Faculty Opinions recommendation of Noncoding RNA transcription targets AID to divergently transcribed loci in B cells.

2014 ◽  
Author(s):  
Petya Dimitrova ◽  
Velizar Shivarov
Keyword(s):  
B Cells ◽  
Noncoding Rna ◽  
Rna Transcription

scholarly journals Noncoding RNA transcription targets AID to divergently transcribed loci in B cells

Nature ◽  
2014 ◽  
Vol 514 (7522) ◽  
pp. 389-393 ◽  
Author(s):  
Evangelos Pefanis ◽  
Jiguang Wang ◽  
Gerson Rothschild ◽  
Junghyun Lim ◽  
Jaime Chao ◽  
...  
Keyword(s):  
B Cells ◽  
Noncoding Rna ◽  
Rna Transcription

scholarly journals Pervasive transcription-dependent chromatin remodeling influences the replication initiation program

2018 ◽  
Author(s):  
Julien Soudet ◽  
Jatinder Kaur ◽  
Françoise Stutz
Keyword(s):  
Chromatin Remodeling ◽  
Noncoding Rna ◽  
Transcription Termination ◽  
Replication Timing ◽  
Replication Initiation ◽  
Late Replication ◽  
H3k36 Methylation ◽  
Rna Transcription ◽  
Eukaryotic Organisms ◽  
Pervasive Transcription

ABSTRACTIn Eukaryotic organisms, replication initiation follows a temporal program. Among the parameters that regulate this program in Saccharomyces cerevisiae, chromatin structure has been at the center of attention without considering the contribution of transcription. Here, we revisit the replication initiation program in the light of pervasive transcription. We find that noncoding RNA transcription termination in the vicinity of replication origins or ARS (Autonomously Replicating Sequences) maximizes replication initiation by restricting transcriptional readthrough into ARS. Consistently, high natural nascent transcription correlates with low ARS efficiency and late replication timing. High readthrough transcription is also linked to chromatin features such as high levels of H3K36me3 and deacetylated nucleosomes. Moreover, forcing ARS readthrough transcription promotes these histone modifications. Finally, replication initiation defects induced by increased transcriptional readthrough are partially rescued in the absence of H3K36 methylation. Altogether, these observations indicate that natural pervasive transcription into ARS influences replication initiation through chromatin remodeling.

scholarly journals Noncoding RNA transcription at enhancers and genome folding in cancer

2019 ◽  
Vol 110 (8) ◽  
pp. 2328-2336 ◽  
Author(s):  
Takeshi Isoda ◽  
Tomohiro Morio ◽  
Masatoshi Takagi
Keyword(s):  
Noncoding Rna ◽  
Rna Transcription

Noncoding RNA transcription beyond annotated genes

2007 ◽  
Vol 17 (2) ◽  
pp. 139-144 ◽  
Author(s):  
Piero Carninci ◽  
Yoshihide Hayashizaki
Keyword(s):  
Noncoding Rna ◽  
Rna Transcription

scholarly journals The LPS-Induced Transcriptional Upregulation of the Chicken Lysozyme Locus Involves CTCF Eviction and Noncoding RNA Transcription

2008 ◽  
Vol 32 (1) ◽  
pp. 129-139 ◽  
Author(s):  
Pascal Lefevre ◽  
James Witham ◽  
Claire E. Lacroix ◽  
Peter N. Cockerill ◽  
Constanze Bonifer
Keyword(s):  
Noncoding Rna ◽  
Rna Transcription ◽  
Chicken Lysozyme

Inefficient splicing curbs noncoding RNA transcription

2021 ◽  
Vol 28 (4) ◽  
pp. 327-328
Author(s):  
Noa Gil ◽  
Igor Ulitsky
Keyword(s):  
Noncoding Rna ◽  
Rna Transcription

scholarly journals Regulation of B-cell growth and immunoglobulin gene transcription by interleukin-6

Blood ◽  
1992 ◽  
Vol 79 (2) ◽  
pp. 452-459 ◽  
Author(s):  
JE Tanner ◽  
G Tosato
Keyword(s):  
B Cells ◽  
B Cell ◽  
Interleukin 6 ◽  
Cell Activation ◽  
Cell Number ◽  
Immunoglobulin Gene ◽  
Rna Transcription ◽  
Barr Virus ◽  
Dna And Rna ◽  
Cycle Dependent

Interleukin-6 (IL-6) stimulates growth and immunoglobulin (lg) secretion in Epstein-Barr virus (EBV)-infected B cells. In this study, we demonstrate that B-cell activation by IL-6 is associated with an initial induction of c-myc, a gene believed to act as a competence factor for increased RNA transcription and DNA replication, and by increases in DNA, RNA, and protein synthesis, as well as cell number. IL-6 increased the levels of lg mRNA per cell in comparison to a non- cycle-dependent cellular mRNA, tubulin. However, two other cell cycle- dependent cellular mRNAs, c-myc and actin, were also induced by IL-6 comparable to lg mRNAs. Increased levels of lg mRNA were not due to significant changes in RNA turnover, but appeared to reflect increased levels of RNA transcription. Together, these findings support the notion that IL-6 plays an important role as a stimulator of DNA and RNA synthesis in EBV-activated B cells.

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