scholarly journals The Diagnostic Role of Anti-Human Salivary Gland Protein-1 (anti-SP1) in the Early Detection of Primary Sjogren’s Syndrome in Some Iraqi Patients

2020 ◽  
Keyword(s):  
Salivary Gland ◽  
Early Detection ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Human Salivary Gland ◽  
Salivary Gland Protein ◽  
Diagnostic Role

scholarly journals B7-H2 Expression in Human Salivary Gland Epithelial Cells Affects Saliva Secretion in Primary Sjögren's Syndrome

2021 ◽  
Author(s):  
Ping Li ◽  
Yi Jin ◽  
Rui Zhao ◽  
Zhonghui Xue ◽  
Juan Ji
Keyword(s):  
Salivary Gland ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Human Salivary Gland ◽  
Sjögren‘S Syndrome

Abstract Primary Sjögren's syndrome (pSS) is a chronic inflammatory autoimmune disease of exocrine gland. In pSS, permanent activation of the adaptive immune system is obvious. Lymphocyte co-stimulation plays an important part in inflammation and immunotherapy. Co-stimulator ligands (B7-H2) are significant costimulatory molecules. The interaction of B7-H2, with its sole receptor ICOS, promotes T cell differentiation, effector responses and activation. Our study found that B7-H2 is up-regulated in salivary gland, saliva and serum of pSS patients. B7-H2 expression in saliva have negatively correlated with saliva weight. Overexpression of B7-H2 into human salivary gland epithelial (HSGE) cells, increased the activity of p65 (phosphorylated at S536) and decreased the expression of AQP5. Furthermore, up-regulated B7-H2 induced apoptosis and inhibited proliferation in HSGE cell lines. These results suggest the expression of B7-H2 can decrease the secretion of saliva, increase the quantity of dental caries and reduce lifespan of patients of pSS.

scholarly journals Ultrasound and Bioptic Investigation of Patients with Primary Sjögren’s Syndrome

2021 ◽  
Vol 10 (6) ◽  
pp. 1171
Author(s):  
Valeria Manfrè ◽  
Ivan Giovannini ◽  
Sara Zandonella Callegher ◽  
Michele Lorenzon ◽  
Enrico Pegolo ◽  
...  
Keyword(s):  
Salivary Gland ◽  
B Cell ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Sjögren‘S Syndrome

Primary Sjögren’s syndrome (pSS) is a chronic and heterogeneous disorder characterized by a wide spectrum of glandular and extra-glandular features. The hallmark of pSS is considered to be the immune-mediated involvement of the exocrine glands and B-cell hyperactivation. This leads pSS patients to an increased risk of developing lymphoproliferative diseases, and persistent (>2 months) major salivary gland enlargement is a well-known clinical sign of possible involvement by B cell lymphoma. Better stratification of the patients may improve understanding of the mechanism underlying the risk of lymphoproliferative disorder. Here, we summarize the role of different imaging techniques and a bioptic approach in pSS patients, focusing mainly on the role of salivary gland ultrasonography (SGUS) and a US-guided core needle biopsy (Us-guided CNB) as diagnostic and prognostic tools in pSS patients with persistent parotid swelling.

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