◽  
pp. 45-51
Author(s):  
MM Bodiuzzaman

COVID-19 is primarily a respiratory disease caused by a newly discovered SARS-CoV-2 virus and identified in the city of Wuhan, China in December 2019. World Health Organization (WHO) has declared this disease as a pandemic, and warned other countries. Presently this has affected 221 countries, areas or territories worldwide, Spreading of this disease is very fast in USA, India, Brazil, and Russia than in the country of its origin China. Like other coronaviruses, this may develop respiratory tract infections in the patients range from mild to fatal illness like pneumonia and acute respiratory distress syndrome (ARDS). Bangladesh, a country of 170 million people, is not an exception regarding COVID-19; it has been reported 5,70,800 confirmed cases with 8690 documented deaths. Still now no effective drug, vaccine, or any procedure is available and experiments are underway. However, empirical therapy is being followed to manage and save the lives of the patients. There is a need for pharmacological alternatives to combat this deadly virus and its complications. Based on the previous experiences with similar coronavirus management and present preliminary data from uncontrolled studies, drugs like Chloroquine, Hydroxychloroquine, Remdesivir, Lopinavir/Ritonavir, and Favipiravir have been recommended by the researchers to manage COVID-19. This review had assessed the potential mechanisms, safety profile, availability and cost of these drugs. This review concludes that the drugs mentioned above are having different properties and act differently in combating the COVID-19 viruses. Faridpur Med. Coll. J. 2021;16(1):45-51


2021 ◽  
Vol 90 ◽  
pp. 267-268
Author(s):  
K. Theunissen ◽  
G. Plasqui ◽  
P. Meyns ◽  
A. Boonen ◽  
A. Timmermans ◽  
...  

Author(s):  
Aleah S. Brock ◽  
Sandie M. Bass-Ringdahl

Purpose This research note reports preliminary data from an investigation of facilitative language techniques (FLTs) used in the natural environment by caregivers of children who are deaf or hard of hearing (DHH). The investigation seeks to establish a new method to collect and analyze data on caregiver FLT use in the home. Method This pilot investigation included two children under the age of 36 months with moderate-to-profound sensorineural hearing loss. Both children were consistent users of hearing devices and were pursing oral communication. Data were collected via the Language ENvironment Analysis (LENA) system in the participants' homes. Thirty-six 5-min segments containing the highest adult word count were extracted from each participant's sample. Researchers coded segments for the presence or absence of 10 FLTs within 30-s intervals. Results The collection, coding, and analysis of caregiver FLTs using LENA was a feasible method to investigate caregiver linguistic input in the natural environment. Despite differences in age, sex, and hearing level, the distribution of caregiver FLTs was similar for both participants. Caregivers used high levels of narration, closed-ended questions, and directives throughout the day. Conclusions Results of this investigation provide information about the types of FLTs that are used in the home by caregivers of young children who are DHH. Furthermore, results indicate the feasibility of this method to investigate in-home use of caregiver FLTs.


2021 ◽  
Vol 6 (3) ◽  
pp. 224-229
Author(s):  
Aldona Kubica ◽  
Piotr Michalski ◽  
Michał Kasprzak ◽  
Przemysław Podhajski ◽  
Łukasz Pietrzykowski ◽  
...  
Keyword(s):  

2021 ◽  
Vol 65 (3) ◽  
pp. 241-246
Author(s):  
Vlad-Ioan Suciu ◽  
Corina-Iuliana Suciu ◽  
Simona Delia Nicoară ◽  
Lăcrămioara Perju-Dumbravă

2021 ◽  
Vol 31 (3) ◽  
pp. 529-536
Author(s):  
Bogdan PAVEL ◽  
◽  
Mihaela Roxana POPESCU ◽  
Carmen-Denise-Mihaela ZAHIU ◽  
Patricia Demetria POPOVICI ◽  
...  

Heart rate variability (HRV) has long been associated with cardiovascular risk, especially after a myocardial infarction, but also in general. HRV refl ects and is used as a surrogate for the balance between sympathetic and parasympathetic systems in modulating the cardiovascular activity. A low HRV, traditionally associated to sympathovagal imbalance, is associated with a worse cardiovascular prognosis. Deep brain stimulation (DBS) is a surgical technique used for severe cases of Parkinson’s disease and other neurologic pathologies. DBS is performed in various areas of the brain and through different protocols. The claustrum, an area located between the external capsule and the insular cortex, was recently shown to be connected to Parkinson’s motor symptoms. As DBS in other regions of the brain has proven non-motor effects, like infl uencing the HRV, we sought to document the effect of claustrum stimulation on the sympatho-vagal balance (SVB). Our preliminary data indicates that claustrum stimulation inclines the SVB toward the latter, but more studies are required to observe the long-term effects of this type of stimulation.


Author(s):  
Vu Thi Thu ◽  
Ngo Thi Hai Yen

This study was conducted to evaluate the protective effect of Naringin (NAR) on H9C2 cardiomyocytes in hypoxia/reoxygenation (HR) injury in vitro induced by the hypoxia chamber. Methods: H9C2 cells were grown under normal (control) and HR conditions. The viability, cardiolipin content and mitochondrial membrane potential of H9C2 cells in experimental groups were analyzed by using suitable kits. Results: The obtained results showed that the addition of Naringin (16÷160 µM) significantly increased the survival rate of H9C2 cells under HR conditions. In particular, NAR had the highest efficiency in preserving mitochondrial function at concentrations of 80 µM and 160 µM. In HR-exposed H9C2 cell group, the cardiolipin content and mitochondrial membrane potential values of H9C2 cells were decreased sharply with that of control (71,64±1,37% and 68,12±2,78%, p<0,05). Interestingly, mitochondrial cardiolipin contents were signigicantly increased in H9C2 cells post-hypoxic treated wtih NAR at dose of 80 µM 160 µM to 87,76±1,89% and 81,09±1,21%. Additionally, post-hypoxic supplementation of NAR at concentration of 80 µM and 160 µM effectively increased mitochondrial membrane potential values. Conclusion: The obtained results are preliminary data on the effects of NAR in protecting mitochondrial-targeted cardiomyocytes against HR injury.


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