Faculty Opinions recommendation of Effect of different dosages of oral vitamin D supplementation on vitamin D status in healthy, breastfed infants: a randomized trial.

AbstractObjectiveTo examine the vitamin D status, SNP of the vitamin D receptor gene (VDR) and the effects of vitamin D supplementation on parathyroid hormone and insulin secretion in adult males with obesity or normal weight in a subtropical Chinese city.DesignAn intervention trial.SettingShenzhen City, Guangdong Province, China.SubjectsFrom a cross-sectional survey conducted from June to July, eighty-two normal-weight and ninety-nine obese males (18–69 years) were screened to analyse their vitamin D status and for five SNP of VDR. From these individuals, in the same season of a different year, obese and normal-weight male volunteers (twenty-one per group) were included for an intervention trial with oral vitamin D supplementation at 1250 µg/week for 8 weeks.ResultsFor the survey, there was no significant difference (P>0·05) in baseline circulating 25-hydroxyvitamin D concentrations or in the percentages of participants in different categories of vitamin D status between the two groups. The VDR SNP, rs3782905, was significantly associated with obesity (P=0·043), but none of the examined SNP were correlated with serum 25-hydroxyvitamin D when adjusted for age, BMI and study group. After vitamin D supplementation, serum 25-hydroxyvitamin D concentration, hypersecretions of parathyroid hormone and insulin, and insulin resistance in the obese were changed beneficially (P<0·05); however, the increase in serum 25-hydroxyvitamin D was less than that of the normal-weight men.ConclusionsFor obese and normal-weight men of subtropical China, the summer baseline vitamin D status was similar. However, oral vitamin D supplementation revealed a decreased bioavailability of vitamin D in obese men and ameliorated their hypersecretion of parathyroid hormone and insulin resistance.

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Circulating 25-Hydroxyvitamin D Levels in Fully Breastfed Infants on Oral Vitamin D Supplementation

International Journal of Endocrinology ◽

10.1155/2010/235035 ◽

2010 ◽

Vol 2010 ◽

pp. 1-5 ◽

Cited By ~ 22

Author(s):

Carol L. Wagner ◽

Cindy Howard ◽

Thomas C. Hulsey ◽

Ruth A. Lawrence ◽

Sarah N. Taylor ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Supplementation ◽

Vitamin Supplementation ◽

Oral Vitamin ◽

Oil Emulsion ◽

Hydroxyvitamin D ◽

Breastfed Infants ◽

25 Hydroxyvitamin D ◽

The Mean ◽

Nutritional Vitamin

Objective. To examine the effectiveness of oral vitamin (400 IU) supplementation on the nutritional vitamin D status of breastfeeding infants.Design. As part of a larger ongoing vitamin D RCT trial of lactating women, infants of mothers assigned to control received 1 drop of 400 IU vitamin /day starting at one month of age. Infant 25(OH)D levels (mean S.D.) were measured by RIA at visits 1, 4, and 7.Results. The infant mean S.D. 25(OH)D at baseline was 16.0 9.3 ng/mL (range 1.0–40.8; ); 24 (72.7%) had baseline levels <20 ng/mL (consistent with deficiency). The mean levels increased to 43.6 14.1 (range 18.2–69.7) at 4 months and remained relatively unchanged at month 7: 42.5 12.1 ng/mL (range 18.9–67.2). The change in values between 1 and 4 months and 1 and 7 months was statistically significant , and despite a decrease in dose per kilogram, values were not significantly different between months 4 and 7 .Conclusions. Oral vitamin supplementation as an oil emulsion was associated with significant and sustained increases in 25(OH)D from baseline in fully breastfeeding infants through 7 months.

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Vitamin D status in full-term exclusively breastfed infants versus full-term breastfed infants receiving vitamin D supplementation in Thailand: a randomized controlled trial

BMC Pediatrics ◽

10.1186/s12887-021-02849-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Chayatat Ruangkit ◽

Sukrit Suwannachat ◽

Pornchanok Wantanakorn ◽

Napapailin Sethaphanich ◽

Surapat Assawawiroonhakarn ◽

...

Keyword(s):

Vitamin D ◽

Growth Parameters ◽

Intervention Group ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Full Term ◽

Control Group ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Breastfed Infants

Abstract Background Many international medical organizations recommend vitamin D supplementation for infants, especially exclusively breastfed infants. In Thailand, however, data regarding the vitamin D status in Thai infants are lacking. Such data would help to support physician decisions and guide medical practice. Methods Full-term, exclusively breastfed infants were randomized into two groups at 2 months of age to continue exclusive breastfeeding either without vitamin D supplementation (control group, n = 44) or with vitamin D3 supplementation at 400 IU/day (intervention group, n = 43) until 6 months of age. At 6 months, the serum vitamin D (25OHD) of the infants and their mothers, serum bone marker, and infants’ growth parameters were compared between the two groups. Results The infants’ serum 25OHD concentration was lower in the control group than intervention group (20.57 ± 12.66 vs. 46.01 ± 16.42 ng/mL, p < 0.01). More infants had vitamin D sufficiency (25OHD of > 20 ng/mL) in the intervention group than control group (93.0% vs. 43.2%, p < 0.01). There were no significant differences in the maternal 25OHD concentrations between the control and intervention groups (25.08 ± 7.75 vs. 23.75 ± 7.64 ng/mL, p = 0.42). Serum calcium, phosphorus, intact parathyroid hormone, alkaline phosphatase, and infants’ growth parameters were comparable between the two groups. After adjustment for the confounding factors, 25OHD concentration in the intervention group was 25.66 ng/mL higher than the control group (95% confidence interval, 19.07–32.25; p < 0.001). Vitamin D supplement contributed to an 88.7% decrease in the prevalence of vitamin D insufficiency/deficiency (relative risk, 0.11; 95% confidence interval, 0.04–0.35; p < 0.01). Conclusions Most full-term, exclusively breastfed Thai infants have serum vitamin D concentration below sufficiency level at 6 months of age. However, vitamin D supplementation (400 IU/day) improves their vitamin D status and prevents vitamin D deficiency. Trial registration The study was pre-registered in the Thai Clinical Trials Registry (TCTR20190622001) on 22/06/2019.

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The effect of UV-B and oral vitamin D supplementation on the vitamin D status and PTH secretion in elderly nursing home patients

Osteoporosis International ◽

10.1007/bf02500542 ◽

1996 ◽

Vol 6 (S1) ◽

pp. 251-251 ◽

Cited By ~ 1

Author(s):

V G M Chel ◽

M E Ooms ◽

C Popp-Snijders ◽

A A Schothorst ◽

H Pavel ◽

...

Keyword(s):

Vitamin D ◽

Nursing Home ◽

Vitamin D Supplementation ◽

Vitamin D Status ◽

Oral Vitamin ◽

Nursing Home Patients

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Effect of combined maternal and infant vitamin D supplementation on vitamin D status of exclusively breastfed infants

Maternal and Child Nutrition ◽

10.1111/j.1740-8709.2008.00145.x ◽

2009 ◽

Vol 5 (1) ◽

pp. 25-32 ◽

Cited By ~ 40

Author(s):

Hussein F. Saadi ◽

Adekunle Dawodu ◽

Bachar Afandi ◽

Reem Zayed ◽

Sheela Benedict ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Supplementation ◽

Vitamin D Status ◽

Breastfed Infants

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Vitamin D Status in Full-term Exclusively Breastfed Infants versus Full-term Breastfed Infants Receiving Vitamin D Supplementation in Thailand: A Randomized Controlled Trial

10.21203/rs.3.rs-332758/v1 ◽

2021 ◽

Author(s):

Chayatat Ruangkit ◽

Sukrit Suwannachat ◽

Pornchanok Wantanakorn ◽

Napapailin Sethaphanich ◽

Surapat Assawawiroonhakarn ◽

...

Keyword(s):

Vitamin D ◽

Intervention Group ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Full Term ◽

Control Group ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Breastfed Infants ◽

25Ohd Concentration

Abstract Background: Many international medical organizations recommend vitamin D supplementation for infants, especially exclusively breastfed infants. In Thailand, however, data regarding the vitamin D status in Thai infants are lacking. Such data would help to support physician decisions and guide medical practice. Methods: Full-term, exclusively breastfed infants were randomized into two groups at 2 months of age to continue exclusive breastfeeding either without vitamin D supplementation (control group, n = 44) or with vitamin D3 supplementation at 400 IU/day (intervention group, n = 43) until 6 months of age. At 6 months, the serum vitamin D (25OHD) of the infants and their mothers, serum bone marker, and infants' growth parameters were compared between the two groups. Results: The infants' serum 25OHD concentration was lower in the control group than intervention group (20.57 ± 12.66 vs. 46.01 ± 16.42 ng/mL, p < 0.01). More infants had vitamin D sufficiency (25OHD of >20 ng/mL) in the intervention group than control group (93.0% vs. 43.2%, p < 0.01). Vitamin D supplementation in breastfed infants increased the mean serum 25OHD concentration by 25.66 ng/mL (95% confidence interval, 19.07–32.25; p < 0.001) and contributed to an 88.7% decrease in the prevalence of vitamin D insufficiency/deficiency (relative risk, 0.11; 95% confidence interval, 0.04–0.35; p < 0.01).Conclusions: Most full-term, exclusively breastfed Thai infants have serum vitamin D concentration below sufficiency level at 6 months of age. However, vitamin D supplementation (400 IU/day) improves their vitamin D status and prevents vitamin D deficiency.Trial registration: The study was pre-registered in the Thai Clinical Trials Registry (TCTR20190622001) on 22/06/2019.

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