Faculty Opinions recommendation of Systematic discovery of nonobvious human disease models through orthologous phenotypes.

2010 ◽  
Author(s):  
Ian Dunham
Keyword(s):  
Human Disease ◽  
Disease Models

The mouse ascending: perspectives for human-disease models

2007 ◽  
Vol 9 (9) ◽  
pp. 993-999 ◽  
Author(s):  
Nadia Rosenthal ◽  
Steve Brown
Keyword(s):  
Human Disease ◽  
Disease Models

Application of genome editing technologies in rats for human disease models

2017 ◽  
Vol 63 (2) ◽  
pp. 115-123 ◽  
Author(s):  
Kazuto Yoshimi ◽  
Tomoji Mashimo
Keyword(s):  
Genome Editing ◽  
Human Disease ◽  
Disease Models

scholarly journals The Zebrafish Model Organism Database: new support for human disease models, mutation details, gene expression phenotypes and searching

2016 ◽  
Vol 45 (D1) ◽  
pp. D758-D768 ◽  
Author(s):  
Douglas G. Howe ◽  
Yvonne M. Bradford ◽  
Anne Eagle ◽  
David Fashena ◽  
Ken Frazer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Disease ◽  
Model Organism ◽  
Disease Models ◽  
Model Organism Database ◽  
Zebrafish Model

scholarly journals RABBIT BIOMODELS OF HUMAN DISEASES DEVELOPED USING NEW GENOMIC TECHNOLOGIES. CRISPR/CAS9 (REVIEW)

Biomeditsina ◽  
2019 ◽  
pp. 12-33
Author(s):  
E. M. Koloskova ◽  
V. N. Karkischenko ◽  
V. A. Yezersky ◽  
N. V. Petrova ◽  
S. V. Maksimenko ◽  
...  
Keyword(s):  
Genome Editing ◽  
Human Disease ◽  
Genetically Modified ◽  
Human Diseases ◽  
Present Review ◽  
Disease Models ◽  
Genomic Technologies ◽  
Highly Effective ◽  
The Creation

With the advent of endonuclease methods of genome editing, particularly CRISPR/Cas9, it has become possible to obtain genetically modified rabbits by microinjection of zygotes. These highly effective human disease models can be used for various purposes. The present review aims to consider modern achievements in the creation of rabbit biomodels of human diseases using the technologies of genetic editing. It is concluded that Russian laboratories should intensify research in the development of genetically modified rabbits that can be used for various biomedical studies and biomodelling.

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