Percutaneous Treatment of Long Bone Nonunions: The Use of Autologous Bone Marrow and Allograft Bone Matrix

Background: Various modalities of treatment are available for the management of delayed and nonunion of long bone fractures. The aim of this study was to evaluate the role of percutaneous autologous bone marrow injection in the management of these fractures and to compare the results with studies of other authors as available in literature.Methods: 15 patients with delayed and nonunion of long bone fractures were studied between January 2013 to January 2015 and were followed up for a period of 1 year. The patients were clinically and radiologically evaluated at regular time intervals at follow up.Results: The age of the patients ranged from 28 to 60 years with the mean age being 44.2 years. There was a male preponderance in our study with the male to female ratio being 2:1. The left side was more commonly affected as compared to the right. The mean time to radiological appearance of callus was 6.4 weeks. The mean time to clinical union was 7.33 weeks while the mean time to radiologic union was 13.4 weeks. We had a union rate of 93.3% in our series with one fracture going in for failure of union. Conclusions: Percutaneous autologous bone marrow injection is a minimally invasive, safe and cost effective option in the management of delayed and nonunion of long bone fractures and gives good functional results.

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OUTCOME OF AUTOLOGOUS BONE MARROW INJECTION AT FRACTURE SITE IN DELAYED UNION OF LONG BONE: A SERIES OF 10 CASES

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2016/879 ◽

2016 ◽

Vol 5 (56) ◽

pp. 3841-3843 ◽

Cited By ~ 1

Author(s):

Rajendraprasad Butala ◽

Abhay Agarwal ◽

Ravindra Khedekar G ◽

Nabokrishna Gohain ◽

Amit Grover ◽

...

Keyword(s):

Bone Marrow ◽

Autologous Bone Marrow ◽

Delayed Union ◽

Fracture Site ◽

Long Bone ◽

Autologous Bone

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Percutaneous autologous bone marrow injection for treatment of delayed and non-union of long bone: A retrospective study of 45 cases

Bio-Medical Materials and Engineering ◽

10.3233/bme-141235 ◽

2015 ◽

Vol 25 (s1) ◽

pp. 187-197 ◽

Cited By ~ 2

Author(s):

Jean-Baptiste Gross ◽

Jérôme Diligent ◽

Danièle Bensoussan ◽

Laurent Galois ◽

Jean-François Stoltz ◽

...

Keyword(s):

Bone Marrow ◽

Retrospective Study ◽

Autologous Bone Marrow ◽

Long Bone ◽

Non Union ◽

Autologous Bone

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Comparison of Bone Healing in Open-Wedge High Tibial Osteotomy between the Use of Allograft Bone Chips with Autologous Bone Marrow and the Use of Allograft Bone Chips Alone for Gap Filling

The Journal of Knee Surgery ◽

10.1055/s-0039-1681093 ◽

2019 ◽

Vol 33 (06) ◽

pp. 576-581

Author(s):

Hee-June Kim ◽

Il Seo ◽

Ji-Yeon Shin ◽

Kang San Lee ◽

Kyeong-Hyeon Park ◽

...

Keyword(s):

Bone Marrow ◽

High Tibial Osteotomy ◽

Autologous Bone Marrow ◽

Clinical Results ◽

Tibial Osteotomy ◽

Allograft Bone ◽

Open Wedge ◽

Group A ◽

Autologous Bone ◽

Group B

AbstractThe present study aimed to evaluate whether the use of allograft bone chips mixed with autologous bone marrow (BM) in the high tibial osteotomy (HTO) gap could improve the radiological and clinical results of HTO. This study analyzed 36 patients who underwent HTO with locking plate (mean age: 58.0 years). Allograft bone chips mixed with autologous BM aspirated from anterior superior iliac spine were used in 19 patients (group A) and allograft chips only were used in 17 patients (group B). The radiological and clinical results between two groups were compared during examination at 6 weeks, 3 months, 6 months, and 12 months after surgery. Clinical evaluations involving the Hospital for Special Surgery score, Knee Society knee score, and function score were performed at each assessment point. The osteotomy filling and osteoconductivity using the modified van Hemert's score were compared in each period. The clinical results were not different between the groups at all assessment points. Osteotomy filling was higher at 6 weeks and 3 months in group A than in group B (p = 0.004 and 0.005, respectively). Osteoconductivity was higher at 6 weeks and 3 months in the most medial ¼ zone in group A than in group B (p = 0.025 and 0.031, respectively). Our data shows it is beneficial to mix the allograft bone chips mixed with autologous BM after open-wedge HTO.

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