Faculty Opinions recommendation of A voltage-gated sodium channel is essential for the positive selection of CD4(+) T cells.

2012 ◽  
Author(s):  
Nick Gascoigne ◽  
Guo Fu
Keyword(s):  
T Cells ◽  
Sodium Channel ◽  
Positive Selection ◽  
Cd4 T Cells ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
Selection Of

scholarly journals A voltage-gated sodium channel is essential for the positive selection of CD4+ T cells

2012 ◽  
Vol 13 (9) ◽  
pp. 880-887 ◽  
Author(s):  
Wan-Lin Lo ◽  
David L Donermeyer ◽  
Paul M Allen
Keyword(s):  
T Cells ◽  
Sodium Channel ◽  
Positive Selection ◽  
Cd4 T Cells ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
Selection Of

Preferential expression of Vβ6.7 domain on human peripheral CD4+ T cells. Implication for positive selection of T cells in man

1991 ◽  
Vol 21 (6) ◽  
pp. 1571-1574 ◽  
Author(s):  
Andrea Cossarizza ◽  
Melvyn Kahan ◽  
Claudio Ortolani ◽  
Claudio Franceschi ◽  
Marco Londei
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Cd4 T Cells ◽  
Preferential Expression ◽  
Selection Of

scholarly journals Positive Selection of Cd4+ T Cells Is Induced in Vivo by Agonist and Inhibited by Antagonist Peptides

2001 ◽  
Vol 194 (4) ◽  
pp. 407-416 ◽  
Author(s):  
Piotr Kraj ◽  
Rafal Pacholczyk ◽  
Hanna Ignatowicz ◽  
Pawel Kisielow ◽  
Peter Jensen ◽  
...  
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Cd4 T Cells ◽  
In Vivo Model ◽  
Agonist Peptide ◽  
Histocompatibility Complex ◽  
Antagonist Peptides ◽  
Prevailing View ◽  
Selection Of

The nature of peptides that positively select T cells in the thymus remains poorly defined. Here we report an in vivo model to study the mechanisms of positive selection of CD4+ T cells. We have restored positive selection of TCR transgenic CD4+ thymocytes, arrested at the CD4+CD8+ stage, due to the lack of the endogenously selecting peptide(s), in mice deficient for H2-M and invariant chain. A single injection of soluble agonist peptide(s) initiated positive selection of CD4+ transgenic T cells that lasted for up to 14 days. Positively selected CD4+ T cells repopulated peripheral lymphoid organs and could respond to the antigenic peptide. Furthermore, coinjection of the antagonist peptide significantly inhibited agonist-driven positive selection. Hence, contrary to the prevailing view, positive selection of CD4+ thymocytes can be induced in vivo by agonist peptides and may be a result of accumulation of signals from TCR engaged by different peptides bound to major histocompatibility complex class II molecules. We have also identified a candidate natural agonist peptide that induces positive selection of CD4+ TCR transgenic thymocytes.

scholarly journals Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells.

1989 ◽  
Vol 170 (1) ◽  
pp. 135-143 ◽  
Author(s):  
N S Liao ◽  
J Maltzman ◽  
D H Raulet
Keyword(s):  
T Cells ◽  
T Cell ◽  
Positive Selection ◽  
T Cell Receptor ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Cell Receptor ◽  
Radiation Chimeras ◽  
Gene Usage ◽  
Selection Of

We report here a mAb, 14-2, reactive with TCRs that include V beta 14. The frequency of V beta 14+ T cells varies with CD4 and CD8 subset and is controlled by the H-2 genes. Thus CD8+ T cells from H-2b mice include approximately 2.3% V beta 14+ T cells while CD8+ T cells from mice expressing K kappa include greater than 8% V beta 14+ T cells. In all strains examined, 7-8% of CD4+ T cells express V beta 14. The frequent usage of V beta 14 in CD8+ T cells of K kappa-expressing mice is a result of preferential positive selection of V beta 14+ CD8+ T cells as demonstrated by analysis of radiation chimeras. These studies demonstrate that H-2-dependent positive selection occurs in unmanipulated mice. Furthermore, the results imply that positive selection, and possibly H-2 restriction, can be strongly influenced by a V beta domain, with some independence from the beta-junctional sequence and alpha chain.

Positive selection of CD4+T cells by TCR ligation without aggregation even in the absence of MHC

Nature ◽  
1994 ◽  
Vol 371 (6492) ◽  
pp. 67-70 ◽  
Author(s):  
Yousuke Takahama ◽  
Harumi Suzuki ◽  
Kenneth S. Katz ◽  
Michael J. Grusby ◽  
Alfred Singer
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Cd4 T Cells ◽  
Selection Of

scholarly journals Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides

Immunity ◽  
1997 ◽  
Vol 7 (2) ◽  
pp. 197-208 ◽  
Author(s):  
Catherine E Grubin ◽  
Susan Kovats ◽  
Paul deRoos ◽  
Alexander Y Rudensky
Keyword(s):  
T Cells ◽  
Positive Selection ◽  
Mhc Class Ii ◽  
Cd4 T Cells ◽  
Class Ii ◽  
Self Peptides ◽  
Selection Of
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