scholarly journals A prospective, randomized, double blind study to compare the effects of equiosmolar solutions of 3% hypertonic saline and 20% mannitol on reduction of brain-bulk during elective craniotomy for supratentorial brain tumor resection

2014 ◽  
Vol 8 (3) ◽  
pp. 388 ◽  
Author(s):  
KhalidP Sofi ◽  
AbrarA Wani ◽  
ZafferA Malik ◽  
ShafatA Mir ◽  
ImtiyazA Naqash
Keyword(s):  
Brain Tumor ◽  
Hypertonic Saline ◽  
Tumor Resection ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Brain Tumor Resection

Hypertonic saline dextran produces early (8-12 hrs) fluid sparing in burn resuscitation: A 24-hr prospective, double-blind study in sheep

2000 ◽  
Vol 28 (1) ◽  
pp. 163-171 ◽  
Author(s):  
Geir Ivar Elgjo ◽  
Luiz F. Poli de Figueiredo ◽  
Paul J. Schenarts ◽  
Daniel L. Traber ◽  
Lillian D. Traber ◽  
...  
Keyword(s):  
Hypertonic Saline ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Burn Resuscitation

Effect of Corticosteroids on Facial Function after Cerebellopontine Angle Tumor Removal: A Double-Blind Study versus Placebo

2015 ◽  
Vol 20 (4) ◽  
pp. 213-221 ◽  
Author(s):  
Alexis Bozorg Grayeli ◽  
Evelyne Ferrary ◽  
Florence Tubach ◽  
Isabelle Bernat ◽  
Olivier Deguine ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Facial Palsy ◽  
Cerebellopontine Angle ◽  
Tumor Resection ◽  
Blind Study ◽  
Double Blind Study ◽  
Tumor Removal ◽  
Double Blind ◽  
To Receive ◽  
Facial Function

The aim of this study was to assess the effect of corticosteroids administered intra- and postoperatively on the occurrence of facial palsy after a cerebellopontine angle (CPA) tumor resection, and to investigate pre- and intraoperative prognostic factors. A multicenter, prospective, randomized, double-blind and versus-placebo study was conducted between 2006 and 2010. Three hundred and ten patients operated on for a CPA tumor (96% vestibular schwannomas, 4% miscellaneous) were included by five participating centers. The population was stratified into patients with small (≤15 mm CPA on axial MRI views) and large tumors. In each group, patients were randomized to receive corticosteroid (1 mg/kg/day i.v. methylprednisolone intraoperatively and at postoperative days 1-5) or placebo. Steroids did not affect the facial function at postoperative days 1, 8 and 30 in patients with small or large tumors as evaluated by House and Brackmann grading.

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