Inhibiting inflammasome; the possible mechanisms of action of azithromycin against COVID-19?

2021 ◽  
Vol 6 (1) ◽  
pp. e10-e10
Author(s):  
Ali Saeedi-Boroujeni ◽  
Mohammad Bahadoram ◽  
Bijan Keikhaei ◽  
Mohammad-Reza Mahmoudian-Sani ◽  
Azadeh Khayyat ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Distress Syndrome ◽  
Severe Case ◽  
Mechanisms Of Action ◽  
Severe Form ◽  
Cytokine Storm ◽  
Immunomodulatory Properties ◽  
Destructive Inflammation

Cytokine storm and destructive inflammation in the severe form of COVID-19 lead to acute respiratory distress syndrome (ARDS)/acute lung injury (ALI), and dysfunction of several different body organs in patients. SARS-CoV-2 contains all inflammasome-activating proteins belonging to SARS-CoV and MERS-CoV viruses. Macrolides are known to possess immunomodulatory properties. Given the desirable results of azithromycin treatment for patients with a severe case of COVID-19, based on studies, it could be concluded that the immunomodulatory properties of azithromycin to inhibit inflammasome can help the treatment of patients with this disease.

scholarly journals Acute lung injury and acute respiratory distress syndrome: What should we know?

2010 ◽  
Vol 57 (4) ◽  
pp. 25-32
Author(s):  
Vesna Bumbasirevic ◽  
Bojan Jovanovic ◽  
Djordje Bajec ◽  
Zaneta Terziski ◽  
Milena Pandurovic ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Lung Ventilation ◽  
Severe Form ◽  
Ventilation Strategy ◽  
Clinical Disorders

Acute lung injury(ALI)and its more severe form acute respiratory distress syndrome (ARDS) are syndromes with a spectrum of increasing severity of lung injury defined by physiologic and radiographic criteria. There are many clinical disorders associated with the development of ALI/ARDS and can be divided into those associated with direct or indirect lung injury. Early detection and protective lung ventilation strategy contribute to lowering the mortality rate.

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