scholarly journals Faculty Opinions recommendation of Sensory neuron-derived NaV1.7 contributes to dorsal horn neuron excitability.

2020 ◽  
Author(s):  
Nikita Gamper
Keyword(s):  
Dorsal Horn ◽  
Sensory Neuron ◽  
Dorsal Horn Neuron ◽  
Neuron Excitability ◽  
Horn Neuron

Electrical stimulation of the primary somatosensory cortex inhibits spinal dorsal horn neuron activity

2005 ◽  
Vol 1057 (1-2) ◽  
pp. 134-140 ◽  
Author(s):  
Arun K. Senapati ◽  
Paula J. Huntington ◽  
Stacey C. LaGraize ◽  
Hilary D. Wilson ◽  
Perry N. Fuchs ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Somatosensory Cortex ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Dorsal Horn Neuron ◽  
Neuron Activity ◽  
Spinal Dorsal ◽  
Spinal Dorsal Horn Neuron ◽  
Horn Neuron ◽  
Stimulation Of

scholarly journals Sensory neuron–derived NaV1.7 contributes to dorsal horn neuron excitability

2020 ◽  
Vol 6 (8) ◽  
pp. eaax4568 ◽  
Author(s):  
Sascha R. A. Alles ◽  
Filipe Nascimento ◽  
Rafael Luján ◽  
Ana P. Luiz ◽  
Queensta Millet ◽  
...  
Keyword(s):  
Dorsal Horn ◽  
Dorsal Horn Neuron ◽  
Mutant Mice ◽  
Afferent Neuron ◽  
Null Mutant ◽  
Dorsal Horn Neurons ◽  
Afferent Nerves ◽  
Horn Neuron ◽  
Null Mutant Mice

Expression of the voltage-gated sodium channel NaV1.7 in sensory neurons is required for pain sensation. We examined the role of NaV1.7 in the dorsal horn of the spinal cord using an epitope-tagged NaV1.7 knock-in mouse. Immuno–electron microscopy showed the presence of NaV1.7 in dendrites of superficial dorsal horn neurons, despite the absence of mRNA. Rhizotomy of L5 afferent nerves lowered the levels of NaV1.7 in the dorsal horn. Peripheral nervous system–specific NaV1.7 null mutant mice showed central deficits, with lamina II dorsal horn tonic firing neurons more than halved and single spiking neurons more than doubled. NaV1.7 blocker PF05089771 diminished excitability in dorsal horn neurons but had no effect on NaV1.7 null mutant mice. These data demonstrate an unsuspected functional role of primary afferent neuron-generated NaV1.7 in dorsal horn neurons and an expression pattern that would not be predicted by transcriptomic analysis.

Dissection, Plating, and Maintenance of Dorsal Horn Neuron Cultures

2009 ◽  
Vol 2009 (8) ◽  
pp. pdb.prot5274-pdb.prot5274 ◽  
Author(s):  
C. Albuquerque ◽  
D. J. Joseph ◽  
P. Choudhury ◽  
A. B. MacDermott
Keyword(s):  
Dorsal Horn ◽  
Dorsal Horn Neuron ◽  
Horn Neuron

Primary afferent and sacral dorsal horn neuron responses to vaginal probing in the cat

1981 ◽  
Vol 26 (1) ◽  
pp. 67-72 ◽  
Author(s):  
Donald D. Price ◽  
M.Catherine Bushnell ◽  
Michael J. Iadarola
Keyword(s):  
Dorsal Horn ◽  
Dorsal Horn Neuron ◽  
Primary Afferent ◽  
Horn Neuron

Role of D-serine in superficial dorsal horn neuron

PAIN RESEARCH ◽  
2011 ◽  
Vol 26 (1) ◽  
pp. 19-28
Author(s):  
Yasuhiko Kawasaki ◽  
Terumasa Nakatsuka ◽  
Mika Sasaki ◽  
Fumimasa Amaya ◽  
Tatsuro Kohno
Keyword(s):  
Dorsal Horn ◽  
Dorsal Horn Neuron ◽  
Superficial Dorsal Horn ◽  
Horn Neuron
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