Faculty Opinions recommendation of Ultrastructural analysis of blood-brain barrier breakdown in the peri-infarct zone in young adult and aged mice.

2015 ◽  
Author(s):  
Jaime Grutzendler ◽  
Katie Murray
Keyword(s):  
Young Adult ◽  
Blood Brain Barrier ◽  
Ultrastructural Analysis ◽  
Brain Barrier ◽  
Infarct Zone ◽  
Aged Mice ◽  
Blood Brain ◽  
Barrier Breakdown ◽  
Blood Brain Barrier Breakdown

scholarly journals Ultrastructural analysis of blood–brain barrier breakdown in the peri-infarct zone in young adult and aged mice

2015 ◽  
Vol 36 (2) ◽  
pp. 413-425 ◽  
Author(s):  
Patrick C Nahirney ◽  
Patrick Reeson ◽  
Craig E Brown
Keyword(s):  
Young Adult ◽  
Basement Membrane ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Infarct Zone ◽  
Barrier Permeability ◽  
Blood Brain Barrier Permeability ◽  
Aged Mice ◽  
Blood Brain ◽  
Brain Barrier Permeability

Following ischemia, the blood–brain barrier is compromised in the peri-infarct zone leading to secondary injury and dysfunction that can limit recovery. Currently, it is uncertain what structural changes could account for blood–brain barrier permeability, particularly with aging. Here we examined the ultrastructure of early and delayed changes (3 versus 72 h) to the blood–brain barrier in young adult and aged mice (3–4 versus 18 months) subjected to photothrombotic stroke. At both time points and ages, permeability was associated with a striking increase in endothelial caveolae and vacuoles. Tight junctions were generally intact although small spaces were detected in a few cases. In young mice, ischemia led to a significant increase in pericyte process area and vessel coverage whereas these changes were attenuated with aging. Stroke led to an expansion of the basement membrane region that peaked at 3 h and partially recovered by 72 h in both age groups. Astrocyte endfeet and their mitochondria were severely swollen at both times points and ages. Our results suggest that blood–brain barrier permeability in young and aged animals is mediated by transcellular pathways (caveolae/vacuoles), rather than tight junction loss. Further, our data indicate that the effects of ischemia on pericytes and basement membrane are affected by aging.

scholarly journals Evidences of endocytosis via caveolae following blood–brain barrier breakdown by Phoneutria nigriventer spider venom

2014 ◽  
Vol 229 (3) ◽  
pp. 415-422 ◽  
Author(s):  
Edilene Siqueira Soares ◽  
Monique Culturato Padilha Mendonça ◽  
Silvia Pierre Irazusta ◽  
Andressa Coope ◽  
Leila Miguel Stávale ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Spider Venom ◽  
Blood Brain ◽  
Barrier Breakdown ◽  
Blood Brain Barrier Breakdown ◽  
Phoneutria Nigriventer

Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults

2018 ◽  
Vol 14 (12) ◽  
pp. 1640-1650 ◽  
Author(s):  
Gene L. Bowman ◽  
Loïc Dayon ◽  
Richard Kirkland ◽  
Jérôme Wojcik ◽  
Gwendoline Peyratout ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Barrier Breakdown ◽  
Blood Brain Barrier Breakdown
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