EXPERIENCE OF COMBINING PLATELET-RICH AUTOPLASM THERAPY AND LOW-INTENSITY SHOCK-WAVE THERAPY IN TREATMENT OF PEYRONIE’S DISEASE

Men’s Health, Gender and Psychosomatic Medicine ◽

10.37321/ujmh.2018.02-01 ◽

2019 ◽

pp. 12-18

Author(s):

Юрий Заседа

Keyword(s):

Growth Factors ◽

Peyronie’S Disease ◽

Health Clinic ◽

Penile Induration ◽

Combined Use ◽

Reduction Of Pain ◽

Icd 10 ◽

Peyronie's Disease ◽

Therapeutic Model

Relevance. The spectrum of combined mechanisms of action of PRP-therapy, LISWT and LNP therapy suggests the clinical eff ect for patients with fi broplastic penile induration, which currently does not have conservative therapies that have suffi cient effi cacy.The aim of the study was to determine the effi cacy of combined PRP-therapy with intracavernous activation of growth factors by LISWT method + LNP and ICA pharmacotherapy in treatment of fi broplastic penile induction.Design. The study group comprised 23 patients of the Men’s Health Clinic in Kyiv, suff ering from fi broplastic penile inducing (Peyronie’s disease, ICD-10: N48.6) with erectile dysfunction.Results of the study. A 6-month follow-up observation showed a reduction of pain during erection, a signifi cant improvement in erectile function, a total regression of the areas less than 25 mm2 and a signifi cant decrease in the density and area of the induration areas that over 25 mm2. Conclusions. It has been established that the therapeutic model of the combined use of PRP-therapy with intracavernous activation of growth factors by LISWT method + LOD + ICA in the treatment of fi broplastic penile induration, shows a pronounced clinical eff ect, which makes this therapeutic model a promising option for conservative correction of pain and erectile dysfunction in fi broplastic penile induration.

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EXPERIENCE OF PREMATURE EJACULATION CORRECTION BY COMBINED THERAPY OF PLATELET-RICH PLASMA AND LOW-INTENSITY SHOCK-WAVE THERAPY

Men’s Health, Gender and Psychosomatic Medicine ◽

10.37321/ujmh.2018.02-02 ◽

2019 ◽

pp. 33-38

Author(s):

Юрий Заседа

Keyword(s):

Growth Factors ◽

Platelet Rich Plasma ◽

Combined Therapy ◽

Health Clinic ◽

Penile Induration ◽

Combined Use ◽

Reduction Of Pain ◽

Icd 10 ◽

Therapeutic Model

Relevance. The spectrum of combined mechanisms of action of PRP-therapy, LISWT and LNP therapy suggests the clinical eff ect for patients with fi broplastic penile induration, which currently does not have conservative therapies that have suffi cient effi cacy.The aim of the study was to determine the effi cacy of combined PRP-therapy with intracavernous activation of growth factors by LISWT method + LNP and ICA pharmacotherapy in treatment of fi broplastic penile induction.Design. The study group comprised 23 patients of the Men’s Health Clinic in Kyiv, suff ering from fi broplastic penile inducing (Peyronie’s disease, ICD-10: N48.6) with erectile dysfunction.Results of the study. A 6-month follow-up observation showed a reduction of pain during erection, a signifi cant improvement in erectile function, a total regression of the areas less than 25 mm2 and a signifi cant decrease in the density and area of the induration areas that over 25 mm2.Conclusions. It has been established that the therapeutic model of the combined use of PRP-therapy with intracavernous activation of growth factors by LISWT method + LOD + ICA in the treatment of fi broplastic penile induration, shows a pronounced clinical eff ect, which makes this therapeutic model a promising option for conservative correction of pain and erectile dysfunction in fi broplastic penile induration.

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Surgical Correction of Peyronie's Disease via Tunica Albuginea Plication or Partial Plaque Excision with Pericardial Graft: Long Term Follow‐Up: An Editorial Comment

Journal of Sexual Medicine ◽

10.1111/j.1743-6109.2008.00943.x ◽

2008 ◽

Vol 5 (9) ◽

pp. 2229

Author(s):

David Ralph

Keyword(s):

Editorial Comment ◽

Tunica Albuginea ◽

Peyronie’S Disease ◽

Surgical Correction ◽

Long Term Follow Up ◽

Peyronie's Disease

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Buccal mucosa is a promising graft in Peyronie’s disease surgery. Our experience and a brief literature review on autologous grafting materials

Archivio Italiano di Urologia e Andrologia ◽

10.4081/aiua.2016.2.115 ◽

2016 ◽

Vol 88 (2) ◽

pp. 115 ◽

Cited By ~ 2

Author(s):

Andrea Fabiani ◽

Lucilla Servi ◽

Fabrizio Fioretti ◽

Valentina Maurelli ◽

Flavia Tombolini ◽

...

Keyword(s):

Literature Review ◽

Buccal Mucosa ◽

Peyronie’S Disease ◽

Benign Condition ◽

Buccal Mucosa Graft ◽

Harvesting Technique ◽

Clinical Series ◽

Peyronie's Disease ◽

Grafting Materials

Aim: Peyronie’s Disease (PD) is an under reported acquired benign condition that, at the moment, is not curable with medical therapy. Surgery represent the gold standard of treatment. Surgical approaches are several and they consist in “plication techniques” or plaque incision/excision with grafting of resulting albuginea defect. Among grafting procedures, albuginea defect substitution with autologous materials demonstrated over the years not inferior results respect to heterologous grafts. Buccal mucosa graft (BMG) is not usually emphasized in many review articles and clinical series are yet limited. Methods: We present our experience with seventeen plaque incision procedures and BMG in surgical correction of complex penile curvatures due to PD performed in a period of 30 months. Our analyses was focused on buccal mucosa graft characteristics as major determinant of the surgical success. We also conducted a brief literature review on autologous grafting materials used in reconstructive penile surgery for PD. Results: Our cosmetics and functional results consists in a 100% of functional penile straightening with no relapses and 5,8% of de novo erectile dysfunction. Mean age was 56.4 years, mean follow-up of 22.5 (6-36) months. No complications graft related were observed. Operative time was 115.3 minutes in mean. Over 94% of patients referred they were “really much better” and “much better” satisfied based on PGI-I questionnaire administrated at the last follow- up visit. Conclusion: BMG is revealing as an optimal choice for reconstructive surgery in PD. Anatomical characteristics consisting in the great elasticity, the quick integration time and the easy harvesting technique lead to high cosmetics and functional success rate, without omitting economical and invasiveness aspects.

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