Asymmetric total synthesis of smyrindiol employing an organocatalytic aldol key step
2012 ◽
Vol 8
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pp. 1112-1117
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The first organocatalytic asymmetric synthesis of smyrindiol, by using an (S)-proline catalyzed enantioselective intramolecular aldol reaction as the key step, is described. Smyrindiol was synthesized from commercially available 2,4-dihydroxybenzaldehyde in 15 steps, with excellent stereoselectivity (de = 99%, ee = 99%). In the course of this total synthesis a new and mild coumarin assembly was developed.
2018 ◽
Vol 96
(12)
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pp. 1061-1063
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Keyword(s):
1982 ◽
Vol 23
(33)
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pp. 3401-3404
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2016 ◽
Vol 2016
(28)
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pp. 4834-4841
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Keyword(s):