Somatosympathetic Reflex and Acupuncture-Related Analgesia

2009 ◽  
Vol 52 (5 (Supplement)) ◽  
pp. 345-357 ◽  
Author(s):  
Chung-Shin Huang ◽  
Yuan-Feen Tsai
Keyword(s):  
Somatosympathetic Reflex

scholarly journals Rostral ventral medulla 5-HT1A receptors selectively inhibit the somatosympathetic reflex

2001 ◽  
Vol 280 (5) ◽  
pp. R1261-R1268 ◽  
Author(s):  
Takashi Miyawaki ◽  
Ann K. Goodchild ◽  
Paul M. Pilowsky
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Sympathetic Nerve Activity ◽  
Selective Inhibition ◽  
Inhibitory Effect ◽  
Ventrolateral Medulla ◽  
Arterial Blood ◽  
Potent Inhibition ◽  
Somatosympathetic Reflex

The role of the 5-hydroxytryptamine (5-HT1A) receptors in the rostral ventrolateral medulla (RVLM) on somatosympathetic, baroreceptor, and chemoreceptor reflexes was examined in anesthetized rats. Microinjection of the selective 5-HT1A agonist 8-hydroxy-di- n-propylamino tetralin (8-OH-DPAT) decreased arterial blood pressure and splanchnic sympathetic nerve activity (SNA). Electrical stimulation of the hindlimb evoked early and late excitatory sympathetic responses. Bilateral microinjection in the RVLM of 8-OH-DPAT markedly attenuated both the early and late responses. This potent inhibition of the somatosympathetic reflex persisted even after SNA and arterial blood pressure returned to preinjection levels. Preinjection of the selective 5-HT1A antagonist NAN-190 in the RVLM blocked the sympathoinhibitory effect of 8-OH-DPAT and attenuated the inhibitory effect on the somatosympathetic reflex. 8-OH-DPAT injected in the RVLM did not affect baroreceptor or chemoreceptor reflexes. Our findings suggest that activation of 5-HT1A receptors in the RVLM exerts a potent, selective inhibition on the somatosympathetic reflex.

Interaction of descending spinal sympathetic pathways and afferent nerves

1978 ◽  
Vol 234 (3) ◽  
pp. H223-H229
Author(s):  
S. M. Barman ◽  
R. D. Wurster
Keyword(s):  
Nerve Fibers ◽  
Nerve Activity ◽  
Afferent Nerves ◽  
Afferent Nerve Fibers ◽  
Somatosympathetic Reflex ◽  
Reflex Activation ◽  
Dorsolateral Funiculus ◽  
Ventrolateral Funiculus ◽  
Stimulation Of ◽  
Excitatory Pathway

With the use of computer-aided techniques, the interaction of descending spinal sympathetic pathways and afferent nerve fibers (cervical dorsal roots and tibial nerve) in regulation of thoracic (T2) preganglionic nerve activity was investigated in anesthetized, vagotomized, and paralyzed cats. High-frequency activation of a sympathoinhibitory pathway (ventrolateral funiculus) depressed the evoked discharges in the T2 preganglionic nerve elicited by stimulation of a sympathoexcitatory pathway (dorsolateral funiculus) and the spinal component of the somatosympathetic reflex. Submaximal evoked responses were also inhibited through baroreceptor reflex activation (blood pressure elevations up to 225 mmHg). Facilitation of the spinal component of the somatosympathetic reflex occurred during stimulation of the excitatory pathway. Carotid occlusion (baroreceptor inactivation) facilitated the submaximal evoked discharges from stimulation of the descending excitatory pathway. These data support the contention that sympathetic nerve activity can be modified by the integration of excitatory and inhibitory impulses at the spinal level.

The effects of morphine administered intrathecally on the somatosympathetic reflex discharges in anesthetized cats

1986 ◽  
Vol 71 (3) ◽  
pp. 345-350 ◽  
Author(s):  
Akio Sato ◽  
Yuko Sato ◽  
Atsuko Suzuki ◽  
Rand S. Swenson
Keyword(s):  
Somatosympathetic Reflex

Dexmedetomidine Attenuates the Somatosympathetic Reflex Via Spinal Mechanisms

1994 ◽  
Vol 81 (SUPPLEMENT) ◽  
pp. A939 ◽  
Author(s):  
E. Samso ◽  
N. E. Farber ◽  
D. Schwabe ◽  
J. P. Kampine ◽  
W. T. Schmeling
Keyword(s):  
Somatosympathetic Reflex

scholarly journals The somato-sympathetic reflex in the spontaneous hypertensive rats

2003 ◽  
Vol 9 (3) ◽  
pp. 102-106
Author(s):  
Yu. I. Shcherbin ◽  
R. S. Khrustaleva ◽  
V. A. Cirlin
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Silent Period ◽  
Hypertensive Rats ◽  
Electrical Shock ◽  
Spontaneously Hypertensive ◽  
Shock Amplitude ◽  
Somatosympathetic Reflex ◽  
Cervical Sympathetic ◽  
Myelinated Fibres ◽  
Stimulation Of

In chloralose anesthetized and paralyzed spontaneously hypertensive rats (SHR) a somatosympathetic reflex in the cervical sympathetic trunk elicited by a single electrical shock to forelimb afferent fibres in the median nerve was recorded. It has been shown that the somatosympathetic reflex consists of two responses and following silent period. The А-response evoked by the somatic myelinated afferent fibres stimulation, and C-respon.se elicited by the both stimulation of myelinated and unmyelinated afferent fibres. The silent period occurred with the myelinated fibres stimulation. Its duration was proportional to the electrical shock amplitude. The А-response consisted of four waves, the three of them formed early and late responses.

scholarly journals Spinal GABAA receptors do not mediate the sympathetic baroreceptor reflex in the rat

2000 ◽  
Vol 279 (1) ◽  
pp. R320-R331 ◽  
Author(s):  
Ann K. Goodchild ◽  
Bart T. M. Van Deurzen ◽  
Qi-Jian Sun ◽  
John Chalmers ◽  
Paul M. Pilowsky
Keyword(s):  
Intrathecal Injection ◽  
Baroreceptor Reflex ◽  
Glycine Receptors ◽  
Measured Variable ◽  
Depressor Response ◽  
Aortic Depressor Nerve ◽  
Somatosympathetic Reflex ◽  
Dose Dependent Increase ◽  
Dose Dependent ◽  
Nerve Discharge

Activation of baroreceptors causes efferent sympathetic nerve activity (SNA) to fall. Two mechanisms could account for this sympathoinhibition: disfacilitation of sympathetic preganglionic neurons (SPN) and/or direct inhibition of SPN. The roles that spinal GABA and glycine receptors play in the baroreceptor reflex were examined in anesthetized, paralyzed, and artificially ventilated rats. Spinal GABAA receptors were blocked by an intrathecal injection of bicuculline methiodide, whereas glycine receptors were blocked with strychnine. Baroreceptors were activated by stimulation of the aortic depressor nerve (ADN), and a somatosympathetic reflex was used as control. After an intrathecal injection of vehicle, there was no effect on any measured variable or evoked reflex. In contrast, bicuculline caused a dose-dependent increase in arterial pressure, SNA, phrenic nerve discharge, and it significantly facilitated the somatosympathetic reflex. However, bicuculline did not attenuate either the depressor response or sympathoinhibition evoked after ADN stimulation. Similarly, strychnine did not affect the baroreceptor-induced depressor response. Thus GABAA and glycine receptors in the spinal cord have no significant role in baroreceptor-mediated sympathoinhibition.

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