scholarly journals Warm ischemia time and elevated serum uric acid are associated with metabolic syndrome after liver transplantation with donation after cardiac death

2018 ◽  
Vol 24 (43) ◽  
pp. 4920-4927
Author(s):  
Liang-Shuo Hu ◽  
Yi-Chao Chai ◽  
Jie Zheng ◽  
Jian-Hua Shi ◽  
Chun Zhang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Liver Transplantation ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Cardiac Death ◽  
Elevated Serum ◽  
Warm Ischemia ◽  
Warm Ischemia Time ◽  
Donation After Cardiac Death ◽  
Ischemia Time

Successful donation after cardiac death liver transplants with prolonged warm ischemia time using normothermic regional perfusion

2016 ◽  
Vol 23 (2) ◽  
pp. 166-173 ◽  
Author(s):  
Riccardo De Carlis ◽  
Stefano Di Sandro ◽  
Andrea Lauterio ◽  
Fabio Ferla ◽  
Antonio Dell'Acqua ◽  
...  
Keyword(s):  
Cardiac Death ◽  
Warm Ischemia ◽  
Warm Ischemia Time ◽  
Regional Perfusion ◽  
Donation After Cardiac Death ◽  
Liver Transplants ◽  
Ischemia Time ◽  
Normothermic Regional Perfusion

Endovascular Aortic Crossclamp: A Novel Way to Reduce Warm Ischemia Time in DCD Donors

2008 ◽  
Vol 74 (12) ◽  
pp. 1198-1201 ◽  
Author(s):  
Oscar H. Grandas ◽  
Jose D. Amortegui ◽  
Mitchell H. Goldman
Keyword(s):  
Prognostic Factor ◽  
Cardiac Death ◽  
Patient Survival ◽  
Cardiac Activity ◽  
Warm Ischemia ◽  
Warm Ischemia Time ◽  
Donation After Cardiac Death ◽  
Organ Function ◽  
Surgical Time ◽  
Ischemia Time

Strategies like donation after cardiac death (DCD) have become more widely accepted to increase potential organ supply and decrease waiting list time. Warm ischemia time (WIT) is a key prognostic factor for organ function. Any process that can decrease WIT could decrease the number of discarded organs as well as improve graft and patient survival. A novel endovascular aortic crossclamping technique in DCD donors is described. Six kidneys and two livers were recovered from three donors. Mean WIT from extubation to aortic crossclamp was 25 ± 8 minutes. Time from initial glidewire placement to crossclamp was less than 2 minutes. All the organs were adequately flushed; back table examination confirmed clean venous effluent and no signs of thrombosis. Four kidneys were transplanted. Two kidneys were discarded after DCD was prolonged and WIT was 60 minutes. The two livers were not allocated. The WIT can be manipulated after cardiac activity has stopped. The endovascular crossclamp is a novel and feasible technique that can decrease WIT after cardiac death by reducing the surgical time to aortic crossclamp.

Short recipient warm ischemia time improves outcomes in deceased donor liver transplantation

2021 ◽  
Author(s):  
Abbas Al‐Kurd ◽  
Toshihiro Kitajima ◽  
Khortnal Delvecchio ◽  
Mhd Tayseer Shamaa ◽  
Tommy Ivanics ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Deceased Donor ◽  
Warm Ischemia ◽  
Warm Ischemia Time ◽  
Donor Liver ◽  
Ischemia Time ◽  
Donor Liver Transplantation ◽  
Deceased Donor Liver Transplantation

scholarly journals Lack of Associations between Elevated Serum Uric Acid and Components of Metabolic Syndrome Such as Hypertension, Dyslipidemia, and T2DM in Overweight and Obese Chinese Adults

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Li Li ◽  
Qifa Song ◽  
Xi Yang
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Blood Glucose ◽  
Serum Uric Acid ◽  
Muscle Mass ◽  
Alanine Aminotransferase ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Elevated Serum ◽  
Chinese Adults

The overweight and obese population experiences a higher occurrence of both hyperuricemia and metabolic syndrome. The present study was to explore the relationship between serum uric acid and metabolic syndrome-related risk factors among 409 obese Chinese adults (254 women and 155 men) with >24 kg/m2 BMI. Based on sex-specific reference ranges, 233 (57%) patients showed elevated serum uric acid. A total of 15 attributes were selected to assess the associations between elevated serum uric acid and components of metabolic syndrome, including serum uric acid, total cholesterol, HDL-C, LDL-C, triglyceride, systolic blood pressure, fasting blood glucose, glycosylated hemoglobin, HOMA-IR, alanine aminotransferase, creatinine, urine microalbumin, muscle mass amount, BMI, and age. Among the participants stratified into three groups of grade I, grade II, and grade III obesity, as well as among the participants stratified into male and female groups, univariate correlation analysis identified a negative association (P<0.01) for age, positive associations (P<0.01) for BMI, muscle mass, alanine aminotransferase, and creatinine. The stepwise multivariate logistic regression proved similar associations for age, BMI, creatinine, and alanine aminotransferase. No significant associations were testified between serum uric acid levels and cholesterol, HDL-C, LDL-C, triglyceride, fasting blood glucose, glycosylated hemoglobin, HOMA-IR, and urine microalbumin. Factor analysis illustrated that 15 attributes could be grouped into two common factors and five individual factors. A common underlying factor was identified among uric acid, muscle mass, creatinine, alanine aminotransferase, and BMI. The results indicate that serum uric acid has no apparent association with metabolic syndromes that are commonly characterized by hypertension, dyslipidemia, and T2DM.

Influence of warm ischemia time on initial graft function in human liver transplantation

1997 ◽  
Vol 29 (8) ◽  
pp. 3458-3459 ◽  
Author(s):  
K.-P. Platz ◽  
A.R. Mueller ◽  
C. Schäfer ◽  
S. Jahns ◽  
O. Guckelberger ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Human Liver ◽  
Graft Function ◽  
Warm Ischemia ◽  
Warm Ischemia Time ◽  
Ischemia Time

scholarly journals Onset of Donor Warm Ischemia Time in Donation After Circulatory Death Liver Transplantation: Hypotension or Hypoxia?

2018 ◽  
Vol 24 (8) ◽  
pp. 1001-1010 ◽  
Author(s):  
Marit Kalisvaart ◽  
Jubi E. de Haan ◽  
Wojciech G. Polak ◽  
Jan N. M. IJzermans ◽  
Diederik Gommers ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Warm Ischemia ◽  
Warm Ischemia Time ◽  
Donation After Circulatory Death ◽  
Ischemia Time ◽  
Circulatory Death

Vein Suturing Results in Worse Lung Graft Outcomes Compared to the Cuff Method

2019 ◽  
Vol 60 (3-4) ◽  
pp. 106-116
Author(s):  
Davide Zampieri ◽  
Nadia Azzollini ◽  
Stefania Vuljan ◽  
Federica Pezzuto ◽  
Sonia Fiori ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Left Lung ◽  
Warm Ischemia ◽  
Warm Ischemia Time ◽  
Donation After Cardiac Death ◽  
Brown Norway ◽  
Ischemia Time ◽  
Lung Transplants

Background: The rat orthotopic lung transplant model is not widely used yet because of the complexity of the procedure, in particular, venous anastomosis. Here, we performed a rat orthotopic lung transplantation using either the suture (ST) or cuff (CT) method for vein anastomosis. Objectives: To compare the vein ST and CT techniques in terms of operative time, success, recipient survival, and early histological outcomes was the objective of this study. Methods: A total of 24 left lung transplants in rats were performed. Twelve syngeneic (Lewis to Lewis) and 12 allogeneic (Brown-Norway to Lewis) lung transplants were performed using either the vein ST or the CT procedure. Arterial and bronchial anastomoses were performed with the CT technique. Graft histological damage was evaluated 3–7 days post-transplant in all rat lungs. Results: The surgical success rate was 75% in both the ST and CT groups. Failures related mainly to vein bleeding (n = 2 in the ST group) and thrombosis (n = 1 in the ST group; n = 2 in the CT group). Total ischemia time was longer in the ST group (122 ± 25 min in ST group vs. 83 ± 10 min in CT group, mean ± SD), due to prolonged warm ischemia time (60 ± 12 min in the ST group vs. 21 ± 5 min in the CT group, mean ± SD), reflecting the time required to complete the vein ST procedure. The prolonged warm ischemia time resulted in significantly higher vascular inflammation in syngeneic grafts (2.3 ± 1.2 ST group vs. 0 in the CT group, mean ± SD) and in increased severity of ischemia/reperfusion injury and acute graft rejection (3.6 ± 0.4 in the ST group vs. 2.6 ± 0.4 in the CT group, mean ± SD) in allogeneic lung transplants. Conclusions: The vein ST technique is a more time-consuming procedure than the CT method and the prolonged anastomosis time has a deleterious impact on transplant outcomes. These findings suggest that warm ischemia time – one of the modifiable transplant factors – should be considered a major risk factor in lung transplantation, particularly in the setting of donation after cardiac death.

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