Faculty Opinions recommendation of Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance.

2020 ◽  
Author(s):  
Antony Galione ◽  
Anthony John Morgan
Keyword(s):  
Immune Surveillance ◽  
Ion Fluxes ◽  
Monovalent Ion ◽  
Endocytic Traffic

scholarly journals Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance

Science ◽  
2019 ◽  
Vol 367 (6475) ◽  
pp. 301-305 ◽  
Author(s):  
Spencer A. Freeman ◽  
Stefan Uderhardt ◽  
Amra Saric ◽  
Richard F. Collins ◽  
Catherine M. Buckley ◽  
...  
Keyword(s):  
Immune Surveillance ◽  
Extracellular Fluid ◽  
Volume Ratio ◽  
Underlying Mechanism ◽  
Endocytic Pathway ◽  
Curvature Sensing ◽  
Monovalent Ion ◽  
Endocytic Traffic

Despite ongoing (macro)pinocytosis of extracellular fluid, the volume of the endocytic pathway remains unchanged. To investigate the underlying mechanism, we used high-resolution video imaging to analyze the fate of macropinosomes formed by macrophages in vitro and in situ. Na+, the primary cationic osmolyte internalized, exited endocytic vacuoles via two-pore channels, accompanied by parallel efflux of Cl− and osmotically coupled water. The resulting shrinkage caused crenation of the membrane, which fostered recruitment of curvature-sensing proteins. These proteins stabilized tubules and promoted their elongation, driving vacuolar remodeling, receptor recycling, and resolution of the organelles. Failure to resolve internalized fluid impairs the tissue surveillance activity of resident macrophages. Thus, osmotically driven increases in the surface-to-volume ratio of endomembranes promote traffic between compartments and help to ensure tissue homeostasis.

Signalling mitogenesis in 3T3 cells: role of monovalent ion fluxes and cyclic nucleotides

1982 ◽  
Vol 2 (8) ◽  
pp. 589-595 ◽  
Author(s):  
Enrique Rozengurt ◽  
Nigel Courtenay-Luck
Keyword(s):  
Cyclic Nucleotides ◽  
Ion Fluxes ◽  
3T3 Cells ◽  
Monovalent Ion

scholarly journals Balance of unidirectional monovalent ion fluxes in cells undergoing apoptosis: why does Na+/K+pump suppression not cause cell swelling?

2011 ◽  
Vol 589 (9) ◽  
pp. 2197-2211 ◽  
Author(s):  
Valentina E. Yurinskaya ◽  
Andrey A. Rubashkin ◽  
Alexey A. Vereninov
Keyword(s):  
Ion Fluxes ◽  
Cell Swelling ◽  
Monovalent Ion ◽  
In Cells

From the inside out: Ion fluxes at the centre of endocytic traffic

2021 ◽  
Vol 71 ◽  
pp. 77-86
Author(s):  
Sarah R. Chadwick ◽  
Sergio Grinstein ◽  
Spencer A. Freeman
Keyword(s):  
Ion Fluxes ◽  
Endocytic Traffic ◽  
Inside Out
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