Faculty Opinions recommendation of Enhancement of the chondrogenic differentiation of mesenchymal stem cells and cartilage repair by ghrelin.

2019 ◽  
Author(s):  
Ming Pei
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cartilage Repair ◽  
Chondrogenic Differentiation ◽  
And Cartilage

scholarly journals Enhancement of the chondrogenic differentiation of mesenchymal stem cells and cartilage repair by ghrelin

2019 ◽  
Vol 37 (6) ◽  
pp. 1387-1397 ◽  
Author(s):  
Litong Fan ◽  
Jiaqing Chen ◽  
Yanmeng Tao ◽  
Boon Chin Heng ◽  
Jiakuo Yu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cartilage Repair ◽  
Chondrogenic Differentiation ◽  
And Cartilage

Role of mesenchymal stem cells in regenerative medicine: application to bone and cartilage repair

2008 ◽  
Vol 8 (3) ◽  
pp. 255-268 ◽  
Author(s):  
Froilan Granero-Molto ◽  
Jared A Weis ◽  
Lara Longobardi ◽  
Anna Spagnoli
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Cartilage Repair ◽  
And Cartilage ◽  
Medicine Application

The Use of Mesenchymal Stem Cells for Bone and Cartilage Repair

2008 ◽  
pp. 269-294
Author(s):  
Rosemary Behan ◽  
Nagy A. Habib ◽  
Sean P. F. Hughes ◽  
Myrtle Y. Gordon ◽  
Nataša Levičar
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cartilage Repair ◽  
And Cartilage

Mesenchymal stem cells in bone and cartilage repair: current status

2006 ◽  
Vol 1 (4) ◽  
pp. 589-604 ◽  
Author(s):  
Jean-Thomas Vilquin ◽  
Philippe Rosset
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cartilage Repair ◽  
Current Status ◽  
And Cartilage

scholarly journals Articular chondrocyte derived exosomes promote cartilage differentiation of human umbilical cord mesenchymal stem cells by activation of autophagy

2020 ◽  
Author(s):  
Ke Ma ◽  
Bo Zhu ◽  
Zetao Wang ◽  
Peian Cai ◽  
Mingwei He ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Cartilage Repair ◽  
Chondrogenic Differentiation ◽  
Phenotypic Expression ◽  
Cartilage Regeneration ◽  
Human Umbilical Cord ◽  
Articular Chondrocyte

Abstract Background Umbilical cord mesenchymal stem cells (HUCMSCs)-based therapies were previously predicated in cartilage regeneration due to the chondrogenic potential of MSCs. However, chondrogenic differentiation of HUMSCs is limited by administration of growth factors like TGF-β that may cause cartilage hypertrophy. It has been reported the exosomes could modulate phenotypic expression of stem cells. However, the role of human chondrogenic derived exosomes (C-EXO) in chondrogenic differentiation of HUCMSCs has not been reported. Results In this study, we successfully isolated chondrocyte-derived exosomes (C-EXO) from human multi-finger cartilage and found that C-EXO efficiently promoted the proliferation and chondrogenic differentiation of HUCMSCs, evidenced by highly expressed aggrecan (ACAN), COL2A and SOX-9. Also, the expression of the fibrotic marker, COL1A and hypertrophic marker, COL10, was significantly lower than that induced by TGF-β. In vivo, stimulation of C-EXO accelerated HUCMSCs-mediated cartilage repair in rabbit models. Furthermore, C-EXO led to increasing autophagosomes during the process of chondrogenic differentiation, indicating that C-EXO promoted cartilage regeneration might be through the activation of autophagy. Conclusions This study suggests that C-EXO has an essential role in fostering chondrogenic differentiation and proliferation of HUCMSCs, which may be a stable supply for articular cartilage repair.

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