Faculty Opinions recommendation of Estimation of the exposure of the UK population to the bovine spongiform encephalopathy agent through dietary intake during the period 1980 to 1996.

2017 ◽  
Author(s):  
Robert Will ◽  
Graeme Mackenzie
Keyword(s):  
Dietary Intake ◽  
Bovine Spongiform Encephalopathy ◽  
Spongiform Encephalopathy ◽  
The Uk ◽  
Bovine Spongiform Encephalopathy Agent

scholarly journals Oral Transmission of L-Type Bovine Spongiform Encephalopathy Agent among Cattle

2017 ◽  
Vol 23 (2) ◽  
pp. 284-287 ◽  
Author(s):  
Hiroyuki Okada ◽  
Yoshifumi Iwamaru ◽  
Morikazu Imamura ◽  
Kohtaro Miyazawa ◽  
Yuichi Matsuura ◽  
...  
Keyword(s):  
Bovine Spongiform Encephalopathy ◽  
Spongiform Encephalopathy ◽  
Oral Transmission ◽  
Bovine Spongiform Encephalopathy Agent

Evaluation of a Rapid Western Immunoblotting Procedure for the Diagnosis of Bovine Spongiform Encephalopathy (BSE) in the UK

2001 ◽  
Vol 125 (1) ◽  
pp. 64-70 ◽  
Author(s):  
W.A. Cooley ◽  
J.K. Clark ◽  
S.J. Ryder ◽  
L.A. Davis ◽  
S.S.J. Farrelly ◽  
...  
Keyword(s):  
Bovine Spongiform Encephalopathy ◽  
Spongiform Encephalopathy ◽  
Western Immunoblotting ◽  
The Uk

Bone marrow infectivity in cattle exposed to the bovine spongiform encephalopathy agent

2009 ◽  
Vol 164 (9) ◽  
pp. 272-274 ◽  
Author(s):  
H. J. Sohn ◽  
Y. H. Lee ◽  
R. B. Green ◽  
Y. I. Spencer ◽  
S. A. C. Hawkins ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bovine Spongiform Encephalopathy ◽  
Spongiform Encephalopathy ◽  
Bovine Spongiform Encephalopathy Agent

scholarly journals Complex proteinopathy with accumulations of prion protein, hyperphosphorylated tau, α-synuclein and ubiquitin in experimental bovine spongiform encephalopathy of monkeys

2014 ◽  
Vol 95 (7) ◽  
pp. 1612-1618 ◽  
Author(s):  
Pedro Piccardo ◽  
Juraj Cervenak ◽  
Ming Bu ◽  
Lindsay Miller ◽  
David M. Asher
Keyword(s):  
Neurodegenerative Diseases ◽  
Bovine Spongiform Encephalopathy ◽  
Prion Protein ◽  
Common Mechanism ◽  
Spongiform Encephalopathy ◽  
Hyperphosphorylated Tau ◽  
Jakob Disease ◽  
Spongiform Degeneration ◽  
Bovine Spongiform Encephalopathy Agent ◽  
Classical Bovine Spongiform Encephalopathy

Proteins aggregate in several slowly progressive neurodegenerative diseases called ‘proteinopathies’. Studies with cell cultures and transgenic mice overexpressing mutated proteins suggested that aggregates of one protein induced misfolding and aggregation of other proteins as well – a possible common mechanism for some neurodegenerative diseases. However, most proteinopathies are ‘sporadic’, without gene mutation or overexpression. Thus, proteinopathies in WT animals genetically close to humans might be informative. Squirrel monkeys infected with the classical bovine spongiform encephalopathy agent developed an encephalopathy resembling variant Creutzfeldt–Jakob disease with accumulations not only of abnormal prion protein (PrPTSE), but also three other proteins: hyperphosphorylated tau (p-tau), α-synuclein and ubiquitin; β-amyloid protein (Aβ) did not accumulate. Severity of brain lesions correlated with spongiform degeneration. No amyloid was detected. These results suggested that PrPTSE enhanced formation of p-tau and aggregation of α-synuclein and ubiquitin, but not Aβ, providing a new experimental model for neurodegenerative diseases associated with complex proteinopathies.

Proteolytic inactivation of the bovine spongiform encephalopathy agent

2004 ◽  
Vol 317 (4) ◽  
pp. 1165-1170 ◽  
Author(s):  
Anne H McLeod ◽  
Heather Murdoch ◽  
Jo Dickinson ◽  
Mike J Dennis ◽  
Graham A Hall ◽  
...  
Keyword(s):  
Bovine Spongiform Encephalopathy ◽  
Spongiform Encephalopathy ◽  
Bovine Spongiform Encephalopathy Agent

scholarly journals Enhanced Virulence of Sheep-Passaged Bovine Spongiform Encephalopathy Agent Is Revealed by Decreased Polymorphism Barriers in Prion Protein Conversion Studies

2013 ◽  
Vol 88 (5) ◽  
pp. 2903-2912 ◽  
Author(s):  
J. Priem ◽  
J. P. M. Langeveld ◽  
L. J. M. van Keulen ◽  
F. G. van Zijderveld ◽  
O. Andreoletti ◽  
...  
Keyword(s):  
Bovine Spongiform Encephalopathy ◽  
Prion Protein ◽  
Spongiform Encephalopathy ◽  
Bovine Spongiform Encephalopathy Agent
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