Introduction. Malignant transformation is a rare complication of mature
cystic teratoma, with squamous cell carcinoma as the most common malignancy
(in 75% of cases). In this article we present a case of a well-differentiated
squamous cell carcinoma arising in a mature cystic teratoma and discuss the
morphological and clinico-pathological features of malignant transformation
in teratoma. Case Report. An 80-year-old woman with symptoms of acute abdomen
underwent left salpingo-oophorectomy. Gross examination showed a cystic mass
measuring 20 cm in diameter, with papillary formation on its internal
surface. Histology revealed a well-differentiated squamous cell carcinoma
arising in mature cystic teratoma. Squamous epithelium surrounding the tumor
was dysplastic. Conclusion. Squamous cell carcinoma in mature cystic teratoma
is a rare pathologic event and in most cases it is an accidental
pathohistological finding.
Mature cystic teratoma of the ovary with keratinizing squamous cell carcinoma
