Faculty Opinions recommendation of Analyzing the human serum antibody responses to a live attenuated tetravalent dengue vaccine candidate.

2018 ◽  
Author(s):  
Scott Halstead
Keyword(s):  
Human Serum ◽  
Vaccine Candidate ◽  
Serum Antibody ◽  
Antibody Responses ◽  
Dengue Vaccine

scholarly journals Analyzing the Human Serum Antibody Responses to a Live Attenuated Tetravalent Dengue Vaccine Candidate

2018 ◽  
Vol 217 (12) ◽  
pp. 1932-1941 ◽  
Author(s):  
Jesica A Swanstrom ◽  
Sandra Henein ◽  
Jessica A Plante ◽  
Boyd L Yount ◽  
Douglas G Widman ◽  
...  
Keyword(s):  
Human Serum ◽  
Vaccine Candidate ◽  
Serum Antibody ◽  
Antibody Responses ◽  
Dengue Vaccine

Human serum antibody responses to oral microorganisms IV. Correlation with homologous infection

1987 ◽  
Vol 2 (2) ◽  
pp. 53-59 ◽  
Author(s):  
J. L. Ebersole ◽  
M. A. Taubman ◽  
D. J. Smith ◽  
D. E. Frey ◽  
A. D. Haffajee ◽  
...  
Keyword(s):  
Human Serum ◽  
Serum Antibody ◽  
Antibody Responses ◽  
Oral Microorganisms

scholarly journals Profiles of Human Serum Antibody Responses Elicited by Three Leading HIV Vaccines Focusing on the Induction of Env-Specific Antibodies

PLoS ONE ◽  
2010 ◽  
Vol 5 (11) ◽  
pp. e13916 ◽  
Author(s):  
Michael Vaine ◽  
Shixia Wang ◽  
Qin Liu ◽  
James Arthos ◽  
David Montefiori ◽  
...  
Keyword(s):  
Human Serum ◽  
Serum Antibody ◽  
Antibody Responses ◽  
Hiv Vaccines ◽  
Specific Antibodies

scholarly journals Long-term human serum antibody responses after immunization with whole-cell pertussis vaccine in France.

1996 ◽  
Vol 3 (1) ◽  
pp. 93-97 ◽  
Author(s):  
E Grimprel ◽  
P Bégué ◽  
I Anjak ◽  
E Njamkepo ◽  
P François ◽  
...  
Keyword(s):  
Human Serum ◽  
Pertussis Vaccine ◽  
Serum Antibody ◽  
Antibody Responses ◽  
Whole Cell

scholarly journals Development of a novel assay to assess the avidity of dengue virus-specific antibodies elicited in response to a tetravalent dengue vaccine

2021 ◽  
Author(s):  
Isamu Tsuji ◽  
David Dominguez ◽  
Michael A Egan ◽  
Hansi J Dean
Keyword(s):  
Dengue Virus ◽  
Neutralizing Antibodies ◽  
Serum Antibody ◽  
Neutralizing Antibody ◽  
Affinity Maturation ◽  
Antibody Responses ◽  
Antibody Affinity ◽  
Dengue Vaccine ◽  
Avidity Index ◽  
Two Phase

Abstract Antibody affinity maturation is a critical step in development of functional antiviral immunity, however, accurate measurement of affinity maturation of polyclonal serum antibody responses to particulate antigens such as virions is challenging. We describe a novel avidity assay employing bio-layer interferometry and dengue virus-like particles. After validation using anti-dengue monoclonal antibodies, the assay was used to assess avidity of antibody responses to a tetravalent dengue vaccine candidate (TAK-003) in children, adolescents and adults during two Phase 2 clinical trials conducted in dengue endemic regions. Vaccination increased avidity index and avidity remained high through one-year post vaccination. Neutralizing antibody titers and avidity index did not correlate overall, however, a correlation was observed between neutralizing antibody titer and avidity index in those subjects with the highest degree of antibody affinity maturation. Therefore, vaccination with TAK-003 stimulates polyclonal affinity maturation and functional antibody responses including neutralizing antibodies.

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