scholarly journals AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Bibianna Purgina ◽  
Uma N. M. Rao ◽  
Markku Miettinen ◽  
Liron Pantanowitz

The number of reported cases of smooth muscle tumor (SMT) arising in patients with AIDS has been increasing since the mid-1990s. The aim of this study is to characterize the epidemiology, clinical manifestations, pathologic features, prognosis and, management of Epstein-Barr virus-related SMT (EBV-SMT) in patients with AIDS. An English language literature search identified 53 articles including 64 reported cases of EBV-SMT. The majority of these reports involved patients who were young, severely immunosuppressed, and had multifocal tumors. The central nervous system was the most common site to be involved. Histologically, tumors had smooth muscle features and were immunoreactive for muscle markers and all but two tumors demonstrated the presence of EBV by either immunohistochemistry, in situ hybridization, and/or PCR. While mitoses and/or necrosis were used to separate leiomyoma from leiomyosarcoma, these features did not correlate with clinical outcome. Treatment included primarily resection, and less often radiotherapy, chemotherapy and highly active antiretroviral therapy (HAART). Overall, EBV-SMTs appear to have variable aggressiveness and clinical outcome and may exhibit a more favorable prognosis compared to conventional leiomyosarcoma. Tumor-related death from EBV-SMT occurred in only 4 of 51 patients.

2009 ◽  
Vol 133 (8) ◽  
pp. 1238-1241
Author(s):  
Le Yu ◽  
Anthony J. Aldave ◽  
Ben J. Glasgow

Abstract Epstein-Barr virus infection has been linked to the development of smooth muscle tumors in immunocompromised patients with organ transplants and acquired immunodeficiency syndrome. A 52-year-old female recipient of a renal transplant presented with enlarging masses of the left iris. Incisional biopsy of the mass revealed a smooth muscle tumor of the iris. Epstein-Barr virus infection was confirmed by in situ hybridization for Epstein-Barr virus–encoded, small RNA in tumor cells. Eight months after total iridectomy the patient was free of disease. Although the prognosis and classification of Epstein-Barr virus–associated smooth muscle tumors are controversial, mortalities caused by these tumors are rare.


2014 ◽  
Vol 109 ◽  
pp. S355
Author(s):  
Sricharitha Krishnamoorthy ◽  
Arup Maitra ◽  
Jennifer Bolyard ◽  
Zuoliang Xiao

2006 ◽  
Vol 8 (5) ◽  
pp. 1301-1307 ◽  
Author(s):  
Tsunekazu Hishima ◽  
Naoki Oyaizu ◽  
Takeshi Fujii ◽  
Natsuo Tachikawa ◽  
Atsushi Ajisawa ◽  
...  

1996 ◽  
Vol 46 (8) ◽  
pp. 601-604 ◽  
Author(s):  
Yoshito Sadahira ◽  
Takuya Moriya ◽  
Teruo Shirabe ◽  
Tsuyoshi Matsuno ◽  
Toshiaki Manabe

2004 ◽  
Vol 7 (2) ◽  
pp. 198-203 ◽  
Author(s):  
Shimareet Kumar ◽  
Mariarita Santi ◽  
Gilbert Vezina ◽  
Tena Rosser ◽  
Roma S. Chandra ◽  
...  

We describe the clinicopathologic features of an Epstein-Barr virus (EBV)-associated smooth muscle tumor arising in the basal ganglia of a 10-year-old human immunodeficiency virus (HIV)-positive child. Only a few cases of intracranial smooth muscle tumors are reported in the literature and virtually all of these have been extra-axial, involving the dura or sinuses in HIV+ adults. Our case underscores the need to include an EBV-associated smooth muscle tumor in the differential diagnosis when evaluating intracranial mass lesions in immunodeficient children.


1996 ◽  
Vol 20 (11) ◽  
pp. 1418-1425 ◽  
Author(s):  
Brigitte Le Bail ◽  
Delphine Morel ◽  
Patrick Mérel ◽  
François Comeau ◽  
Jean-Philippe Merlio ◽  
...  

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