scholarly journals Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

10.3791/51807 ◽  
2014 ◽  
Author(s):  
F. Aura Kullmann ◽  
Stephanie L. Daugherty ◽  
William C. de Groat ◽  
Lori A. Birder
Keyword(s):  
Smooth Muscle ◽  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Muscle Strip ◽  
Bladder Smooth Muscle ◽  
Lower Urinary

The role of smooth muscle and its possible involvement in diseases of the lower urinary tract

1986 ◽  
Vol 70 (S14) ◽  
pp. 7s-13s ◽  
Author(s):  
A. F. Brading ◽  
J. L. Mostwin ◽  
G. N. A. Sibley ◽  
M. J. Speakman
Keyword(s):  
Smooth Muscle ◽  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Lower Urinary

Increased autophagy contributes to impaired smooth muscle function in neurogenic lower urinary tract dysfunction

2018 ◽  
Vol 37 (8) ◽  
pp. 2414-2424
Author(s):  
Daniel Eberli ◽  
Maya Horst ◽  
Ashkan Mortezavi ◽  
Karl-Erik Andersson ◽  
Rita Gobet ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Urinary Tract ◽  
Muscle Function ◽  
Lower Urinary Tract ◽  
Lower Urinary Tract Dysfunction ◽  
Smooth Muscle Function ◽  
Lower Urinary

scholarly journals Laboratory practical to study the differential innervation pathways of urinary tract smooth muscle

2018 ◽  
Vol 42 (2) ◽  
pp. 295-304 ◽  
Author(s):  
Benjamin E. Rembetski ◽  
Caroline A. Cobine ◽  
Bernard T. Drumm
Keyword(s):  
Smooth Muscle ◽  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Sympathetic Nerves ◽  
Reciprocal Relationship ◽  
Adrenergic Stimulation ◽  
Key Factors ◽  
Contractile State ◽  
Urethral Smooth Muscle ◽  
Lower Urinary

In the mammalian lower urinary tract, there is a reciprocal relationship between the contractile state of the bladder and urethra. As the bladder fills with urine, it remains relaxed to accommodate increases in volume, while the urethra remains contracted to prevent leakage of urine from the bladder to the exterior. Disruptions to the normal contractile state of the bladder and urethra can lead to abnormal micturition patterns and urinary incontinence. While both the bladder and urethra are smooth-muscle organs, they are differentially contracted by input from cholinergic and sympathetic nerves, respectively. The laboratory practical described here provides an experiential approach to understanding the anatomy of the lower urinary tract. Several key factors in urinary tract physiology are outlined, e.g., the bladder is contracted by activation of the parasympathetic pathway via cholinergic stimulation on muscarinic receptors, whereas the urethra is contracted by activation of the sympathetic pathway via adrenergic stimulation on α1-adrenoceptors. This is achieved by measuring the force generated by bladder and urethra smooth muscle to demonstrate that acetylcholine contracts the smooth muscle of the bladder, whereas adrenergic agonists contract the urethral smooth muscle. An inhibition of these effects is also demonstrated by application of the muscarinic receptor antagonist atropine and the α1-adrenergic receptor blocker phentolamine. A list of suggested techniques and exam questions to evaluate student understanding on this topic is also provided.

Influence of Serotonin on Lower Urinary Tract Smooth Muscle in Vitro

1986 ◽  
Vol 58 (5) ◽  
pp. 507-513 ◽  
Author(s):  
P. KLARSKOV ◽  
J. HØRBY-PETERSEN
Keyword(s):  
Smooth Muscle ◽  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Lower Urinary
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