UNUSUAL CASE OF ANAEMIA IN ADULT MALE

A case of Anaemia which was investigated and found to be a case of Acquired Pure Red Cell Aplasia. Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anaemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. It is commonly due to primary autoimmune or infection and secondary to myeloproliferative disorder. In this discussion we are presenting a case of normocytic normochromic anaemia which was admitted to our hospital after being investigated and treated several times outside. On extensive workup, we diagnosed the case as PRCA secondary to Thymoma and initiated the appropriate management.

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A case of parvovirus B19-induced pure red cell aplasia in a child following heart transplant

Cardiology in the Young ◽

10.1017/s1047951114000225 ◽

2014 ◽

Vol 25 (2) ◽

pp. 373-375 ◽

Cited By ~ 4

Author(s):

Eoin Kelleher ◽

Corrina McMahon ◽

Colin J. McMahon

Keyword(s):

Bone Marrow ◽

Heart Transplant ◽

Parvovirus B19 ◽

Pure Red Cell Aplasia ◽

Red Cell ◽

Orthotopic Heart Transplant ◽

Red Cell Aplasia ◽

Normocytic Normochromic Anaemia ◽

Immunosuppressed Patients ◽

Parvovirus B19 Infection

AbstractWe describe a case of an 11-year-old boy who underwent orthotopic heart transplant for dilated cardiomyopathy. He developed a normocytic, normochromic anaemia with a low reticulocyte count 1 month after transplant. A bone marrow biopsy was performed, which showed a mildly hypocellular bone marrow with few red blood cell precursors with giant pro-erythroblasts indicative of a pure red cell aplasia. Parvovirus B19 polymerase chain reaction in the blood was positive 2 months after transplant. Intravenous immunoglobulin administration resulted in a resolution of the anaemia over several months. Unexplained pure red cell aplasia in immunosuppressed patients should alert one to the possibility of parvovirus B19 infection.

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PURE RED CELL APLASIA : A CASE REPORT

10.36106/ijar/9702236 ◽

2021 ◽

pp. 55-56

Author(s):

G Srivani ◽

D Roja Aishwarya ◽

P. V. S. Kiran

Keyword(s):

Bone Marrow ◽

Bone Marrow Failure ◽

Bone Marrow Aspiration ◽

Oral Prednisolone ◽

Pure Red Cell Aplasia ◽

Red Cell ◽

Red Cell Aplasia ◽

Normocytic Normochromic Anemia ◽

Pure Cell ◽

Normochromic Anemia

Pure cell aplasia is a rare bone marrow failure that affects erythroid lineage characterized by normocytic normochromic anemia with reticulocytopenia in the peripheral blood and absent or infrequent erythroblasts in the bone marrow. It can be congenital or acquired. Acquired can be primary when no cause is identied or secondary-due to underlying or associated pathology. Herein we report a case of a 28 year old female with Primary Acquired Pure Red cell aplasia. The patient presented with severe anemia (Hb-1.9gm%) and low reticulocyte count 0.1%. Bone marrow aspiration shows normocellular marrow with Decreased erythropoiesis with M:E ratio of 20:1..Patient was started on oral prednisolone and improvement was seen and the patient became transfusion independent.

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Anemia: Production Defects Generally Associated with Marrow Aplasia or Replacement

10.2310/fm.1339 ◽

2017 ◽

Author(s):

Nancy Berliner ◽

John M Gansner

Keyword(s):

Bone Marrow ◽

Differential Diagnosis ◽

Aplastic Anemia ◽

Blood Smear ◽

Pure Red Cell Aplasia ◽

Red Cell ◽

Normal Bone Marrow ◽

Normal Bone ◽

Red Cell Aplasia

This review focuses on anemia resulting from production defects generally associated with marrow aplasia or replacement. The definition, epidemiology, etiology, pathogenesis, diagnosis, differential diagnosis, management, complications, and prognosis of the following production defects are discussed: Acquired aplastic anemia and acquired pure red cell aplasia. Figures depict a leukoerythroblastic blood smear, a biopsy comparing normal bone marrow and bone marrow showing almost complete aplasia, and a marrow smear. A table lists the causes of aplastic anemia. This review contains 3 figures; 1 table; 108 references.

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Recovery of erythropoiesis following allogeneic bone marrow transplantation for chronic lymphocytic leukaemia-associated pure red cell aplasia

Bone Marrow Transplantation ◽

10.1038/sj.bmt.1702992 ◽

2001 ◽

Vol 27 (7) ◽

pp. 771-773 ◽

Cited By ~ 3

Author(s):

MP de Vetten ◽

M van Gelder ◽

GE de Greef

Keyword(s):

Bone Marrow ◽

Bone Marrow Transplantation ◽

Chronic Lymphocytic Leukaemia ◽

Marrow Transplantation ◽

Lymphocytic Leukaemia ◽

Allogeneic Bone Marrow Transplantation ◽

Pure Red Cell Aplasia ◽

Allogeneic Bone ◽

Red Cell ◽

Red Cell Aplasia

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Immunophenotype of Erythroid Precursors in Patient with Pure Red Cell Aplasia (PRCA): Utility of Analysis of Erythroid Maturation

Annals of Hematology & Oncology ◽

10.26420/annhematoloncol.2021.1346 ◽

2021 ◽

Vol 8 (5) ◽

Author(s):

Jerez J ◽

◽

Ocqueteau M ◽

Keyword(s):

Correct Diagnosis ◽

Standard Of Care ◽

Pure Red Cell Aplasia ◽

Refractory Anemia ◽

Red Cell ◽

Red Cell Aplasia ◽

Bone Marrow Histology ◽

Erythroid Precursors ◽

Normochromic Anemia ◽

Erythroid Maturation

Pure Red Cell Aplasia (PRCA) is an infrequent disease [1,2], which usually presents as hypogenerative normochromic anemia, and is characterized by a significant decrease (including absence) of erythroid precursors [3]. Its etiology can be congenital or acquired, and its correct diagnosis requires exclusion of alternative cases of refractory anemia, so the bone marrow histology plays a crucial role. Myelodisplastic Syndromes (MDS) should always be considered in its differential diagnosis. The use of laboratory tools, specifically Flow Cytometry (FCM) is gained importance in the study of malignant and benign hematology pathologies. In MDS, FCM is not yet considered a standard of care, however it provides valuable information [4,5] and there are numerous publications and scores for its usual clinical use (for example Ogata score and RED-score [6,7]). In relation to the rise of FCM in MDS, enormous progress has been made in the description of the erythroid precursors immunophenotype [8-10]. An example of normal erythroid maturation is presented in Figure 1, showing proerythroblasts with immunophenotype CD71+ CD105+ CD117+, basophilic erythroblasts CD71+ CD105+ CD117-, polychromatophilic and orthochromatophilic erythroblasts CD71+ CD105- CD117- distinguishing by size in Forward Scatter (FSC) versus CD36 respectively. Characteristic maturation curve in CD117 versus CD105 analysis evidenced a predominance towards more mature erythroblasts.

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Pure red cell aplasia caused by Parvo B19 virus in a kidney transplant recipient

Journal of Nepal Medical Association ◽

10.31729/jnma.73 ◽

2012 ◽

Vol 52 (186) ◽

Cited By ~ 2

Author(s):

A Baral ◽

B Poudel ◽

R K Agrawal ◽

R Hada ◽

S Gurung

Keyword(s):

Bone Marrow ◽

Transplant Recipient ◽

Intravenous Immunoglobulin ◽

Kidney Transplant ◽

Parvovirus B19 ◽

Kidney Transplant Recipient ◽

Pure Red Cell Aplasia ◽

Red Cell ◽

Erythroid Progenitor ◽

Red Cell Aplasia

Parvo B19 is a single stranded DNA virus, which typically has affi nity for erythroid progenitor cells in the bone marrow and produces a severe form of anemia known as pure red cell aplasia. This condition is particularly worse in immunocompromised individuals. We herein report a young Nepali male who developed severe and persistent anaemia after kidney transplantation while being on immunosuppressive therapy. His bone marrow examination revealed morphological changes of pure red cell aplasia, caused by parvovirus B19. The IgM antibody against the virus was positive and the virus was detected by polymerase chain reaction in the blood. He was managed with intravenous immunoglobulin. He responded well to the treatment and has normal hemoglobin levels three months post treatment. To the best of our knowledge, this is the fi rst such case report from Nepal. Keywords: Intravenous immunoglobulin, kidney transplant recipient, Parvovirus B19, pure red cell aplasia.

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Reduced intensity conditioning bone marrow transplantation for pure red cell aplasia: successful outcome but difficult post transplant course

Bone Marrow Transplantation ◽

10.1038/sj.bmt.1704993 ◽

2005 ◽

Vol 36 (1) ◽

pp. 81-82 ◽

Cited By ~ 6

Author(s):

G Kochethu ◽

H S Baden ◽

E Jaworska ◽

J Chang ◽

R Chopra

Keyword(s):

Bone Marrow ◽

Bone Marrow Transplantation ◽

Marrow Transplantation ◽

Pure Red Cell Aplasia ◽

Successful Outcome ◽

Red Cell ◽

Reduced Intensity Conditioning ◽

Post Transplant ◽

Red Cell Aplasia ◽

Reduced Intensity

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Carbamazepine-Induced Pure Red Cell Aplasia

International Journal of Epilepsy ◽

10.1055/s-0038-1657851 ◽

2018 ◽

Vol 05 (01) ◽

pp. 050-052 ◽

Cited By ~ 1

Author(s):

C. Mansoor ◽

Laksmi Priya

Keyword(s):

Bone Marrow ◽

Rare Disease ◽

Pure Red Cell Aplasia ◽

Normocytic Anemia ◽

Red Cell ◽

Normal Bone Marrow ◽

Hematologic Disorders ◽

Normal Bone ◽

Red Cell Aplasia ◽

Carbamazepine Therapy

AbstractAntiepileptic therapy is associated with various hematologic disorders. Pure red cell aplasia (PRCA) is a rare disease that may be congenital or acquired. Severe normocytic anemia, reticulocytopenia, and absence of erythroblasts from an otherwise normal bone marrow should raise the suspicion of PRCA. A 32-year-old unmarried woman was admitted with fatigue for 4 months. She had been on carbamazepine therapy for 4 years (200 mg twice daily) for seizure disorder. On evaluation, she was diagnosed to have PRCA secondary to carbamazepine. We describe a patient with carbamazepine-induced PRCA that improved after discontinuation of the drug.

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