Faculty Opinions recommendation of Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome.

2015 ◽  
Author(s):  
Mark J Millan
Keyword(s):  
Down Syndrome ◽  
Synaptic Plasticity ◽  
Mouse Model

scholarly journals Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome

2017 ◽  
Vol 103 ◽  
pp. 1-10 ◽  
Author(s):  
Alexander M. Kleschevnikov ◽  
Jessica Yu ◽  
Jeesun Kim ◽  
Larisa V. Lysenko ◽  
Zheng Zeng ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Synaptic Plasticity ◽  
Mouse Model ◽  
Dentate Gyrus ◽  
Ts65dn Mouse ◽  
Gene Dose

scholarly journals Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome

2006 ◽  
Vol 99 (4) ◽  
pp. 1320-1320 ◽  
Author(s):  
Richard J. Siarey ◽  
Angelina Kline-Burgess ◽  
Madelaine Cho ◽  
Andrea Balbo ◽  
Tyler K. Best ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Synaptic Plasticity ◽  
Mouse Model ◽  
Signaling Pathways ◽  
Ts65dn Mouse ◽  
Hippocampal Synaptic Plasticity

Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down Syndrome

2014 ◽  
Vol 63 ◽  
pp. 12-19 ◽  
Author(s):  
Tatjana Begenisic ◽  
Laura Baroncelli ◽  
Gabriele Sansevero ◽  
Marco Milanese ◽  
Tiziana Bonifacino ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Synaptic Plasticity ◽  
Mouse Model ◽  
Spatial Memory ◽  
Gaba Release ◽  
Hippocampal Synaptic Plasticity

scholarly journals Deficits in Cognition and Synaptic Plasticity in a Mouse Model of Down Syndrome Ameliorated by GABAB Receptor Antagonists

2012 ◽  
Vol 32 (27) ◽  
pp. 9217-9227 ◽  
Author(s):  
A. M. Kleschevnikov ◽  
P. V. Belichenko ◽  
M. Faizi ◽  
L. F. Jacobs ◽  
K. Htun ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Synaptic Plasticity ◽  
Mouse Model ◽  
Gabab Receptor ◽  
Receptor Antagonists ◽  
Gabab Receptor Antagonists

Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome

2005 ◽  
Vol 49 (1) ◽  
pp. 122-128 ◽  
Author(s):  
Richard J. Siarey ◽  
Angela J. Villar ◽  
Charles J. Epstein ◽  
Zygmunt Galdzicki
Keyword(s):  
Down Syndrome ◽  
Synaptic Plasticity ◽  
Mouse Model ◽  
Trisomy 16

Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome

2015 ◽  
Vol 21 (4) ◽  
pp. 318-326 ◽  
Author(s):  
Gabriele Deidda ◽  
Martina Parrini ◽  
Shovan Naskar ◽  
Ignacio F Bozarth ◽  
Andrea Contestabile ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Synaptic Plasticity ◽  
Mouse Model

scholarly journals Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome

2008 ◽  
Vol 15 (7) ◽  
pp. 492-500 ◽  
Author(s):  
E. Morice ◽  
L. C. Andreae ◽  
S. F. Cooke ◽  
L. Vanes ◽  
E. M.C. Fisher ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Synaptic Plasticity ◽  
Mouse Model ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory

scholarly journals Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome

2006 ◽  
Vol 98 (4) ◽  
pp. 1266-1277 ◽  
Author(s):  
Richard J. Siarey ◽  
Angelina Kline-Burgess ◽  
Madelaine Cho ◽  
Andrea Balbo ◽  
Tyler K. Best ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Synaptic Plasticity ◽  
Mouse Model ◽  
Signaling Pathways ◽  
Ts65dn Mouse ◽  
Hippocampal Synaptic Plasticity
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