scholarly journals Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3

2007 ◽  
Author(s):  
Soung Park ◽  
Gi Kim ◽  
Song-Ja Bae ◽  
Young Yoo ◽  
Yung Choi
Keyword(s):  
Cervical Carcinoma ◽  
Hepg2 Cells ◽  
Caspase 3 ◽  
Human Cervical Carcinoma ◽  
Induction Of Apoptosis

Induction of apoptosis in human cervical carcinoma HeLa cells by neoechinulin A from marine-derived fungus Microsporum sp.

2013 ◽  
Vol 48 (1) ◽  
pp. 68-72 ◽  
Author(s):  
Isuru Wijesekara ◽  
Yong-Xin Li ◽  
Thanh-Sang Vo ◽  
Quang Van Ta ◽  
Dai-Hung Ngo ◽  
...  
Keyword(s):  
Cervical Carcinoma ◽  
Hela Cells ◽  
Human Cervical Carcinoma ◽  
Induction Of Apoptosis

Yuk-Hap-Tang Induces Apoptosis by Intervening Mn-SOD in Human Cervical Carcinoma HeLa Cells

2004 ◽  
Vol 32 (06) ◽  
pp. 883-895 ◽  
Author(s):  
H. J. Chae ◽  
J. M. Park ◽  
G. Y. Lee ◽  
H. R. Park ◽  
S. W. Chae ◽  
...  
Keyword(s):  
Cell Death ◽  
Cervical Carcinoma ◽  
Anticancer Agents ◽  
Hela Cells ◽  
Caspase 3 ◽  
Reduced Glutathione ◽  
Cleavage Product ◽  
P53 Expression ◽  
Human Cervical Carcinoma ◽  
Apoptotic Protein

Yuk-Hap-Tang (YHT) induces cell death in human cervical carcinoma HeLa cells. Caspase-3, -6 and -9 were markedly activated in HeLa cells treated with YHT. The preferred substrate for caspase-3 cysteine protease, PARP, was cleaved to its 85-kDa cleavage product. YHT increased the amount of the anti-apoptotic protein, Bcl-2, and the pro-apoptotic protein, Bax. Although p53 has been reported to accumulate in cancer cells in response to anticancer agents, the p53 expression level was not changed in HeLa cells treated with YHT. Manganese (Mn)-TBAP, a mitochondria-specific SOD mimetic agent and NAC/GSH (N-acetyl cysteine/reduced glutathione) reduced the YHT-induced cytotoxicity and decreased the number of the YHT-induced apoptotic cells. Furthermore, YHT reduced the expression of Mn-SOD protein and its activity in HeLa cells. The data demonstrate that YHT induces the apoptosis of human cervical carcinoma HeLa cells by intervening Mn-SOD.

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