scholarly journals Splenic Stroma-Educated Regulatory Dendritic Cells Induce Apoptosis of Activated CD4 T Cells via Fas Ligand-Enhanced IFN-γ and Nitric Oxide

2011 ◽  
Vol 188 (3) ◽  
pp. 1168-1177 ◽  
Author(s):  
Xiongfei Xu ◽  
Hai Yi ◽  
Zhenhong Guo ◽  
Cheng Qian ◽  
Sheng Xia ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Fas Ligand ◽  
Ifn Γ ◽  
Regulatory Dendritic Cells

scholarly journals Human Dendritic Cells Stimulated via TLR7 and/or TLR8 Induce the Sequential Production of Il-10, IFN-γ, and IL-17A by Naive CD4+ T Cells

2009 ◽  
Vol 182 (6) ◽  
pp. 3372-3379 ◽  
Author(s):  
Vincent Lombardi ◽  
Laurence Van Overtvelt ◽  
Stéphane Horiot ◽  
Philippe Moingeon
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Ifn Γ ◽  
Human Dendritic Cells

scholarly journals A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 ◽  
Vol 183 (4) ◽  
pp. 1789-1796 ◽  
Author(s):  
G Süss ◽  
K Shortman
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Fas Ligand ◽  
Activated T Cells ◽  
T Cell Apoptosis ◽  
Peripheral T Cells ◽  
Surface Staining ◽  
Induced Apoptosis ◽  
Antigen Presenting

Dendritic cells (DC), the most efficient antigen-presenting cells, are well equipped for activation of naive CD4+ T cells by their expression of high levels of major histocompatibility complex and costimulator molecules. We now demonstrate that some DC are equally well equipped for killing these same T cells. Murine splenic DC consist of both conventional CD8alpha- DC and a major population of CD8alpha+ DC. Whereas CD8- DC induce a vigorous proliferative response in CD4 T cells, CD8+ DC induce a lesser response that is associated with marked T cell apoptosis. By using various mixtures of T cells and DC from Fas-mutant lpr/lpr mice and Fas-ligand (FasL) mutant gld/gld mice, we show this death is due to interaction of Fas on activated T cells with FasL on CD8+ DC. Furthermore, we show by direct surface staining that CD8+ DC, but not CD8- DC, express FasL at high levels. These findings indicate that FasL+ CD8+ DC are a specialized subgroup of DC with a role in the regulation of the response of primary peripheral T cells.

scholarly journals IL-12hi Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ–Dependent Apoptosis of Alloreactive CD4+ T Cells In Vitro and Reduce Lethal Graft-Versus-Host Disease

2014 ◽  
Vol 20 (2) ◽  
pp. 192-201 ◽  
Author(s):  
Elizabeth O. Stenger ◽  
Brian R. Rosborough ◽  
Lisa R. Mathews ◽  
Huihui Ma ◽  
Markus Y. Mapara ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Graft Versus Host Disease ◽  
Cd4 T Cells ◽  
Host Disease ◽  
Graft Versus Host ◽  
Ifn Γ

scholarly journals Activation of purified allogeneic CD4+ T cells by rat bone marrow-derived dendritic cells induces concurrent secretion of IFN-γ, IL-4, and IL-10

2005 ◽  
Vol 101 (2) ◽  
pp. 193-201 ◽  
Author(s):  
Shorena Janelidze ◽  
Karin Enell ◽  
Edward Visse ◽  
Anna Darabi ◽  
Leif G. Salford ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Ifn Γ ◽  
Rat Bone

Wnt5a signaling increases IL-12 secretion by human dendritic cells and enhances IFN-γ production by CD4+ T cells

2014 ◽  
Vol 162 (1) ◽  
pp. 188-199 ◽  
Author(s):  
Jaris Valencia ◽  
Víctor G. Martínez ◽  
Laura Hidalgo ◽  
Carmen Hernández-López ◽  
Noelia M. Canseco ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Ifn Γ ◽  
Human Dendritic Cells

scholarly journals Atg5 but not Atg7 in dendritic cells enhances IL-2 and IFN-γ production by Toxoplasma gondii-reactive CD4+ T cells

2015 ◽  
Vol 17 (4) ◽  
pp. 275-284 ◽  
Author(s):  
Elizabeth Liu ◽  
Jennifer Van Grol ◽  
Carlos S. Subauste
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Toxoplasma Gondii ◽  
Cd4 T Cells ◽  
Ifn Γ

scholarly journals Epinephrine-primed murine bone marrow-derived dendritic cells facilitate production of IL-17A and IL-4 but not IFN-γ by CD4+ T cells

2010 ◽  
Vol 24 (7) ◽  
pp. 1126-1136 ◽  
Author(s):  
Byung-Jin Kim ◽  
Harlan P. Jones
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Murine Bone Marrow ◽  
Ifn Γ

Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent

1993 ◽  
Vol 5 (9) ◽  
pp. 1119-1128 ◽  
Author(s):  
Steven E. Macatonia ◽  
Chyi-Song Hsleh ◽  
Kenneth M. Murphy ◽  
Anne O'Garra
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Transgenic Mice ◽  
Cd4 T Cells ◽  
Ifn Γ

scholarly journals Depletion of Cd4+ T Cells Causes Reactivation of Murine Persistent Tuberculosis despite Continued Expression of Interferon γ and Nitric Oxide Synthase 2

2000 ◽  
Vol 192 (3) ◽  
pp. 347-358 ◽  
Author(s):  
Charles A. Scanga ◽  
V.P. Mohan ◽  
Keming Yu ◽  
Heather Joseph ◽  
Kathryn Tanaka ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
T Cells ◽  
T Cell ◽  
Persistent Infection ◽  
Cd4 T Cells ◽  
Macrophage Activation ◽  
Latent Tuberculosis ◽  
Cd4 T Cell ◽  
Ifn Γ ◽  
Oxide Synthase

Tuberculosis is a major cause of death in much of the world. Current estimates are that one-third of the world's population is infected with Mycobacterium tuberculosis. Most infected persons control the infection but in many cases may not eliminate the organism. Reactivation of this clinically latent infection is responsible for a large proportion of active tuberculosis cases. A major risk factor for reactivation of latent tuberculosis is HIV infection, suggesting a role for the CD4+ T cell subset in maintaining the latent persistent infection. In this study, we tested the requirement for CD4+ T cells in preventing reactivation in a murine model of latent tuberculosis. Antibody-mediated depletion of CD4+ T cells resulted in rapid reactivation of a persistent infection, with dramatically increased bacterial numbers in the organs, increased pathology in the lungs, and decreased survival. Although CD4+ T cells are believed to be a major source of interferon (IFN)-γ, expression of the gene for IFN-γ in the lungs of CD4+ T cell–depleted mice was similar to that in control mice. In addition, inducible nitric oxide synthase production and activity was unimpaired after CD4+ T cell depletion, indicating that macrophage activation was present even during CD4+ T cell deficiency. These data indicate that CD4+ T cells are necessary to prevent reactivation but may have roles in addition to IFN-γ production and macrophage activation in controlling a persistent tuberculous infection.

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