scholarly journals Coagulopathy due to vitamin k-dependent coagulation factors deficit as a unusual presentation of celiac disease

2021 ◽  
Vol 44 (6) ◽  
pp. 533-536
Author(s):  
KM Gómez Torres ◽  
JA Vázquez Rodríguez ◽  
C Molina Villalba
Keyword(s):  
Celiac Disease ◽  
Vitamin K ◽  
Coagulation Factors ◽  
Unusual Presentation

Resumen El gluten es una proteína presente principalmente en el trigo, cebada y centeno, que se utiliza ampliamente en el procesamiento de varios alimentos. Su ingesta se ha asociado con una variedad de trastornos clínicos de relevancia epidemiológica, denominados en conjunto trastornos relacionados con el gluten. De ellos, la enfermedad celíaca es la más importante por su implicancia clínica. La enfermedad celíaca se reconoce fundamentalmente por su clínica digestiva; sin embargo, su espectro de presentación puede ser muy amplio. Se presenta el caso de un paciente con antecedente de episodios hemorrágicos sin causa aparente, que concluyó en el diagnóstico de Enfermedad Celíaca, al presentar posteriormente clínica digestiva. Este caso enfatiza la necesidad de tener en consideración el diagnóstico de celiaquía ante un paciente con coagulopatía de origen desconocido, que permita instaurar de forma oportuna el tratamiento adecuado para evitar complicaciones.

Increased Activity of Vitamin K-Dependent Clotting Factors in Human Hyperlipoproteinaemia – Association with Cholesterol and Triglyceride Levels

1977 ◽  
Vol 38 (02) ◽  
pp. 0465-0474 ◽  
Author(s):  
M Constantino ◽  
C Merskey ◽  
D. J Kudzma ◽  
M. B Zucker
Keyword(s):  
Vitamin K ◽  
Plasma Lipids ◽  
Coagulation Factors ◽  
Clotting Factor ◽  
Factor X ◽  
Clotting Factors ◽  
Blood Coagulation Factors ◽  
Cholesterol Levels ◽  
Type V ◽  
Increased Activity

SummaryLevels of blood coagulation factors, cholesterol and triglyceride were measured in human plasma. Prothrombin was significantly elevated in type Ha hyperlipidaemia; prothrombin and factors VII, IX and X in type lib; and prothrombin and factors VII and IX in type V. Multiple regression analysis showed significant correlation between the levels of these plasma lipids and the vitamin K-dependent clotting factors (prothrombin, factors VII, IX and X). Higher cholesterol levels were associated with higher levels of prothrombin and factor X while higher triglyceride levels were associated with higher levels of these as well as factors VII and IX. Prothrombin showed a significant cholesterol-triglyceride interaction in that higher cholesterol levels were associated with higher prothrombin levels at all levels of triglyceride, with the most marked effects in subjects with higher triglyceride levels. Higher prothrombin levels were noted in subjects with high or moderately elevated (but not low) cholesterol levels. Ultracentrifugation of plasma in a density of 1.21 showed activity for prothrombin and factors VII and X only in the lipoprotein-free subnatant fraction. Thus, a true increase in clotting factor protein was probably present. The significance of the correlation between levels of vitamin K-dependent clotting factors and plasma lipids remains to be determined.

scholarly journals Haplotypes of VKORC1, NQO1 and GGCX, their effect on activity levels of vitamin K-dependent coagulation factors, and the risk of venous thrombosis

2011 ◽  
Vol 106 (09) ◽  
pp. 563-565 ◽  
Author(s):  
Sara Roshani ◽  
Julie Rutten ◽  
Astrid van Hylckama Vlieg ◽  
Hans Vos ◽  
Frits Rosendaal ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Vitamin K ◽  
Coagulation Factors ◽  
Activity Levels

Rat Coagulation Factors V, VIII, XI, and XII: Vitamin K Dependent

1978 ◽  
Vol 7 (4) ◽  
pp. 189-201
Author(s):  
Charles A. Owen, jr. ◽  
Walter Bowie
Keyword(s):  
Vitamin K ◽  
Coagulation Factors

scholarly journals Vitamin K-Dependent Coagulation Factors That May be Responsible for Both Bleeding and Thrombosis (FII, FVII, and FIX)

2018 ◽  
Vol 24 (9_suppl) ◽  
pp. 42S-47S ◽  
Author(s):  
Antonio Girolami ◽  
Silvia Ferrari ◽  
Elisabetta Cosi ◽  
Claudia Santarossa ◽  
Maria Luigia Randi
Keyword(s):  
Venous Thrombosis ◽  
Vitamin K ◽  
Protein C ◽  
Protein S ◽  
Coagulation Factors ◽  
Bleeding Tendency ◽  
Clotting Factors ◽  
Protein Z ◽  
Clinical Observations

Vitamin K-dependent clotting factors are commonly divided into prohemorrhagic (FII, FVII, FIX, and FX) and antithrombotic (protein C and protein S). Furthermore, another protein (protein Z) does not seem strictly correlated with blood clotting. As a consequence of this assumption, vitamin K-dependent defects were considered as hemorrhagic or thrombotic disorders. Recent clinical observations, and especially, recent advances in molecular biology investigations, have demonstrated that this was incorrect. In 2009, it was demonstrated that the mutation Arg338Leu in exon 8 of FIX was associated with the appearance of a thrombophilic state and venous thrombosis. The defect was characterized by a 10-fold increased activity in FIX activity, while FIX antigen was only slightly increased (FIX Padua). On the other hand, it was noted on clinical grounds that the thrombosis, mainly venous, was present in about 2% to 3% of patients with FVII deficiency. It was subsequently demonstrated that 2 mutations in FVII, namely, Arg304Gln and Ala294Val, were particularly affected. Both these mutations are type 2 defects, namely, they show low activity but normal or near-normal FVII antigen. More recently, in 2011-2012, it was noted that prothrombin defects due to mutations of Arg596 to Leu, Gln, or Trp in exon 15 cause the appearance of a dysprothrombinemia that shows no bleeding tendency but instead a prothrombotic state with venous thrombosis. On the contrary, no abnormality of protein C or protein S has been shown to be associated with bleeding rather than with thrombosis. These studies have considerably widened the spectrum and significance of blood coagulation studies.

scholarly journals Two Types of Prothrombin in Vitamin K Deficiency

1970 ◽  
Vol 23 (03) ◽  
pp. 633-637 ◽  
Author(s):  
H. C Hemker ◽  
Annemarie D. Muller ◽  
E. A Loeliger
Keyword(s):  
Vitamin K ◽  
Oral Anticoagulants ◽  
Coagulation Factors ◽  
The Other ◽  
Vitamin K Deficiency ◽  
Two Stage ◽  
K Deficiency

SummaryIn vitamin K deficiency (either absolute or induced by oral anticoagulants) two types of prothrombin occur. One is not distinguishable from normal prothrombin. It generates thrombin quickly in a medium in which the factors V, VII and X, thromboplastin and Ca++ are present in sufficient amounts. The other is converted into thrombin much more slowly under the same conditions. In the onestage prothrombin assay only the first form is measured, in a two-stage prothrombin assay both forms are estimated. This accounts for the well-known discrepancy between these two tests in vitamin K deficiency. The abnormal prothrombin can be considered one of the Proteins Induced by Vitamin K Absence. The occurrence of this kind of proteins fits in the concept of the action of vitamin K as a co-factor in a system that converts polypeptide-precursors into coagulation factors.

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