scholarly journals Faculty Opinions recommendation of Pregnancy rate in women with adenomyosis undergoing fresh or frozen embryo transfer cycles following gonadotropin-releasing hormone agonist treatment.

Author(s):  
Felice Petraglia ◽  
Silvia Vannuccini
2020 ◽  
Vol 48 (6) ◽  
pp. 030006052091847
Author(s):  
Qianrong Qi ◽  
Jin Luo ◽  
Yaqin Wang ◽  
Qingzhen Xie

Objective This study aimed to compare the pregnancy outcomes between women receiving frozen embryo transfer (FET) with hormone replacement treatment (HRT) with and without gonadotropin-releasing hormone agonist (GnRHa) pretreatment. Methods All consecutive women undergoing HRT cycles (2936 cycles) or HRT with GnRHa pretreatment (HRT + GnRHa, 303 cycles) at our reproductive center between January 2015 and December 2017 were analyzed retrospectively. Results The average age was higher in the HRT + GnRHa compared with the HRT group (34.0 ± 4.8 vs. 31.3 ± 4.4). However, the pregnancy outcomes were comparable between the two groups. The clinical pregnancy rate was significantly increased in younger women (≤35 years) in the HRT + GnRHa group compared with the HRT group (56.8% vs. 48.7%), but the live birth rates were similar in the two groups (44.2% vs. 38.4%). The HRT + GnRHa protocol significantly increased the clinical pregnancy rate (55.6% vs. 43.2%) and live birth rate (43.5% vs. 33.5%) compared with the HRT group among women with endometriosis, and significantly decreased the abortion rate in women with polycystic ovarian syndrome (3.1% vs. 16.4%). Conclusions GnRHa pretreatment may improve pregnancy outcomes in women with endometriosis and polycystic ovarian syndrome.


1991 ◽  
Vol 36 (6) ◽  
pp. 1035-1042 ◽  
Author(s):  
J.E. Ellington ◽  
R.H. Foote ◽  
P.B. Farrell ◽  
J.F. Hasler ◽  
J. Webb ◽  
...  

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