Intermittent fasting modulation of the diabetic syndrome in sand rats. III. Post-mortem investigations

This study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats). Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the intermittently fasting animals. Intermittent fasting improved glucose tolerance, increased plasma insulin, and lowered Homeostatis Model Assessment index. Caloric restriction failed to cause such beneficial effects. Theβ-cell mass, as well as individualβ-cell and islet area, was higher in intermittently fasting than in nonfasting STZ rats, whilst the percentage of apoptoticβ-cells appeared lower in the former than latter STZ rats. In the calorie-restricted STZ rats, comparable findings were restricted to individual islet area and percentage of apoptotic cells. Hence, it is proposed that intermittent fasting could represent a possible approach to prevent or minimize disturbances of glucose homeostasis in human subjects.

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Ultrastructural investigation of an adenoma of the pituitary post mortem

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100127542 ◽

1987 ◽

Vol 45 ◽

pp. 622-623

Author(s):

Shirley Siew ◽

W. C. deMendonca

Keyword(s):

Deleterious Effect ◽

Anterior Lobe ◽

Definitive Diagnosis ◽

Pars Intermedia ◽

Post Mortem ◽

Close Apposition ◽

Autopsy Material ◽

Progressive Loss ◽

Transmission Electron ◽

Means Of Transmission

The deleterious effect of post mortem degeneration results in a progressive loss of ultrastructural detail. This had led to reluctance (if not refusal) to examine autopsy material by means of transmission electron microscopy. Nevertheless, Johannesen has drawn attention to the fact that a sufficient amount of significant features may be preserved in order to enable the establishment of a definitive diagnosis, even on “graveyard” tissue.Routine histopathology of the autopsy organs of a woman of 78 showed the presence of a well circumscribed adenoma in the anterior lobe of the pituitary. The lesion came into close apposition to the pars intermedia. Its architecture was more compact and less vascular than that of the anterior lobe. However, there was some grouping of the cells in relation to blood vessels. The cells tended to be smaller, with a higher nucleocytoplasmic ratio. The cytoplasm showed a paucity of granules. In some of the cells, it was eosinophilic.

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Post-Mortem Review and Genetic Analysis of Sudden Unexpected Death in Epilepsy (SUDEP) Cases

Yearbook of Neurology and Neurosurgery ◽

10.1016/j.yneu.2011.04.011 ◽

2011 ◽

Vol 2011 ◽

pp. 42-43

Author(s):

M.J. Brodie

Keyword(s):

Genetic Analysis ◽

Sudden Unexpected Death ◽

Post Mortem ◽

Unexpected Death

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Post-mortem Peyer’s patches: Their potential application in forensic medicine

Immunopharmacology and Immunotoxicology ◽

10.1080/08923970902902437 ◽

2009 ◽

Vol 00 (00) ◽

pp. 090513010017019-7

Author(s):

Biagio Solarino ◽

Giancarlo Di Vella ◽

Thea Magrone ◽

Felicita Jirillo ◽

Angela Tafaro ◽

...

Keyword(s):

Forensic Medicine ◽

Potential Application ◽

Peyer's Patches ◽

Peyer’S Patches ◽

Post Mortem

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Aneurysms in the history of medicine

VASA ◽

10.1024/0301-1526.31.4.281 ◽

2002 ◽

Vol 31 (4) ◽

pp. 281-286 ◽

Cited By ~ 3

Author(s):

Bollinger ◽

Rüttimann

Keyword(s):

History Of Medicine ◽

Albert Einstein ◽

Thomas Mann ◽

Post Mortem ◽

John Hunter ◽

History Of

Die Geschichte des sackförmigen oder fusiformen Aneurysmas reicht in die Zeit der alten Ägypter, Byzantiner und Griechen zurück. Vesal 1557 und Harvey 1628 führten den Begriff in die moderne Medizin ein, indem sie bei je einem Patienten einen pulsierenden Tumor intra vitam feststellten und post mortem verifizierten. Weitere Eckpfeiler bildeten die Monographien von Lancisi und Scarpa im 18. bzw. beginnenden 19. Jahrhundert. Die erste wirksame Therapie bestand in der Kompression des Aneurysmasacks von außen, die zweite in der Arterienligatur, der John Hunter 1785 zum Durchbruch verhalf. Endoaneurysmoraphie (Matas) und Umhüllung mit Folien wurden breit angewendet, bevor Ultraschalldiagnostik und Bypass-Chirurgie Routineverfahren wurden und die Prognose dramatisch verbesserten. Die diagnostischen und therapeutischen Probleme in der Mitte des 20. Jahrhunderts werden anhand von zwei prominenten Patienten dargestellt, Albert Einstein und Thomas Mann, die beide im Jahr 1955 an einer Aneurysmaruptur verstarben.

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